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Neurotransmitters in the Mammalian Striatum: Neuronal Circuits and Heterogeneity

Published online by Cambridge University Press:  05 January 2016

K. Semba ,
H.C. Fibiger  and
S.R. Vincent
K. Semba*
Affiliation:
Division of Neurological Sciences, Department of Psychiatry, University of British Columbia, Vancouver
H.C. Fibiger
Affiliation:
Division of Neurological Sciences, Department of Psychiatry, University of British Columbia, Vancouver
S.R. Vincent
Affiliation:
Division of Neurological Sciences, Department of Psychiatry, University of British Columbia, Vancouver
*
Department of Neurological Sciences, Department of Psychiatry, The University of British Columbia, 2136 West Mall, Vancouver, B.C., Canada V6T 2A1
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Abstract:

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The major input and output pathways of the mammalian striatum have been well established. Recent studies have identified a number of neurotransmitters used by these pathways as well as by striatal interneurons, and have begun to unravel their synaptic connections. The major output neurons have been identified as medium spiny neurons which contain ɣ-aminobutyric acid (GABA), endogeneous opioids, and substance P. These neurons project to the pallidum and substantia nigra in a topographic and probably chemically organized manner. The major striatal afferents from the cerebral cortex, thalamus, and substantia nigra terminate, at least in part, on these striatal projection neurons. Striatal interneurons contain acetylcholine, GABA, and somatostatin plus neuropeptide Y, and appear to synapse on striatal projection neurons. In recent years, much activity has been directed to the neurochemical and hodological heterogeneities which occur at a macroscopic level in the striatum. This has led to the concept of a patch-matrix organization in the striatum.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 14 , Issue S3 , August 1987 , pp. 386 - 394
Copyright
Copyright © Canadian Neurological Sciences Federation 1987

References

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