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P.027 Sex differences in symptomatic intracranial hemorrhage and procedural complications after endovascular thrombectomy: Analysis of the OPTIMISE registry

Published online by Cambridge University Press:  10 July 2025

AO Diallo
Affiliation:
(Montreal)*
JA Rivillas
Affiliation:
(Montreal)*
AY Poppe
Affiliation:
(Montreal)
O Bereznyakova
Affiliation:
(Montreal)
RH Swartz
Affiliation:
(Toronto)
G Stotts
Affiliation:
(Ottawa)
J Shankar
Affiliation:
(Winnipeg)
N Singh
Affiliation:
(Winnipeg)
J Mandzia
Affiliation:
(London)
AH Katsanos
Affiliation:
(Hamilton)
L Zhou
Affiliation:
(Vancouver)
MK Heran
Affiliation:
(Vancouver)
S Verreault
Affiliation:
(Québec City)
G Jacquin
Affiliation:
(Montreal)
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Abstract

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Background: Studies have found similar rates of functional independence for men and women after endovascular thrombectomy (EVT). Less is known regarding EVT-related procedural complications and symptomatic intracerebral hemorrhage (sICH) between sexes. Methods: Using the OPTIMISE registry including data from 20 comprehensive stroke centers across Canada between 1/1/2018 and 12/31/2022, we performed a retrospective descriptive analysis of patients divided between men and women. Hemorrhagic transformation on follow-up imaging with associated clinical deterioration was required to define sICH. Results: 3631 patients were included (1778 men and 1853 women) for analysis. Female patients were older (71.8±14.6 vs 68.0±13.1 years, p<0.001). There were no differences in sICH rates (2.5% men vs. 2% women, p= 0.388}. Procedural complication rates were not different between men and women (5.8 vs 5.6% p=0.76): dissection {26 (1.5%) vs. 30 (1.6%), p=0.804}, perforation {11 (0.6%) vs. 7 (0.4%), p=0.426}, embolization {25 (1.4%) vs. 25 (1.3%), p=0.996} and arterial access complications {45 (2.5%) vs. 43 (2.3%), p=0.761}. Conclusions: In this large multicentre registry of stroke patients undergoing EVT, men and women had similarly low and reassuring rates of sICH and procedural complications. This complements previous data showing similar functional outcomes for men and women after EVT.

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Abstracts
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of Canadian Neurological Sciences Federation