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Subgenual anterior cingulate responses to peer rejection: A marker of adolescents' risk for depression

Published online by Cambridge University Press:  24 January 2011

Carrie L. Masten*
Affiliation:
University of California, Los Angeles
Naomi I. Eisenberger
Affiliation:
University of California, Los Angeles
Larissa A. Borofsky
Affiliation:
University of Southern California
Kristin McNealy
Affiliation:
Duke University
Jennifer H. Pfeifer
Affiliation:
University of Oregon
Mirella Dapretto
Affiliation:
University of California, Los Angeles
*
Address correspondence and reprint requests to: Carrie L. Masten, c/o Naomi I. Eisenberger, Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095-1563; E-mail: cmasten@ucla.edu.

Abstract

Extensive developmental research has linked peer rejection during adolescence with a host of psychopathological outcomes, including depression. Moreover, recent neuroimaging research has suggested that increased activity in the subgenual region of the anterior cingulate cortex (subACC), which has been consistently linked with depression, is related to heightened sensitivity to peer rejection among adolescents. The goal of the current study was to directly test the hypothesis that adolescents' subACC responses are predictive of their risk for future depression, by examining the relationship between subACC activity during peer rejection and increases in depressive symptoms during the following year. During a functional magnetic resonance imaging scan, 20 13-year-olds were ostensibly excluded by peers during an online social interaction. Participants' depressive symptoms were assessed via parental reports at the time of the scan and 1 year later. Region of interest and whole-brain analyses indicated that greater subACC activity during exclusion was associated with increases in parent-reported depressive symptoms during the following year. These findings suggest that subACC responsivity to social exclusion may serve as a neural marker of adolescents' risk for future depression and have implications for understanding the relationship between sensitivity to peer rejection and the increased risk of depression that occurs during adolescence.

Type
Regular Articles
Copyright
Copyright © Cambridge University Press 2011

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References

Abecassis, M., Hartup, W. W., Haselager, G. J. T., Scholte, R. H. J., & Lieshout, C. F. M. (2002). Mutual antipathies and their developmental significance. Child Development, 73, 15431556.CrossRefGoogle Scholar
Achenbach, T. M., & Rescorla, L. A. (2001). Manual for the ASEBA School-Age Forms & Profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth & Families.Google Scholar
Brett, M., Anton, J. L., Valabregue, R., & Poline, J. B. (2002). Region of interest analysis using an SPM toolbox. NeuroImage, 16, 11401141.Google Scholar
Brody, A. L., Saxena, S., Silverman, D. H. S., Alborzian, S., Fairbanks, L. A., Phelps, M. E., et al. (1999). Brain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetine. Psychiatry Research, 91, 127139.CrossRefGoogle ScholarPubMed
Brown, B. B. (1990). Peer groups and peer cultures. In Feldman, S. S. & Elliot, G. R. (Eds.), At the threshold: The developing adolescent, pp. 171196. Cambridge, MA: Harvard University Press.Google Scholar
Carter, J. S., Garber, J., Ciesla, J. A., & Cole, D. A. (2006). Modeling relations between hassles and internalizing and externalizing symptoms in adolescents: A four-year prospective study. Journal of Abnormal Psychology, 115, 428442.CrossRefGoogle ScholarPubMed
Chen, C. H., Ridler, K., Suckling, J., Williams, S., Fu, C. H., Merlo-Pich, E., & Bullmore, E. (2007). Brain imaging correlates of depressive symptom severity and predictors of symptom improvement after antidepressant treatment. Biological Psychiatry, 62, 407414.CrossRefGoogle ScholarPubMed
Coie, J. D., Dodge, K. A., & Kupersmidt, J. B. (1990). Peer group behavior and social status. In Asher, S. R. & Coie, J. D. (Eds.), Peer rejection in childhood. Cambridge studies in social and emotional development (pp. 1759). New York: Cambridge University Press.Google Scholar
Csikszentmihalyi, M., & Larson, R. (1984). Being adolescent: Conflict and growth in the teenage years. New York: Basic Books.Google Scholar
Davidson, R. J., Irwin, W., Anderle, M. J., & Kalin, N. H. (2003). The neural substrates of affective processing in depressed patients treated with venlafaxine. American Journal of Psychiatry, 160, 6475.CrossRefGoogle ScholarPubMed
Eisenberger, N. I., Lieberman, M. D., Williams, K. D. (2003). Does rejection hurt? An fMRI study of social exclusion. Science, 302, 290292.CrossRefGoogle ScholarPubMed
French, D. C., Conrad, J., & Turner, T. M. (1995). Adjustment of antisocial and nonantisocial rejected adolescents. Development and Psychopathology, 7, 857874.CrossRefGoogle Scholar
Frith, C. D., & Frith, U. (1999). Interacting minds—a biological basis. Science, 286, 16921695.CrossRefGoogle ScholarPubMed
Frith, C. D., & Frith, U. (2006). How we predict what other people are going to do? Brain Research, 1079, 3646.CrossRefGoogle ScholarPubMed
Frith, U., & Frith, C. D. (2003). Development and neurophysiology of mentalizing. Philosophical Transactions of the Royal Society of London Series B, 358, 459473.CrossRefGoogle ScholarPubMed
Guyer, A. E., Lau, J. Y., McClure-Tone, E. B., Parrish, J., Shiffrin, N. D., Reynolds, R. C., et al. (2008). Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety. Archives of General Psychiatry, 65, 13031312.CrossRefGoogle ScholarPubMed
Guyer, A. E., McClure-Tone, E. B., Shiffrin, N. D., Pine, D. S., & Nelson, E. E. (2009). Probing the neural correlates of anticipated peer evaluation in adolescence. Child Development, 80, 10001015.CrossRefGoogle ScholarPubMed
Hammen, C., & Goodman-Brown, T. (1990). Self-schemas and vulnerability to specific life stress in children at risk for depression. Cognitive Therapy and Research, 14, 215227.CrossRefGoogle Scholar
Hankin, B. L., & Abramson, L. Y. (1999). Development of gender differences in depression: Description and possible explanations. Annals of Medicine, 31, 372379.CrossRefGoogle ScholarPubMed
Hankin, B. L., & Abramson, L. Y. (2001). Development of gender differences in depression: An elaborated cognitive vulnerability–transactional stress theory. Psychological Bulletin, 127, 773796.CrossRefGoogle ScholarPubMed
Hankin, B. L., Mermelstein, R., & Roesch, L. (2007). Sex differences in adolescent depression: Stress exposure and reactivity models. Child Development, 78, 279295.CrossRefGoogle ScholarPubMed
Juvonen, J., Graham, S., & Schuster, M. A. (2003). Bullying among young adolescents: The strong, the weak, and the troubled. Pediatrics, 112, 12311237.CrossRefGoogle ScholarPubMed
Klerman, G. L., & Weissman, M. M. (1989). Increasing rates of depression. Journal of the American Medical Association, 261, 22292235.CrossRefGoogle ScholarPubMed
Larson, R., & Ham, M. (1993). Stress and “storm and stress” in early adolescence: The relationship of negative events with dysphoric affect. Developmental Psychology, 29, 130140.CrossRefGoogle Scholar
Larson, R., Moneta, G., Richards, M., & Wilson, S. (2002). Continuity, stability, and change in daily emotional experience across adolescence. Child Development, 73, 11511165.CrossRefGoogle ScholarPubMed
Leadbeater, B. J., Kuperminc, G. P., Blatt, S. J., & Hertzog, C. (1999). A multivariate model of gender differences in adolescents' internalizing and externalizing problems. Developmental Psychology, 35, 12681282.CrossRefGoogle ScholarPubMed
Lev-Wiesel, R., Nuttman-Shwartz, O., & Sternberg, R. (2006). Peer rejection during adolescence: Psychological long-term effects—A brief report. Journal of Loss and Trauma, 11, 131142.CrossRefGoogle Scholar
Masten, C. L., Eisenberger, N. I., Borofsky, L. A., Pfeifer, J. H., McNealy, K., Mazziotta, J. C., et al. (2009). Neural correlates of social exclusion during adolescence: Understanding the distress of peer rejection. Social Cognitive Affective Neuroscience, 4, 143157.CrossRefGoogle ScholarPubMed
Mayberg, H. S. (2007). Defining the neural circuitry of depression: Toward a new nosology with therapeutic implications. Biological Psychiatry, 61, 729730.CrossRefGoogle Scholar
Mayberg, H. S., Brannan, S. K., Mahurin, R. K., Jerabek, P. A., Brickman, J. S., Tekell, J. L., et al. (1997). Cingulate function in depression: A potential predictor of treatment response. NeuroReport, 8, 10571061.CrossRefGoogle ScholarPubMed
Mitchell, J. P., Banaji, M. R., & Macrae, C. N. (2005). The link between social cognition and self-referential thought in the medial prefrontal cortex. Journal of Cognitive Neuroscience, 17, 13061315.CrossRefGoogle ScholarPubMed
Monk, C. S., McClure, E. B., Nelson, E. E., Zarahn, E., Bilder, R. M., Leibenluft, E., et al. (2003). Adolescent immaturity in attention-related brain engagement to emotional facial expressions. NeuroImage, 20, 420428.CrossRefGoogle ScholarPubMed
Nelson, E. E., Leibenluft, E., McClure, E. B., & Pine, D. S. (2005). The social re-orientation of adolescence: A neuroscience perspective on the process and its relation to psychopathology. Psychological Medicine, 35, 163174.CrossRefGoogle ScholarPubMed
Nolan, S. A., Flynn, C., & Garber, J. (2003). Prospective relations between rejection and depression in young adolescents. Journal of Personality and Social Psychology, 85, 745755.CrossRefGoogle ScholarPubMed
Nolen-Hoeksema, S., & Girgus, J. S. (1994). The emergence of gender differences in depression during adolescence. Psychological Bulletin, 115, 424443.CrossRefGoogle ScholarPubMed
Panak, W. F., & Garber, J. (1992). Role of aggression, rejection, and attributions in the prediction of depression in children. Development and Psychopathology, 4, 145165.CrossRefGoogle Scholar
Parkhurst, J. T., & Hopmeyer, A. (1998). Sociometric popularity and peer-perceived popularity: Two distinct dimensions of peer status. Journal of Early Adolescence, 18, 125144.CrossRefGoogle Scholar
Peterson, A. C., Compas, B. E., Brooks-Gunn, J., Stemmler, M., Ey, S., & Grant, K. E. (1993). Depression in adolescence. American Psychologist, 45, 513520.Google Scholar
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., et al. (2005). 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nature Neuroscience, 8, 828834.CrossRefGoogle ScholarPubMed
Pine, D. S., Cohen, P., Gurley, D., Brook, J., & Ma, Y. (1998). The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. Archives of General Psychiatry, 55, 5664.CrossRefGoogle ScholarPubMed
Pine, D. S., Cohen, P., Johnson, J. G., & Brook, J. S. (2002). Adolescent life events as predictors of adult depression. Journal of Affective Disorders, 68, 4957.CrossRefGoogle ScholarPubMed
Prinstein, M. J., & Aikins, J. W. (2004). Cognitive moderators of the longitudinal association between peer rejection and adolescent depressive symptoms. Journal of Abnormal Child Psychology, 32, 147158.CrossRefGoogle ScholarPubMed
Prinstein, M. J., Sheah, C. S., & Guyer, A. E. (2005). Peer victimization, cue interpretation, and internalizing symptoms: Preliminary concurrent and longitudinal findings for children and adolescents. Journal of Clinical Child and Adolescent Psychology, 34, 1124.CrossRefGoogle ScholarPubMed
Rigby, K. (2003). Consequences of bullying in schools. Canadian Journal of Psychiatry, 48, 583590.CrossRefGoogle ScholarPubMed
Rubin, K. H., Bukowski, W. M., & Parker, J. G. (2006). Peer interactions, relationships, and groups. In Eisenberg, N., Damon, W., & Lerner, R. M. (Eds.), Handbook of child psychology: Vol. 3. Emotional and personality development (6th ed., pp. 571652). Hoboken, NJ: Wiley.Google Scholar
Rudolph, K. D. (2002). Gender differences in emotional responses to interpersonal stress during adolescence. Journal of Adolescent Health, 30, 313.CrossRefGoogle ScholarPubMed
Rudolph, K. D., & Clark, A. G. (2001). Conceptions of relationships in children with depressive and aggressive symptoms: Social–cognitive distortion or reality? Journal of Abnormal Child Psychology, 29, 4156.CrossRefGoogle ScholarPubMed
Rudolph, K. D., & Conley, C. S. (2005). The socioemotional costs and benefits of social–evaluative concerns: Do girls care too much? Journal of Personality, 73, 115138.CrossRefGoogle ScholarPubMed
Rudolph, K. D., & Hammen, C. (1999). Age and gender as determinants of stress exposure, generation, and reactions in youngsters: A transactional perspective. Child Development, 70, 660677.CrossRefGoogle ScholarPubMed
Rudolph, K. D., Hammen, C., & Burge, D. (1994). Interpersonal functioning and depressive symptoms in childhood: Addressing the issues of specificity and comorbidity. Journal of Abnormal Child Psychology, 22, 355371.CrossRefGoogle ScholarPubMed
Rudolph, K. D., Hammen, C., Burge, D., Lindberg, N., Herzberg, D., & Daley, S. E. (2000). Toward an interpersonal life-stress model of depression: The developmental context of stress generation. Development and Psychopathology, 12, 215234.CrossRefGoogle ScholarPubMed
Sandstrom, M. J., Cillessen, A. H. N., & Eisenhower, A. (2003). Children's appraisal of peer rejection experiences: Impact on social and emotional adjustment. Social Development, 12, 530550.CrossRefGoogle Scholar
Saxena, S., Brody, A. L., Ho, M. L., Zohrabi, N., Maidment, K. M., & Baxter, L. R. (2003). Differential brain metabolic predictors of response to paroxetine in obsessive–compulsive disorder versus major depression. American Journal of Psychiatry, 160, 522532.CrossRefGoogle ScholarPubMed
Steinberg, L. (2008). A neurobehavioral perspective on adolescent risk-taking. Developmental Review, 28, 78106.CrossRefGoogle Scholar
Wagner, B. M., & Compas, B. E. (1990). Gender, instrumentality, and expressivity: Moderates of the relation between stress and psychological symptoms during adolescence. American Journal of Community Psychology, 18, 383406.CrossRefGoogle ScholarPubMed
Weissman, M. M., & Klerman, G. L. (1977). Sex differences and the epidemiology of depression. Archives of General Psychiatry, 34, 98111.CrossRefGoogle ScholarPubMed
Williams, K. D., Cheung, C. K., Choi, W. (2000). CyberOstracism: Effects of being ignored over the internet. Journal of Personality and Social Psychology, 79, 748762.CrossRefGoogle Scholar
Williams, K. D., Goven, C. L., Croker, V., Tynan, D., Cruickshank, M., & Lam, A. (2002). Investigations into differences between social- and cyberostracism. Group Dynamics, 6, 6577.CrossRefGoogle Scholar
Wolk, S. I., & Weissman, M. M. (1995). Women and depression: An update. Review of Psychiatry, 14, 227259.Google Scholar