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Ouabain Induced Stereotyped Behavior in Rats

Published online by Cambridge University Press:  18 September 2015

D.L.W. Davidson ,
R.F. Butterworth ,
F. Bélanger  and
A. Barbeau
R.F. Butterworth
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
F. Bélanger*
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
A. Barbeau
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
*
Clinical Research Institute of Montreal, 110 Pine Ave. West, Montreal, H2W 1R7, Canada.
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Stereotyped behavior was inclined in rats with ouabain administered intraventricularly in doses of 2, 3 and 4 μg in 50 μl saline. Haloperiodol reduced the stereotyped behaviour. Monoamine turnover studies showed a reduction in concentration of norepinephrine in hippocampus and midbrain, an increase in norepinephrine turnover in the medulla oblongata and a reduction in dopamine turnover in the striatum. The interpretation of these finds is discussed. It is suggested that this model could be significant clinically as it demonstrates that impairment of Na+-K+-ATP'ase may result in behavioral abnormalities characterised by stereotypy.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 4 , November 1978 , pp. 401 - 404
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

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