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A Review of Acrylamide Neurotoxicity Part II. Experimental Animal Neurotoxicity and Pathologic Mechanisms

Published online by Cambridge University Press:  18 September 2015

Peter S. Spencer*
Affiliation:
Department of Pathology (Neuropathol-ogy), The Saul R. Korey Department of Neurology and the Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, The Bronx, New York 10461, U.S.A.
Herbert H. Schaumburg
Affiliation:
Department of Pathology (Neuropathol-ogy), The Saul R. Korey Department of Neurology and the Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, The Bronx, New York 10461, U.S.A.
*
Dept. of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, N.Y., 10461, U.S.A.
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Abstract

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Type
Research Article
Copyright
Copyright © Canadian Neurological Sciences Federation 1974

References

Aguayo, A., Pryse-Phillips, W., (1974). Personal communication.Google Scholar
American Cyanamid Company (1952). New Products Bulletin, II collective, New York.Google Scholar
Ando, K. (1973). Study on the transport of acrylamide to the peripheral part of the rat sciatic nerve. Proceedings of the Osaka Prefectural Institute of Public Health No. 11, 4548, 1971.Google Scholar
Ando, K. and Hashimoto, K. (1972). Accumulation of (14-C) acrylamide in mouse nerve tissue. Proceedings of the Osaka Prefectural Institute of Public Health No. 10, 712.Google Scholar
Asbury, A. K., Cox, S.C. and Kanada, D. (1973). 3H leucine incorporation in acrylamide neuropathy in the mouse. Neurology 23, 406.Google Scholar
Asbury, A. K., Nielsen, S. L.Telfer, R. (1974). Glue sniffing neuropathy. Journal of Neuropathology and Experimental Neurology, 33, 191.Google Scholar
Barnes, J. M. (1969a). Toxic substances and the nervous system. Scientific Basis of Medicine Annual Reviews 183201.Google ScholarPubMed
Barnes, J. M. (1969b). Toxic chemicals and peripheral neuropathy. Proceedings of the Royal Society of Medicine 62, 205208.CrossRefGoogle ScholarPubMed
Barnes, J. M. (1970). Observations of the effects on rats of compounds related to acrylamide. British Journal of Industrial Medicine 27, 147149.Google ScholarPubMed
Bradley, W. G. and Asbury, A. K. (1970). Radioautographic studies of Schwann cell behavior. I. Acrylamide neuropathy in the mouse. Journal of Neuropathology and Experimental Neurology 29, 500506.CrossRefGoogle ScholarPubMed
Bradley, W. G. and Williams, M. H. (1973). Axoplasmic flow in axonal neuropathies — I. Axoplasmic flow in cats with toxic neuropathies. Brain 96, 235246.Google ScholarPubMed
Cavanagh, J. B. (1963). Organo-phosphorus neurotoxicity: a model “dying-back” process comparable to certain human neurological disorders. Guys Hospital Reports 112, 303319.Google Scholar
Cavanagh, J. B. (1964). The significance of the “dying-back” process in experimental and human neurological disease. International Review of Experimental Pathology 3, 219267.Google ScholarPubMed
Cavanagh, J. B. (1973). Peripheral neuropathy caused by chemical agents. CRC Critical Reviews in Toxicology 365417.Google ScholarPubMed
Chenoweth, M. B. (1955-1956). Personal communications quoted by Kuper-man, A. S. (1957).Google Scholar
Druckrey, H., Consbruch, U. and Schmähl, D. (1953). Effects of monomeric acrylamide on proteins. Zeitschrift für Naturforschung 86, 145150.CrossRefGoogle Scholar
Fullerton, P. M. (1969). Elec-trophysiological and histological observations on peripheral nerves in acrylamide poisoning in man. Journal of Neurology, Neurosurgery and Psychiatry 32, 186192.Google Scholar
Fullerton, P. M. and Barnes, J. M. (1966). Peripheral neuropathy in rats produced by acrylamide. British Journal of Industrial Medicine 23, 210221.Google ScholarPubMed
Ghetti, B. (1973). Personal communication.Google Scholar
Ghetti, B., Wisniewski, H. M., Cook, R. D., and Schaumburg, H. H. (1973). Changes in the CNS after acute and chronic acrylamide intoxication. American Journal of Pathology 70, 78A.Google Scholar
Gilliatt, R. W. (1969). Experimental peripheral neuropathy. Scientific Basis of Medicine Annual Reviews 202219.Google ScholarPubMed
Hamblin, D. O. (1956). The toxicity of acrylamide — a preliminary report. In: Hommage Au Doyen René Fabre, Membre De l'Institut, Professeur De Toxicologie À La Faculté De Pharmacie De Paris, 195199, S.E.D.E.S. Paris.Google Scholar
Hashimoto, K. and Aldridge, W. N. (1970). Biochemical studies on acrylamide: a neurotoxic agent. Biochemical Pharmacology 19, 25912604.CrossRefGoogle ScholarPubMed
Hashimoto, K. and Ando, K. (1971). Studies on acrylamide neuropathy. Effects on the permeability of amino acid into nervous tissues, distribution and metabolism. Proceedings of the Osaka Prefectural Institute of Public Health 9, 14.Google Scholar
Hashimoto, K. and Ando, K. (1973). Alteration of amino acid incorporation into proteins of the nervous system in vitro after administration of acrylamide to rats. Biochemical Pharmacology 22, 10571066.Google ScholarPubMed
Hazleton, L. W. (1951-1953). Unpublished studies quoted by A. S. Kuperman (1957).Google Scholar
Hopkins, A. P. (1968) Experimental neuropathy in the baboon. M.D. Thesis, University of London, London.Google Scholar
Hopkins, A. P. (1970). The effects of acrylamide on the peripheral nervous system of the baboon. Journal of Neurology. Neurosurgery and Psychiatry 33, 805816.Google ScholarPubMed
Hopkins, A. P. and Gilliatt, R. W. (1967). Acrylamide poisoning. British Medical Journal 4, 417.CrossRefGoogle ScholarPubMed
Hopkins, A. P. and Gilliatt, R. W. (1971). Motor and sensory conduction velocity in the baboon: normal values and changes during acrylamide neuropathy. Journal of Neurology, Neurosurgery and Psychiatry 34, 415426.Google ScholarPubMed
Hopkins, A. P. and Lambert, E. H. (1972). Conduction in unmyelinated fibers in experimental neuropathy. Journal of Neurology, Neurosurgery and Psychiatry 35, 163169.Google ScholarPubMed
Kaplan, M. L. and Murphy, S. D. (1972a). Modification of acrylamide neuropathy in rats by various factors. Toxicology and Applied Pharmacology, 22, 302303.Google Scholar
Kaplan, M. L. and Murphy, S. D. (1972b). Effect of acrylamide on rotarod performance and sciatic nerve β-glucuronidase activity of rats. Toxicology and Applied Pharmacology 22, 259268.Google ScholarPubMed
Kaplan, M. L., Murphy, S. D. and Gilles, F. H. (1973). Modification of acrylamide neuropathy in rats by selected factors. Toxicology and Applied Pharmacology 24, 564579.CrossRefGoogle ScholarPubMed
Kocen, R. S. and Thomas, P. K. (1971). Personal communication.Google Scholar
Kuperman, A. S. (1955-56). Unpublished studies, quoted by Kuperman, A. S. (1957).Google Scholar
Kuperman, A. S. (1957). The pharmacology of acrylamide. Ph.D. Thesis, Cornell University, New York.Google Scholar
Kuperman, A. S. (1958). Effects of acrylamide on the central nervous system of the cat. Journal of Pharmacology and Experimental Therapeutics 123, 180192.Google ScholarPubMed
Leswing, R. J. and Ribelin, W. E. (1969). Physiologic and pathologic changes in acrylamide neuropathy. Archives of Environmental Health 18, 2329.CrossRefGoogle ScholarPubMed
Mccollister, D. D., Oyen, F. and Rowe, V. K. (1964). Toxicology of acrylamide. Toxicology and Applied Pharmacology 6, 172181.CrossRefGoogle Scholar
Morgan-Hughes, J. S., Sinclair, S. and Thurston, J. H. J. (1974). The pattern of peripheral nerve regeneration induced by nerve crush in rats with severe acrylamide neuropathy. Brain 97, 215232.CrossRefGoogle ScholarPubMed
Ochoa, J. and Morgan-Hughes, J. A. (1974). Arrested peripheral nerve regeneration in acrylamide neuropathy. Proceedings VII International Congress of Neuropathology, Budapest.Google Scholar
Pleasure, D. E., Mischler, K. D.Engel, W. K. (1969). Axonal transport of proteins in experimental neuropathies. Science 166, 524525.CrossRefGoogle ScholarPubMed
Prineas, J. (1969a). The pathogenesis of dying-back polyneuropathies. I. An ultrastructural study of experimental tri-orthocresyl phosphate intoxication in the cat. Journal of Neuropathology and Experimental Neurology 28, 571597.CrossRefGoogle Scholar
Prineas, J. (1969b). The pathogenesis of dying-back polyneuropathies. II. An ultra-structural study of experimental acrylamide intoxication in the cat. Journal of Neuropathology and Experimental Neurology 28, 598621.CrossRefGoogle Scholar
Ribelin, W. E. (1964). Acrylamide toxicity. Special studies conducted by the pathology group. American Cyanamid Company Internal Memorandum (quoted by permission).Google Scholar
Riker, W. F. (1954). Summary of observations following single and repeated intravenous doses of acrylamide to cats. American Cyanamid Company Internal Memorandum (quoted by permission).Google Scholar
Schaumburg, H. H., Spencer, P.S., Wisniewski, H., Ghetti, B. and Cook, R. D. (1973). Experimental acrylamide neuropathy — a light microscopic, ultrastructural and clinical study. Journal of Neuropathology and Experimental Neurology 32, 171.Google Scholar
Schaumburg, H. H., Wisniewski, H. and Spencer, P. S. (1974). Ultrastructural studies of the dying-back process. I. Peripheral nerve terminal and axon degeneration in systemic acrylamide intoxication. Journal of Neuropathology and Experimental Neurology 33, 260284.CrossRefGoogle ScholarPubMed
Solnitzsky, O. (1953). Unpublished observations quoted by Kuperman, A.S. (1957).Google Scholar
Spencer, P.S. (1971). Light and electron microscopic observations on localised peripheral nerve injuries, 2 vols., Ph.D. Thesis, University of London, London.Google Scholar
Spencer, P.S. and Schaumburg, H. H. (1973). An ultrastructural study of the inner core of the Pacinian corpuscle. Journal of Neurocytology 2, 217235.CrossRefGoogle ScholarPubMed
Spencer, P. S. and Schaumburg, H. H. (1974). A review of acrylamide neurotoxicity, Part I. Properties, uses and human exposure. Canadian Journal of Neurological Sciences 1, 143150.Google ScholarPubMed
Spencer, P. S., Schaumburg, H. H., Raleigh, R. L. and Terhaar, C. J. (1974). Nervous system degeneration produced by the industrial solvent methyl butyl ketone. Archives of Neurology, in press.Google Scholar
Spencer, P. S. and Thomas, P. K. Ultrastructural studies of the dying-back process. 2. Schwann and oligodendroglial cell sequestration and removal of organelles for normal and diseased axons. Journal of Neurocytology, in press.Google Scholar
Stokinger, H. E. (1956). In: Recent Industrial Hygiene Developments in the Field of Toxicology. American Industrial Hygiene Association Quarterly 17, 340344.CrossRefGoogle Scholar
Sumner, A. J. and Asbury, A. K. (1974). Acrylamide neuropathy: selective vulnerability of sensory fibers. Archives of Neurology 30, abstract.Google Scholar
Suzuki, K. and De Paul, L. (1971). Degeneration and regeneration of sciatic nerves in rats treated with acrylamide. Journal of Neuropathology and Experimental Neurology 32, 170.Google Scholar
Suzuki, K. and Pfaff, L. (1973). Acrylamide neuropathy in rats. An electron microscopic study of degeneration and regeneration. Acta Neuropathologica 24, 197213.Google ScholarPubMed
Swift, T. and Lambert, E. H. (1974). Quoted by Tsujihata, M. et al. (1974).Google Scholar
Tsujihata, M., Engel, A. G. and Lambert, E. H. (1974). Neuromuscular junction ultrastructure in acrylamide “dying-back” neuropathy. A sequential morphometric study. Proceedings of the 26th annual meeting of the American Academy of Neurology, San Francisco.Google Scholar
West, R. (1959). American Cyanamid Company Interoffice Correspondence (quoted by permission).Google Scholar