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Rapid Reversal of Ergotamine-induced Vasospasm

Published online by Cambridge University Press:  18 September 2015

P. Jeffrey Lewis ,
Thomas W. Noseworthy ,
Avril A. Fitzgerald ,
George C. Andrews  and
Albert J. Geeraert
P. Jeffrey Lewis
Affiliation:
Departments of Adult Intensive Care, Medicine, Diagnostic Imaging and Surgery, Royal Alexandra Hospital and the Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
Thomas W. Noseworthy*
Affiliation:
Departments of Adult Intensive Care, Medicine, Diagnostic Imaging and Surgery, Royal Alexandra Hospital and the Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
Avril A. Fitzgerald
Affiliation:
Departments of Adult Intensive Care, Medicine, Diagnostic Imaging and Surgery, Royal Alexandra Hospital and the Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
George C. Andrews
Affiliation:
Departments of Adult Intensive Care, Medicine, Diagnostic Imaging and Surgery, Royal Alexandra Hospital and the Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
Albert J. Geeraert
Affiliation:
Departments of Adult Intensive Care, Medicine, Diagnostic Imaging and Surgery, Royal Alexandra Hospital and the Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
*
Royal Alexandra Hospital, 10240 Kingsway Avenue, Room 4228, Edmonton, Alberta, Canada T5H 3V9
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Abstract:

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Peripheral ischemia, secondary to ergotamine tartrate and caffeine suppositories is reported in a 48-year-old female. Lower extremity pre-gangrenous changes were unresponsive to surgical sympathectomy, calcium channel blockade, intra-arterial vasodilators and systemic anticoagulation. A dramatic clinical and radiological reversal of the vasospasm was obtained with intravenous sodium nitroprusside when surgical amputation appeared inevitable.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue 1 , February 1986 , pp. 72 - 74
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

References

REFERENCES

1.Friedman, AP. Headache. In: Baker, AB, Baker, LH, eds. Clinical Neurology, Vol 2. Hagerton MD: Harper and Row, 1983: 17–19.Google Scholar
2.Merhoff, GC, Porter, JM. Ergot intoxication: historical review and description of unusual clinical manifestations. Ann Surg 1974; 180: 773–778.CrossRefGoogle ScholarPubMed
3.Fedotin, MS, Hartman, C. Ergotamine poisoning producing renal arterial spasm. N Eng J Med 1970; 283: 518–519.CrossRefGoogle ScholarPubMed
4.Rail, TW, Schleifer, LS. Oxytocin, prostaglandins, ergot alkaloids, and other agents. In: Gilman, AG, Goodman, LS, Gilman, A, eds. The Pharmacological Basis of Therapeutics, Sixth Edition. New York: MacMillan Publishing Co., Inc., 1980: 939–947.Google Scholar
5.Carliner, NH, Denune, DP, Finch, CSet al. Sodium nitroprusside treatment of ergotamine-induced peripheral ischemia. JAMA 1974; 227: 308–309.CrossRefGoogle ScholarPubMed
6.Whitsett, TL. Nitroprusside reversal of ergotamine-induced ischemia. Am Heart J 1978; 96: 700.CrossRefGoogle ScholarPubMed