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Vascular Headache: A Presenting Symptom of Multiple Sclerosis

Published online by Cambridge University Press:  18 September 2015

Mark S. Freedman  and
Trevor A. Gray
Mark S. Freedman
Affiliation:
University of Toronto, Department of Neurology, St. Michael's Hospital, Toronto
Trevor A. Gray*
Affiliation:
University of Toronto, Department of Neurology, St. Michael's Hospital, Toronto
*
University of Toronto, Department of Neurology, St. Michael's Hospital, M.S. Clinic, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
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Abstract:

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Vascular headache of migraine-type may be a presenting symptom of multiple sclerosis (MS), a condition usually not considered in the differential diagnosis of a severe headache accompanied by neurological signs. We reviewed records of 1,113 patients with MS seen from 1967-1987 and found 44 cases whose initial attack or subsequent exacerbations were heralded by a migraine-type headache. Twenty-seven patients had no prior history of migraine, and of these, 12 presented simultaneously with their first headache and MS attack. Twenty-three patients had symptoms of a posterior fossa mass lesion. The significance of these results and possible pathogenesis is discussed.

Information

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 16 , Issue 1 , February 1989 , pp. 63 - 66
Copyright
Copyright © Canadian Neurological Sciences Federation 1989

References

REFERENCES

1.Anonymous. Headache in multiple sclerosis. British Medical Journal [Editorial] 1969; 2: 713–714.CrossRefGoogle Scholar
2.Watkins, SM, Espir, M. Migraine and multiple sclerosis. J Neurol Neurosurg Psychiatry 1969; 2: 35–37.CrossRefGoogle Scholar
3.Rose, FC. Headache: definitions and classification. In: Vinke, PJ, Bruyn, GW, Klawans, HL, eds. Handbook of Clinical Neurology, vol. 48, rev. series 4: Headache. New York: Elsevier 1986; 1–12.Google Scholar
4.Poser, CM, Paty, DW, Scheinberg, L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983; 13: 227–231.CrossRefGoogle ScholarPubMed
5.Ziegler, DK. Epidemiology of migraine. In: Vinken, PJ, Bruyn, GW, eds. Handbook of Clinical Neurology, vol. 48, rev. series 4: Headache. New York: Elsevier 1986; 13–22.Google Scholar
6.Kurtzke, JF. Epidemiology of multiple sclerosis. In: Vinken, PJ, Bruyn, GW, Klawans, HL, eds. Handbook of Clinical Neurology, vol. 47, rev. series 3: Demyelinating Disease. New York: Elsevier 1985, 259–287.Google Scholar
7.Mathews, WB. Clinical aspects (symptoms and signs). In: Mathews, WB, ed. McAlpine’s Multiple Sclerosis. New York: Churchill Livingstone 1985; 96–118.Google Scholar
8.Kurtzke, JF. Clinical manifestations of multiple sclerosis. In: Vinken, PJ, Bruyn, GW, eds. Handbook of Clinical Neurology, vol. 9: Multiple Sclerosis and Other Demyelinating Diseases. New York: Elsevier 1970; 161–216.Google Scholar
9.Davies, PTG, Rose, FC. Migraine genetics. TINS 1986; 9: 541–542.Google Scholar
10.Edmeads, J. Complicated migraine and headache in cerebrovascular disease. Neurologic Clinics: Headache 1983; 1: 385–397.CrossRefGoogle Scholar
11.Sagar, HJ, Warlow, CP, Sheldon, PWE, et al. Multiple sclerosis with clinical and radiological features of cerebral tumour. J Neurol Neurosurg Psychiatry 1982; 45: 802–808.CrossRefGoogle ScholarPubMed
12.Edmeads, J. Migraine: new views on an old theory. Can J Neurol Sci 1984; 11: 363–364.CrossRefGoogle Scholar
13.Moskowitz, MA. The neurobiology of vascular head pain. Ann Neurol 1984; 16: 157–168.CrossRefGoogle ScholarPubMed
14.Adams, CWM, Poston, RN, Buk, SJ, et al. Inflammatory vasculitis in multiple sclerosis. J Neurol Sci 1985; 69: 269–283.CrossRefGoogle ScholarPubMed
15.Anthony, M. The biochemistry of migraine. In: Vinken, PJ, Bruyn, GW, Klawans, HL, eds. Handbook of Clinical Neurology, vol. 48, rev. series 4: Headache. New York: Elsevier 1986; 85–105.Google Scholar
16.Gawel, MJ, Burkitt, M, Rose, FC. The platelet release reaction during migraine attacks. Headache 1979; 19: 323–327.CrossRefGoogle ScholarPubMed
17.Wright, HP, Thompson, RHS, Zilkha, KJ. Platelet adhesiveness in multiple sclerosis. Lancet ii 1965; 1109–1110.CrossRefGoogle Scholar
18.Edmeads, J. Headache in cerebrovascular disease. In: Vinken, PJ, Bruyn, GW, Klawans, HL, eds. Handbook of Clinical Neurology, vol. 48, rev. series 4: Headache. New York: Elsevier 1986; 273–290.Google Scholar
19.Brandt, KD, Lessell, S. Migrainous phenomena in systemic lupus erythematosus. Arthritis Rheum 1978; 12: 7–16.CrossRefGoogle Scholar
20.Olsen, TS, Friberg, L, Lassen, NA. Ischemia may be the primary cause of neurologic deficits in classic migraine. Arch Neurol 1987; 44: 156–161.CrossRefGoogle Scholar
21.Olesen, J. The ischemic hypothesis of migraine. Arch Neurol 1987; 44: 321–322.CrossRefGoogle Scholar
22.Blau, JN. Migraine pathogenesis: the neural hypothesis reexamined. J Neurol Neurosurg Psychiatry 1984; 47: 437–442.CrossRefGoogle ScholarPubMed
23.Welch, KMA. Migraine: a biobehavioural disorder. Arch Neurol 1987; 44: 323–327.CrossRefGoogle Scholar
24.Damasio, H, Beck, D. Migraine, thrombocytopenia and serotonin metabolism. Lancet i: 1978; 240–243.CrossRefGoogle Scholar
25.Levine, SR, Welch, KMA. Cerebrovascular ischaemia associated with lupus anticoagulant. Stroke 1987; 18: 257–263.CrossRefGoogle ScholarPubMed
26.Correras, LO, Vermylen, JG. ‘Lupus’ anticoagulant and thrombosis: possible role of inhibition of prostacyclin formation. Thromb Haemost 1982; 48: 38–40.Google Scholar
27.Levine, SR, Joseph, R, D’Andrea, B, et al. Migraine and the lupus anticoagulant. Neurology 37 (Suppl 1) 1987; 264.Google Scholar
28.Tourtellotte, WW, Haerer, AF. Lipids in cerebrospinal fluid XXI. In multiple sclerosis and retrobulbar neuritis. Arch Neurol 1969; 20: 605–615.CrossRefGoogle Scholar
29.Zilkha, KJ. Chemistry of blood in multiple sclerosis. In: Vinken, PJ, Bruyn, GW, eds. Handbook of Clinical Neurology, vol. 9: Multiple Sclerosis and Other Demyelinating Disease. New York: Elsevier 1970; 320–323.Google Scholar