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Protein Kinase C and Growth Regulation of Malignant Gliomas

  • Gordon H. Baltuch (a1), Nora P. Dooley (a1), Jean-Guy Villemure (a1) and Voon Wee Yong (a1)

Abstract

This article reviews the role of the signal transduction enzyme protein kinase C in the regulation of growth of malignant gliomas, and describes how targetting this enzyme clinically can provide a novel approach to glioma therapy.

Résumé

Nous revoyons le rôle de l’enzyme de transduction du signal, la protéine kinase C, dans la régulation de la croissance des gliomes malins et nous décrivons comment le ciblage de cet enzyme peut fournir une approche nouvelle dans le traitement du gliome.

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Corresponding author

Montreal Neurological Institute, 3801 University Street, Montreal, Quebec, Canada H3A 2B4

References

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1. Berens, ME, Rutka, JT, Rosenblum, ML. Brain tumour epidemiology, growth, and invasion. Neurosurg Clin Am 1990; 1: 118.
2. Zülch, KJ. Histological Typing of Tumors of the Central Nervous System. Geneva, World Health Organization, 1979.
3. Cavenee, WK, White, RL. The genetic basis of cancer. Sci Am March 1995; 7279.
4. Bello, MJ, de Campos, JM, Kusak, ME, et al. Ascertainment of chromosome 7 gains in malignant gliomas by cytogenetic and RFLP Analyses. Cancer Genet Cytogenet 1994; 72: 5558.
5. Bello, MJ, de Campos, JM, Vaquero, J, et al. Molecular and cytogenetic analysis of chromosome 9 deletions in 75 malignant gliomas. Genes Chromosomes Cancer 1994; 9: 3341.
6. Collins, VP, James, CD. Genes and chromosomal alterations associated with the development of human gliomas. FASEB J 1993; 7: 926930.
7. Cavenee, WK, Scrable, HJ, James, CD. Molecular genetics of human cancer predisposition and progression. Mutat Res 1991; 247: 199202.
8. Louis, DN. The p53 gene and protein in human brain tumors. J Neuropathol Exp Neurol 1994; 53: 1121.
9. Gillaspy, GE, Mapstone, TB, Samols, D, Goldthwait, DA. Transcriptional patterns of growth factors and proto-oncogenes in human glioblastomas and normal glial cells. Cancer Lett 1992; 65:5560.
10. Arita, N, Hayakawa, T, Izumoto, S, et al. Epidermal growth factor receptors in human glioma. J Neurosurg 1989, 70: 916919.
11. Fleming, TP, Saxena, A, Clark, WC, et al. Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res 1992; 52:45504553.
12. Gammeltoft, S, Ballotti, R, Kowalski, A, Westermark, B, Obberghen, EV. Expression of two types of receptor for insulin-like growth factors in human malignant glioma. Cancer Res 1988; 48: 12331237.
13. Morrison, RS, Giordano, S, Yamaguchi, , et al. Basic fibroblast growth factor expression is required for clonogenic growth of human glioma cells. J Neurosci Res 1993; 34: 502509.
14. Batra, SK, Rasheed, BK, Bigner, SH, Bigner, DD. Biology of disease: oncogenes and anti-oncogenes in human central nervous system tumors. Lab Invest 1994; 71: 621637.
15. Von Deimling, A, Eibl, RH, Ohgaki, H, et al. p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma. Cancer Res 1992; 52: 29872990.
16. Fults, D, Brockmeyer, D, Tullous, MW, Pedone, CA, Cawthon, RM. p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression. Cancer Res 1992; 52: 674679.
17. Sidransky, D, Mikkelsen, T, Schechleimer, K, et al. Clonal expression of p53 mutant cells is associated with brain tumour progression. Nature 1992; 355: 846847.
18. El-Azouzi, M, Chung, RY, Farmer, GE, et al. Loss of distinct regions on the short arm of chromosome 17 associated with tumorigenesis of human astrocytomas. Proc Nat Acad Sci USA 1989; 86: 71867190.
19. Lang, FF, Miller, DC, Koslow, M, Newcomb, EW. Pathways leading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors. J Neurosurg 1994; 81:427436.
20. Cantley, LC, Auger, KR, Carpenter, C, et al. Oncogenes and signal transduction. Cell 1991; 64: 281302.
21. Berra, E, Diaz-Meco, MT, Dominguez, I, et al. Protein kinase C ς isoform is critical for mitogenic signal transduction. Cell 1993; 74: 555565.
22. Kolch, W, Heldecker, G, Kochs, G, et al. Protein kinase Ca activates RAF-1 by direct phosphorylation. Nature 1993; 364: 249252.
23. Nishizuka, Y. Intracellular signalling by hydrolysis of phospholipids and activation of protein kinase C. Science 1992; 258: 607613.
24. Hug, H, Sarre, TF. Protein kinase C isoenzymes: divergence in signal transduction? Biochem J 1993; 291: 329343.
25. Dekker, LV, Parker, PJ. Protein kinase C-a question of specificity. Trends Biol Sci 1994; 19: 7377.
26. Selbie, LA, Scmitz-Peiffer, C, Sheng, Y, et al. Molecular cloning and characterization of PKC, an atypical isoform of protein kinase C derived from insulin secreting cells. J Biol Chem 268: 2429624302.
27. Johannes, FJ, Prestle, J, Eis, S, et al. PKCμ is a novel, atypical member of the protein kinase C family. J Biol Chem 1994; 269: 61406148.
28. Mochly-Rosen, D, Khaner, H, Lopez, J. Identification of intracellular receptor proteins for activated protein kinase C. Proc Nat Acad Sci USA 1991; 88:39974000.
29. Berridge, MJ, Irvine, RF. Inositol phosphate, a novel second messenger in cellular signal transduction. Nature 1984; 312: 315321.
30. Hannun, YA, Bell, RM. Aminoacridines, potent inhibitors of protein kinase C. J Biol Chem 1988; 263:51245131.
31. Basu, A. The potential of protein kinase C as a target for anticancer treatment. Pharmacol Ther 1993; 59: 257280.
32. Wetsel, WC, Khan, WA, Merchethaler, I, et al. Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. J Cell Biol 1992; 117: 121133.
33. Fletcher, DJ, Ways, DK. Age-dependent expression of protein kinase C isoforms in rat islets. Diabetes 1991; 40: 14961503.
34. Osborne, NN, Wood, J, Groome, N. The occurrence of three calciumindependent protein kinase C subspecies (δ, ε and ς) in the retina of different species. Brain Res 1994; 637: 156160.
35. Castagna, M, Takai, Y, Kaibuchi, K, et al. Direct activation of calciumactivated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem 1982; 257: 78477851.
36. Fleischman, LF, Chahwala, SB, Cantley, L. Ras-transformed cells: altered levels of phosphotidylinositol-4,5-biphosphate and catabolites. Science 1986; 231: 407410.
37. O’Brian, CA, Liskamp, RM, Solomon, DH, Weinstein, IB. Inhibition of protein kinase C by tamoxifen. Cancer Res 1985; 45: 24622465.
38. Alvaro, V, Touraine, P, Vozari, RR, et al. Protein kinase C activity and expression in normal and adenomatous human pituitaries. Int J Cane 1992; 50:724730.
39. Weinstein, IB. The role of protein kinase C in growth control and the concept of carcinogenesis as a progressive disorder in signal transduction. Adv Second Mess and Phosphoprot Res 1990; 24: 307316.
40. Gopalakrishna, R, Barsky, SH. Tumor promotor-induced membranebound protein kinase C regulates hematogenous metastasis. Proc Natl Acad Sci 1988; 85:612616.
41. Schwartz, GK, Redwood, SM, Ohnuma, T, et al. Inhibition of invasive human bladder carcinoma cells by protein kinase C inhibitor staurosporine. J Natl Cancer Inst 1990; 82: 17531756.
42. Blobe, GC, Sachs, CW, Khan, WA, et al. Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrugresistant MCF-7 cells. J Biol Chem 1993; 268: 658664.
43. Huang, M, Chida, K, Kamata, N, et al. Enhancement of inositol phospholipid metabolism and activation of protein kinase C in ras-transformed rat fibroblasts. J Biol Chem 1988; 263: 1797517980.
44. Borner, C. Guadagno, SN, Fabbro, D, Weinstein, IB. Expression of four protein kinase C isoforms in rat fibroblasts. J Biol Chem 1992; 267:1289212899.
45. Delage, S, Chastre, E, Empereur, S, et al. Increased protein kinase C Ó expression in human colonic caco-2 cells after insertion of human Ha-ras or polyoma virus middle T oncogenes. Cancer Res 1993; 53:27622770.
46. Eldar, H, Zisman, Y, Ullrich, A, Livneh, E. Overexpression of protein kinase Cα-subtype in swiss/3T3 fibroblasts causes loss of both high and low affinity receptor numbers for epidermal growth factor. J Biol Chem 1990, 265: 1329013296.
47. Gruber, JR, Ohno, S, Niles, RM. Increased expression of protein kinase Ca plays a key role in retinoic acid-induced melanoma differentiation. J Biol Chem 1992; 267: 1335613360.
48. Housey, GM, Johnson, MD, Hsiao, WLW, et al. Overproduction of protein kinase C causes disordered growth control in rat fibroblasts. Cell 1988; 52: 343354.
49. Choi, PM, Tchou-Wong K-M, Weinstein, B. Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression. Mol Cell Biol 1990; 10: 46504657.
50. Yamanishi, DT, Graham, M, Buckmeier, JA, Meykens, FL. The differential expression of protein kinase C genes in normal human neonatal melanocytes and metastatic melanomas. Carcinogenesis 1991; 12: 105109.
51. Cacace, AM, Guadagno, SN, Krauss, RS, Fabbro, D, Weinstein, IB. The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts. Oncogene 1993; 8: 20952104.
52. Mischak, H, Goodnight, J, Kolch, W, et al. Overexpression of protein kinase C-δ and ε in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J Biol Chem 1993; 268: 60906096.
53. Tanaka, C, Nishizuka, Y. The protein kinase C family for neuronal signalling. Ann Rev Neurosci 1994; 17: 551567.
54. Ben-Ari, Y, Anikszteijn, L, Bregestovski, P. Protein kinase C modulation of NMDA currents: an important link for LTP induction. Trends Neurosci 1992; 15: 333339.
55. Roivainen, R, McMahon, T, Messing, RO. Protein kinase C isozymes that mediate enhancement of neurite outgrowth by ethanol and phorbol esters in PC 12 cells. Brain Res 1993; 624: 8593.
56. O’Driscoll, KR, Teng, KK, Fabbro, D, Greene, LA, Weinstein, IB. Selective translocation of protein kinase C-8 in PC 12 cells during nerve growth factor-induced neuritogenesis. Mol Biol Cell 1995; 6: 449458.
57. Yong, VW, Sekiguichi, S, Kim, MW, Kim, SU. Phorbol esters enhances morphological differentiation of oligodendrocytes in culture. J Neurosci Res 1988; 19: 187194.
58. Yong, VW, Dooley, NP, Noble, PG. Protein kinase C in cultured adult human oligodendrocytes: a potential role for isoform a as a mediator of process outgrowth. J Neurosci Res 1994; 39: 8396.
59. Honegger, P. Protein kinase C-activating tumour promotors enhance the differentiation of astrocytes in aggregating fetal brain cell cultures. J Neurochem 1986; 46: 15611566.
60. Shafit-Zagardo, B, Kume-Iwaki, A, Goldman, JE. Astrocytes regulate GFAP mRNA levels by cyclic AMP and protein kinase C-dependent mechanisms. Glia 1988; 1: 346354.
61. Mobley, PL, Scott, SL, Cruz, EG. Protein kinase C in astrocytes: a determinant of cell morphology. Brain Res 1986; 398: 366369.
62. Harrison, BC, Mobley, PL. Phorbol ester-induced change in astrocyte morphology: correlation with protein kinase C activation and protein phosphorylation. J Neurosci Res 1990; 25: 7180.
63. Murphy, S, McCabe, N, Morrow, C, Pearce, B. Phorbol ester stimulates proliferation of astrocytes in primary culture. Dev Brain Res 1987; 31: 133135.
64. Bhat, NR. Role of protein kinase C in glial cell proliferation. J Neurosci Res 1989; 22: 2027.
65. Sawada, M, Suzumura, A, Ohno, K, Marunouchi, T. Regulation of astrocyte proliferation by prostaglandin E2 and the a subtype of protein kinase C. Brain Res 1993; 613: 6773.
66. Yong, VW, Moumdjian, R, Yong, FP, et al. Gamma-interferon promotes proliferation of adult human astrocytes in vitro and reactive gliosis in the adult mouse brain in vivo. Proc Natl Acad Sci USA 1991; 88:70167020.
67. Yong, VW. Proliferation of human and mouse astrocytes in vitro: signalling through the protein kinase C pathway. J Neurol Sci 1992; 111:92103.
68. Couldwell, WT, Uhm, JH, Antel, JP, Yong, VW. Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro. Neurosurg 1991; 29: 880887.
69. Baltuch, GH, Dooley, NP, Couldwell, WT, Yong, VW. Staurosporine differentially inhibits glioma versus non-glioma cell lines. J NeuroOnc 1993; 16: 141147.
70. Couldwell, WT, Antel, JP, Yong, VW. Protein kinase C activity correlates with the growth rate of malignant gliomas. II Effects of glioma mitogens and modulators of PKC. Neurosurg 1992; 31: 717724.
71. Pollack, IF, Randall, MS, Kristofik, MP, et al. Effects of tamoxifen on DNA synthesis and proliferation of human glioma lines in vitro. Cancer Res 1990; 50: 71347138.
72. Baltuch, GH, Dooley, NP, Rostworowski, KM, Villemure, J-G, Yong, VW. Protein kinase C isoform a overexpression in C6 glioma and its role in cell proliferation. J NeuroOnc (in press).
73. Dooley, NP, Baltuch, GB, Paton, A, et al. Phosphorothioate antisense oligonucleotides to protein kinase Ca inhibit human glioma growth in vitro, submitted.
74. Reifenberger, G, Deckert, M, Wechsler, W. Immunohistochemical determination of protein kinase C expression and proliferative activity in human brain tumors. Acta Neuropathol 1989; 78: 166175.
75. Todo, T, Shitara, N, Nakamura, H, Takakura, K, Ikeda, K. Immunohistochemical demonstration of protein kinase C isozymes in human brain tumours. Neurosurgery 1991; 108: 1116.
76. Benzil, DL, Finkelstein, SD, Epstein, MH, Finch, PW. Expression pattern of a-protein kinase C in human astrocytomas indicates a role in malignant progression. Cancer Res 1992; 52: 29512956.
77. Raizada, MK, Morse, CA, Gonzales, RA, Crews, FT, Sumners, C. Receptors for phorbol esters are primarily localized in neurons: comparison of neuronal and glial cultures. Neurochem Res 1988; 13:5156.
78. Saito, N, Kikkawa, U, Nishizuka, Y, Tanaka, C. Distribution of protein kinase C-like immunoreactive neurons in rat brain. J Neurosci 1988; 8:369382.
79. Clark, EA, Leach, KS, Trojanowski, JQ, Lee, VM-Y. Characterization and differential distribution of the three major human protein kinase C isozymes (PKCa, PKCp\ and PKCy) of the central nervous system in normal and Alzheimer’s disease brains. Lab Invest 1991; 64:3544.
80. Shimosawa, S, Hachiya, T, Hagiwara, M, et al. Type-specific expression of protein kinase C isozymes in human brain tumours. Neurosci Lett 1990; 108: 1116.
81. Misra-Press, A, Fields, AP, Samols, D, Goldthwait, DA. Protein kinase C isoforms in human glioblastoma cells. Glia 1992; 6: 188197.
82. Xiao, H, Goldthwait, DA, Mapstone, T. The identification of four protein kinase C isoforms in human glioblastoma cell lines: PKC alpha, gamma, epsilon, and zeta. J Neurosurg 1994; 81: 734740.
83. Ahmad, S, Mineta, T, Martuza, RL, Glazer, RI. Antisense expression of protein kinase Cot inhibits the growth and tumourigenicity of human glioblastoma cells. Neurosurgery 1994; 35: 904909.
84. Matsumoto, T, Tani, E, Yamaura, , et al. Effects of protein kinase C modulators on multidrug resistance in human glioma cells. Neurosurgery 1995; 36: 565572.
85. Yong, VW, Antel, JP. Culture of glial cells from human brain biopsies. In: Federoff, S, Richardson, A, eds. Protocols for neural cell culture. St Louis: Humana Press, 1992: 8196.
86. McConkey, DJ, Hartzell, P, Jondal, M, Orrenius, S. Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C. J Biol Chem 1989; 264: 1339913402.
87. Jarvis, WD, Turner, AJ, Povirk, LF, Traylor, RS, Grant, S. Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocyte leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res 1992; 54: 17071714.
88. Haimovitz-Friedman, A, Balaban, N, McLoughlin, M. et al. Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis. Cancer Res 1994; 54:25912597.
89. Couldwell, WT, Hinton, DR, He, S, et al. Protein kinase inhibitors induce apoptosis in human malignant glioma lines. FEBS Lett 1994; 345:4346.
90. Weller, M, Frei, K, Groscurth, P. et al. Anti-Fas/APO-1 antibodymediated apoptosis of cultured human glioma cells. J Clin Invest 1994; 94:954964.
91. Uhm, JH, Dooley, NP, Villemure, J-G, Yong, VW. Glioma invasion requires a 72 kDa metalloprotease that is regulated by protein kinase C, submitted.
92. Chambers, TC, Pohl, J, Raynor, RL, et al. Identification of specific sites in human P-glycoprotein phosphorylated by protein kinase C. J Biol Chem 1993: 268: 45924595.
93. Zhang, W, Yamada, H, Sakai, N, Niikawa, S, Nozawa, Y. Enhancement of radiosensitivity by tamoxifen in C6 glioma cells. Neurosurgery 1992; 31:125730.
94. Vertosick, FT, Selker, RG, Pollack, IF, et al. The treatment of intracranial malignant gliomas using orally administered tamoxifen therapy: preliminary results in a series of “failed” patients. Neurosurgery 1992: 30: 897903.
95. Baltuch, GH, Couldwell, WT, Villemure, J-G. Yong, VW. Protein kinase C inhibitors suppress cell growth in established and low passage cell lines. A comparison between staurosporine and tamoxifen. Neurosurgery 1993; 33: 495501.
96. Baltuch, GH, Shenouda, G, Langleben, A, Villemure, J-G. High dose tamoxifen in the treatment of recurrent high grade glioma: a report of clinical stabilization and tumour regression. Can J Neurol Sci 1993; 20: 168170.
97. Couldwell, WT, Weiss, MH, DeGiorgio, CM, et al. Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen. Neurosurgery 1993: 32: 485490.
98. Yong, VW, Tejada-Berges, T, Goodyer, CG, Antel, JP, Yong, FP. Differential proliferative response of human and mouse astrocytes to gamma-interferon. Glia 1992; 6: 269280.

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