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Pharmacokinetic Aspects of Anxiolytic Drug Therapy

Published online by Cambridge University Press:  18 September 2015

David J. Greenblatt  and
Richard I. Shader
David J. Greenblatt*
Affiliation:
Division of Clinical Pharmacology, Departments of Psychiatry and Medicine, Tufts University School of Medicine and New England Medical Center Hospital
Richard I. Shader
Affiliation:
Division of Clinical Pharmacology, Departments of Psychiatry and Medicine, Tufts University School of Medicine and New England Medical Center Hospital
*
Division of Clinical Pharmacology, Box 1007, New England Medical Center Hospital, 171 Harrison Avenue, Boston, MA 02111
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Summary:

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Benzodiazepine derivatives are neuropharmacologically similar but may appear clinically distinct due to pharmacokinetic differences. The clinical effects of single doses depend mainly on rates of drug absorption and distribution, whereas drug accumulation is a major determinant of clinical action during multiple dosage. This paper outlines potential clinical implications of benzodiazepine pharmacokinetics.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 3 , August 1980 , pp. 269 - 270
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

REFERENCES

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