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Take your mind off it: Coping style, serotonin transporter linked polymorphic region genotype (5-HTTLPR), and children's internalizing and externalizing problems

Published online by Cambridge University Press:  06 October 2015

Jessie I. Cline
Affiliation:
University of Pennsylvania
Jay Belsky
Affiliation:
University of California, Davis
Zhi Li
Affiliation:
University of California, Davis
Edward Melhuish
Affiliation:
University of London Oxford University
Laura Lysenko
Affiliation:
King's College London
Tara McFarquhar
Affiliation:
University College London Anna Freud Centre
Suzanne Stevens
Affiliation:
University of Auckland
Sara R. Jaffee*
Affiliation:
University of Pennsylvania
*
Address correspondence and reprint requests to: Sara R. Jaffee, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104; E-mail: srjaffee@psych.upenn.edu.

Abstract

Individuals with the short variant of the serotonin transporter linked polymorphic region gene are more susceptible than individuals homozygous for the long allele to the effects of stressful life events on risk for internalizing and externalizing problems. We tested whether individual differences in coping style explained this increased risk for problem behavior among youth who were at both genetic and environmental risk. Participants included 279 children, ages 8–11, from the Children's Experiences and Development Study. Caregivers and teachers reported on children's internalizing and externalizing symptoms, and caregivers and children on children's exposure to harsh parenting and parental warmth in middle childhood, and traumatic events. Children reported how frequently they used various coping strategies. Results revealed that short/short homozygotes had higher levels of internalizing problems compared with long allele carriers and that short allele carriers had higher levels of externalizing problems compared with long/long homozygotes under conditions of high cumulative risk. Moreover, among children who were homozygous for the short allele, those who had more cumulative risk indicators less frequently used distraction coping strategies, which partly explained why they had higher levels of internalizing problems. Coping strategies did not significantly mediate Gene × Environment effects on externalizing symptoms.

Type
Special Section Articles
Copyright
Copyright © Cambridge University Press 2015 

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References

Alexander, N., Klucken, T., Koppe, G., Osinsky, R., Walter, B., Vaitl, D., et al. (2012). Interaction of the serotonin transporter-linked polymorphic region and environmental adversity: Increased amygdala–hypothalamus connectivity as a potential mechanism linking neural and endocrine hyperreactivity. Biological Psychiatry, 72, 4956.CrossRefGoogle ScholarPubMed
Alexander, N., Kuepper, Y., Schmitz, A., Osinsky, R., Kozyra, E., & Hennig, J. (2009). Gene–environment interactions predict cortisol responses after acute stress: Implications for the etiology of depression. Psychoneuroendocrinology, 34, 12941303.CrossRefGoogle Scholar
Angold, A., Costello, E. J., & Erkanli, A. (1999). Comorbidity. Journal of Child Psychology and Psychiatry, 40, 5787. doi:http://dx.doi.org/10.1111/1469-7610.00424 CrossRefGoogle ScholarPubMed
Åslund, C., Leppert, J., Comasco, E., Nordquist, N., Oreland, L., & Nilsson, K. W. (2009). Impact of the interaction between the 5-HTTLPR polymorphism and maltreatment on adolescent depression: A population-based study. Behavior Genetics, 39, 524531. doi: 10.1007/s10519-009-9285-9 CrossRefGoogle Scholar
Ayers, T. S., Sandler, I. N., West, S. G., & Roosa, M. W. (1996). A dispositional and situational assessment of children's coping: Testing alternative models of coping. Journal of Personality, 64, 923958. doi:10.1111/j.1467-6494.1996.tb00949.x CrossRefGoogle ScholarPubMed
Beevers, C. G., Wells, T. T., Ellis, A. J., & McGeary, J. E. (2009). Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli. Journal of Abnormal Psychology, 118, 670681.CrossRefGoogle ScholarPubMed
Beitchman, J., Baldassarra, L., Mik, H., De Luca, V., King, N., Bender, D., et al. (2006). Serotonin transporter polymorphisms and persistent, pervasive childhood aggression. American Journal of Psychiatry, 163, 11031105.CrossRefGoogle ScholarPubMed
Belsky, J., Bakermans-Kranenburg, M., & van Ijzendoorn, M. (2007). For better and for worse: Differential susceptibility to environmental influences. Current Directions in Psychological Science, 16, 305309.CrossRefGoogle Scholar
Belsky, J., Jonassaint, C., Pluess, M., Stanton, M., Brummet, B., & Williams, R. (2009). Vulnerability genes or plasticity genes? Molecular Psychiatry, 14, 746754.CrossRefGoogle ScholarPubMed
Belsky, J., Melhuish, E., Barnes, J., Leyland, A. H., Romaniuk, H., & National Evaluation of Sure Start Research Team. (2006). Effects of Sure Start local programmes on children and families: Early findings from a quasi-experimental cross sectional study. British Medical Journal, 332, 14761478.CrossRefGoogle ScholarPubMed
Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135, 885908.CrossRefGoogle ScholarPubMed
Belsky, J., & Pluess, M. (2013). Beyond risk, resilience and dysregulation: Phenotypic plasticity and human development. Development and Psychopathology, 25, 12431261.CrossRefGoogle ScholarPubMed
Belsky, J., Pluess, M., & Widaman, K. F. (2013). Confirmatory and competitive evaluation of alternative gene-environment interaction hypotheses. Journal of Child Psychology and Psychiatry, 54, 11351143.CrossRefGoogle ScholarPubMed
Bollen, K., & Lenox, R. (1991). Conventional wisdom on measurement: A structural equation perspective. Psychological Bulletin, 110, 305314.CrossRefGoogle Scholar
Canli, T., Qiu, M., Omura, K., Congdon, E., Haas, B. W., Amin, Z., et al. (2006). Neural correlates of epigenesis. PNAS, 103, 1603316038.CrossRefGoogle ScholarPubMed
Caron, C., & Rutter, M. (1991). Comorbidity in child psychopathology: Concepts, issues, and research strategies. Journal of Child Psychology and Psychiatry, 32, 10631080.CrossRefGoogle ScholarPubMed
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., et al. (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297, 851854.CrossRefGoogle ScholarPubMed
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., et al. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386389. doi:10.1126/science.1083968CrossRefGoogle ScholarPubMed
Cicchetti, D., Rogosch, F. A., & Sturge-Apple, M. L. (2007). Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: Depressive symptomatology among adolescents from low socioeconomic status backgrounds. Development and Psychopathology, 19, 11611180. doi:10.1017/S0954579407000600 CrossRefGoogle ScholarPubMed
Compas, B. E. (2006). Psychobiological processes of stress and coping: Implications for resilience in children and adolescents—Comments on the papers by Romeo & McEwen and Fisher et al. Annals of the New York Academy of Sciences, 1094, 226234.CrossRefGoogle ScholarPubMed
Compas, B. E., Connor-Smith, J. K., Saltzman, H., Thomsen, A. H., & Wadsworth, M. E. (2001). Coping with stress during childhood and adolescence: Problems, progress, and potential in theory and research. Psychological Bulletin, 127, 87127.CrossRefGoogle ScholarPubMed
Conger, R., Wallace, L., Sun, Y., McLoyd, V., & Brody, G. (2002). Economic pressure in African-American families: A replication and extension of the family stress model. Developmental Psychology, 38, 179193.CrossRefGoogle ScholarPubMed
Connor-Smith, J. K., Compas, B. E., Wadsworth, M. E., Harding Thomsen, A., & Saltzman, H. (2000). Responses to stress in adolescence: Measurement of coping and involuntary stress responses. Journal of Consulting and Clinical Psychology, 68, 976992.CrossRefGoogle ScholarPubMed
Conway, C. C., Hammen, C., Espejo, E. P., Wray, N. R., Najman, J. M., & Brennan, P. A. (2012). Appraisals of stressful life events as a genetically-linked mechanism in the stress–depression relationship. Cognitive Therapy and Research, 36, 338347.CrossRefGoogle Scholar
Conway, C. C., Keenan-Miller, D., Hammen, C., Lind, P. A., Najman, J. M., & Brennan, P. A. (2012). Coaction of stress and serotonin transporter genotype in predicting aggression at the transition to adulthood. Journal of Clinical Child and Adolescent Psychology, 41, 5363.CrossRefGoogle ScholarPubMed
Craft, L. L., & Landers, D. M. (1998). The effect of exercise on clinical depression and depression resulting from mental illness: A meta-analysis. Journal of Sport & Exercise Psychology, 20, 339357.CrossRefGoogle Scholar
Davidge, K. M., Atkinson, L., Douglas, L., Lee, V., Shapiro, S., Kennedy, J. L., et al. (2004). Association of the serotonin transporter and 5HT1Dβ receptor genes with extreme, persistent and pervasive aggressive behaviour in children. Psychiatric Genetics, 14, 143146. doi:10.1097/00041444-200409000-00004 CrossRefGoogle ScholarPubMed
Davies, P. T., & Cicchetti, D. (2014). How and why does the 5-HTTLPR gene moderate associations between maternal unresponsiveness and children's disruptive problems? Child Development, 85, 484500.CrossRefGoogle ScholarPubMed
Drabick, D. A. (2009). Can a developmental psychopathology perspective facilitate a paradigm shift toward a mixed categorical-dimensional classification system? Clinical Psychology: Science and Practice, 16, 4149.Google Scholar
Ebata, A. T., & Moos, R. H. (1991). Coping and adjustment in distressed and healthy adolescents. Journal of Applied Developmental Psychology, 12, 3354. doi:10.1016/0193-3973(91)90029-4 CrossRefGoogle Scholar
Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2011). Differential susceptibility to the environment: A neurodevelopmental theory. Development and Psychopathology, 23, 728.CrossRefGoogle ScholarPubMed
Evans, G. W. (2004). The environment of childhood poverty. American Psychologist, 59, 7792.CrossRefGoogle ScholarPubMed
Evans, G. W., Li, D., & Whipple, S. S. (2013). Cumulative risk and child development. Psychological Bulletin, 139, 13421396.CrossRefGoogle ScholarPubMed
Fear, J. M., Champion, J. E., Reeslund, K. L., Forehand, R., Colletti, C., Roberts, L., et al. (2009). Parental depression and interparental conflict: Children and adolescents' self-blame and coping responses. Journal of Family Psychology, 23, 762766.CrossRefGoogle ScholarPubMed
Forns, M., Balluerka, N., Gomez-Benito, J., Kirchner, T., & Amador, J. A. (2010). Multilevel approach to stressors, coping, and psychopathological symptoms. Psychological Reports, 106, 262278.CrossRefGoogle ScholarPubMed
Freeman, B., Curtis, C., Huckett, L., Mill, J., & Craig, I. W. (2003). DNA from buccal swabs recruited by mail: Evaluation of storage effects on long-term stability and suitability for multiplex polymerase chain reaction and genotyping. Behavior Genetics, 33, 6772.CrossRefGoogle ScholarPubMed
Gadow, K. D., & Sprafkin, J. (2005). Child and Adolescent Symptom Inventory—4 Revised (CASI-4R). Stony Brook, NY: Checkmate Plus.Google Scholar
Garbarino, J., Kostelny, K., & Dubrow, N. (1991). What children can tell us about living in danger. American Psychologist, 46, 376383. doi:10.1037/0003-066X.46.4.376 CrossRefGoogle ScholarPubMed
Gerra, G., Garofano, L., Castaldini, L., Rovetto, F., Zaimovic, A., Moi, G., et al. (2005). Serotonin transporter promoter polymorphism genotype is associated with temperament, personality traits and illegal drugs use among adolescents. Journal of Neural Transmission, 112, 13971410.CrossRefGoogle ScholarPubMed
Gibb, B. E., Beevers, C. G., & McGeary, J. E. (2013). Toward an integration of cognitive and genetic models of risk for depression. Cognition & Emotion, 27, 193216.CrossRefGoogle ScholarPubMed
Gonzales, N. A., Tein, J., Sandler, I. N., & Friedman, R. J. (2001). On the limits of coping: Interaction between stress and coping for inner-city adolescents. Journal of Adolescent Research, 16, 372395. doi:10.1177/0743558401164005 CrossRefGoogle Scholar
Grant, K. E., O'Koon, J. H., Davis, T. H., Roache, N. A., Poindexter, L. M., Armstrong, M. L., et al. (2000). Protective factors affecting low-income urban African American youth exposed to stress. Journal of Early Adolescence, 20, 388417.CrossRefGoogle Scholar
Greenberg, B. D., Tolliver, T. J., Huang, S., Li, Q., Bengel, D., & Murphy, D. L. (1999). Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. American Journal of Medical Genetics, 88, 8387.3.0.CO;2-0>CrossRefGoogle ScholarPubMed
Haberstick, B. C., Smolen, A., & Hewitt, J. K. (2006). Family-based association test of the 5-HTTLPR and aggressive behavior in a general population sample of children. Biological Psychiatry, 59, 836843. doi:10.1016/j.biopsych.2005.10.008 CrossRefGoogle Scholar
Hayden, E. P., Olino, T. M., Bufferd, S. J., Miller, A., Dougherty, L. R., Sheikh, H. I., et al. (2013). The serotonin transporter linked polymorphic region and brain-derived neurotrophic factor valine to methionine at position 66 polymorphisms and maternal history of depression: Associations with cognitive vulnerability to depression in childhood. Development and Psychopathology, 25, 587598.CrossRefGoogle ScholarPubMed
Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., et al. (1996). Allelic variation of human serotonin transporter gene expression. Journal of Neurochemistry, 66, 26212624. doi:10.1046/j.1471-4159.1996.66062621.x CrossRefGoogle ScholarPubMed
Jaffee, S. R., McFarquhar, T., Stevens, S., Ouellet-Morin, I., Melhuish, E., & Belsky, J. (2015). Interactive effects of early and recent exposure to stressful contexts on cortisol reactivity in middle childhood. Journal of Child Psychology and Psychiatry, 56, 138146.CrossRefGoogle ScholarPubMed
Jaser, S., Fear, J., Reeslund, K., Champion, J., Reising, M., & Compas, B. (2008). Maternal sadness and adolescents' responses to stress in offspring of mothers with and without a history of depression. Journal of Clinical Child and Adolescent Psychology, 37, 736746.CrossRefGoogle ScholarPubMed
Jaser, S. S., Langrock, A. M., Keller, G., Merchant, M. J., Benson, M. A., Reeslund, K., et al. (2005). Coping with the stress of parental depression: II. Adolescent and parent reports of coping and adjustment. Journal of Clinical Child and Adolescent Psychology, 34, 193205.CrossRefGoogle ScholarPubMed
Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation. Archives of General Psychiatry, 68, 444454.CrossRefGoogle ScholarPubMed
Kaufman, J., Yang, B., Douglas-Palumberi, H., Houshyar, S., Lipschitz, D., Krystal, J. H., et al. (2004). Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences, 101, 1731617321. doi:10.1073/pnas.0404376101CrossRefGoogle ScholarPubMed
Klein, D. N., & Riso, L. P. (1993). Psychiatric disorders: Problems of boundaries and comorbidity. In Costello, C. G. (Ed.), Basic issues in psychopathology (pp. 1926). New York: Guilford Press.Google Scholar
Klucken, T., Alexander, N., Schweckendiek, J., Merz, C. J., Kagerer, S., Osinsky, R., et al. (2013). Individual differences in neural correlates of fear conditioning as a function of 5-HTTLPR and stressful life events. Social Cognitive and Affective Neuroscience, 8, 318325.CrossRefGoogle ScholarPubMed
Lazarus, R. S., & Folkman, S. (1984). Stress, appraisal, and coping. New York: Springer.Google Scholar
Lesch, K. P., Bengel, D., Heils, A., Sabol, S., Greenberg, B., Petri, S., et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 15271531.CrossRefGoogle ScholarPubMed
Lucki, I. (1998). The spectrum of behaviors influenced by serotonin. Biological Psychiatry, 44, 151162.CrossRefGoogle ScholarPubMed
Lyons-Ruth, K., Holmes, B. M., Sasvari-Szekely, M., Ronai, Z., Nemoda, Z., & Pauls, D. (2007). Serotonin transporter polymorphism and borderline or antisocial traits among low-income young adults. Psychiatric Genetics, 17, 339343. doi:10.1097/YPG.0b013e3281ac237e CrossRefGoogle ScholarPubMed
Maes, M., & Meltzer, H. (1995). The serotonin hypothesis of major depression. In Bloom, F. E. & Kupfer, D. J. (Eds.), Psychopharmacology: The fourth generation of progress (pp. 933944). New York: Raven Press.Google Scholar
Margolin, G., & Gordis, E. B. (2000). The effects of family and community violence on children. Annual Review of Psychology, 51, 445479. doi:10.1146/annurev.psych.51.1.445 CrossRefGoogle Scholar
Marmorstein, N. R. (2007). Relationships between anxiety and externalizing disorders in youth: The influences of age and gender. Journal of Anxiety Disorders, 21, 420432. doi:10.1016/j.janxdis.2006.06.004 CrossRefGoogle ScholarPubMed
Miller, R., Wankerl, M., Stalder, T., Kirschbaum, C., & Alexander, N. (2013). The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cortisol stress reactivity: A meta-analysis. Molecular Psychiatry, 18, 10181024.CrossRefGoogle ScholarPubMed
Miu, A. C., Vulturar, R., Chis, A., Ungureanu, L., & Gross, J. J. (2013). Reappraisal as a mediator in the link between 5-HTTLPR and social anxiety symptoms. Emotion, 13, 10121022.CrossRefGoogle ScholarPubMed
Moeller, F. G., Allen, T., Cherek, D. R., Dougherty, D. M., Lane, S., & Swann, A. C. (1998). Ipsapirone neuroendocrine challenge: Relationship to aggression as measured in the human laboratory. Psychiatry Research, 81, 3138. doi:10.1016/S0165-1781(98)00081-X CrossRefGoogle ScholarPubMed
Mor, N., & Winquist, J. (2002). Self-focused attention and negative affect: A meta-analysis. Psychological Bulletin, 128, 638662.CrossRefGoogle ScholarPubMed
Morgan, A. B., & Lilienfeld, S. O. (2000). A meta-analytic review of the relation between antisocial behavior and neuropsychological measures of executive function. Clinical Psychology Review, 20, 113136.CrossRefGoogle ScholarPubMed
Mueller, A., Armbruster, D., Moser, D. A., Canli, T., Lesch, K. P., Brocke, B., et al. (2011). Interaction of serotonin transporter gene-linked polymorphic region and stressful life events predicts cortisol stress response. Neuropsychopharmacology, 36, 13321339.CrossRefGoogle ScholarPubMed
Munafò, M. R., Brown, S. M., & Hariri, A. R. (2008). Serotonin transporter (5-HTTLPR) genotype and amygdala activation: A meta-analysis. Biological Psychiatry, 63, 852857.CrossRefGoogle ScholarPubMed
Munafò, M. R., Durrant, C., Lewis, G., & Flint, J. (2009). Gene x environment interactions at the serotonin transporter locus. Biological Psychiatry, 65, 211219.CrossRefGoogle ScholarPubMed
Neumeister, A., Konstantinidis, A., Stastny, J., Schwarz, M. J., Vitouch, O., Willeit, M., et al. (2002). Association between serotonin transporter gene promoter polymorphism (5-HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression. Archives of General Psychiatry, 59, 613620. doi:10.1001/archpsyc.59.7.613 CrossRefGoogle Scholar
Nicolotti, L., El-Sheikh, M., & Whitson, S. A. (2003). Children's coping with marital conflict and their adjustment and physical health: Vulnerability and protective functions. Journal of Family Psychology, 17, 315326.CrossRefGoogle ScholarPubMed
Nolen-Hoeksema, S., Wisco, B. E., & Lyubomirsky, S. (2008). Rethinking rumination. Perspectives on Psychological Science, 3, 400424.CrossRefGoogle ScholarPubMed
Program for Prevention Research. (1999). Manual for the Children's Coping Strategies Checklist and the How I Coped Under Pressure Scale. Tempe, AZ: Arizona State University.Google Scholar
Reif, A., Rösler, M., Freitag, C. M., Schneider, M., Eujen, A., Kissling, C., et al. (2007). Nature and nurture predispose to violent behavior: Serotonergic genes and adverse childhood environment. Neuropsychopharmacology, 32, 23752383. doi:10.1038/sj.npp.1301359 CrossRefGoogle ScholarPubMed
Retz, W., Freitag, C. M., Retz-Junginger, P., Wenzler, D., Schneider, M., Kissling, C., et al. (2008). A functional serotonin transporter promoter gene polymorphism increases ADHD symptoms in delinquents: Interaction with adverse childhood environment. Psychiatry Research, 158, 123131. doi:10.1016/j.psychres.2007.05.004 CrossRefGoogle ScholarPubMed
Retz, W., Retz-Junginger, P., Supprian, T., Thome, J., & Rösier, M. (2004). Association of serotonin transporter promoter gene polymorphism with violence: Relation with personality disorders, impulsivity, and childhood ADHD psychopathology. Behavioral Sciences & the Law, 22, 415425. doi:10.1002/bsl.589 CrossRefGoogle ScholarPubMed
Ribbe, D. (1996). Psychometric review of Traumatic Event Screening Instrument for Children (TESI-C). In Stamm, B. H. (Ed.), Measurement of stress, trauma, and adaptation (pp. 386387). Lutherville, MD: Sidran Press.Google Scholar
Rimer, J., Dwan, K., Lawlor, D. A., Greig, C. A., McMurdo, M., Morley, W., et al. (2012). Exercise for depression. Cochrane Database of Systematic Reviews, CD004366. doi:10.1002/14651858.CD004366.pub5 CrossRefGoogle Scholar
Risch, N., Herrell, R., Lehner, T., Liang, K. Y., Eaves, L., Hoh, J., et al. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis. Journal of the American Medical Association, 301, 24622471.CrossRefGoogle ScholarPubMed
Roisman, G. I., Newman, D. A., Fraley, R. C., Haltigan, J. D., Groh, A. M., & Haydon, K. C. (2012). Distinguishing differential susceptibility from diathesis–stress: Recommendations for evaluating interaction effects. Development and Psychopathology, 24, 389409. doi:10.1017/S0954579412000065 CrossRefGoogle ScholarPubMed
Russo, M. F., & Beidel, D. C. (1994). Comorbidity of childhood anxiety and externalizing disorders: Prevalence, associated characteristics, and validation issues. Clinical Psychology Review, 14, 199221. doi:10.1016/0272-7358(94)90008-6 CrossRefGoogle Scholar
Sanchez, Y. M., Lambert, S. F., & Cooley-Strickland, M. (2013). Adverse life events, coping and internalizing and externalizing behaviors in urban African American youth. Journal of Child and Family Studies, 22, 3847. doi:10.1007/s10826-012-9590-4 CrossRefGoogle Scholar
Sandler, I. N., Tein, J., & West, S. G. (1994). Coping, stress, and the psychological symptoms of children of divorce: A cross-sectional and longitudinal study. Child Development, 65, 17441763. doi:10.2307/1131291 CrossRefGoogle ScholarPubMed
Shelton, K. K., Frick, P. J., & Wooton, J. (1996). Assessment of parenting practices in families of elementary school-age children. Journal of Clinical Child Psychology, 25, 317329.CrossRefGoogle Scholar
Simons, R. L., Lei, M. K., Beach, S. R. H., Brody, G. H., Philibert, R. A., & Gibbons, F. X. (2011). Social environment, genes, and aggression: Evidence supporting the differential susceptibility perspective. American Sociological Review, 76, 883912. doi:10.1177/0003122411427580 CrossRefGoogle Scholar
Sugden, K., Arseneault, L., Harrington, H., Moffitt, T. E., Williams, B., & Caspi, A. (2010). Serotonin transporter gene moderates the development of emotional problems among children following bullying victimization. Journal of the American Academy of Child & Adolescent Psychiatry, 49, 830840. doi:10.1016/j.jaac.2010.01.024 CrossRefGoogle ScholarPubMed
Szily, E., Bowen, J., Unoka, Z., Simon, L., & Kéri, S. (2008). Emotion appraisal is modulated by the genetic polymorphism of the serotonin transporter. Journal of Neural Transmission, 115, 819822.CrossRefGoogle ScholarPubMed
Taylor, S. E., & Stanton, A. L. (2007). Coping resources, coping processes, and mental health. Annual Review of Clinical Psychology, 3, 377401.CrossRefGoogle ScholarPubMed
Taylor, S. E., Way, B. M., Welch, W. T., Hilmert, C. J., Lehman, B. J., & Eisenberger, N. I. (2006). Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology. Biological Psychiatry, 60, 671676. doi:10.1016/j.biopsych.2006.04.019 CrossRefGoogle ScholarPubMed
Tobin, D. L., Holroyd, K. A., Reynolds, R. V., & Wigal, J. K. (1989). The hierarchical factor structure of the coping strategies inventory. Cognitive Therapy and Research, 13, 343361.CrossRefGoogle Scholar
van IJzendoorn, M. H., Belsky, J., & Bakermans-Kranenburg, M. (2012). Serotonin transporter genotype 5HTTLPR as a marker of differential susceptibility? A meta-analysis of child and adolescent gene-by-environment studies. Translational Psychiatry, 2, e2.CrossRefGoogle ScholarPubMed
Verona, E., Joiner, T. E., Johnson, F., & Bender, T. W. (2006). Gender specific gene-environment interactions on laboratory-assessed aggression. Biological Psychology, 71, 3341. doi:10.1016/j.biopsycho.2005.02.001 CrossRefGoogle ScholarPubMed
Verona, E., & Patrick, C. J. (2000). Suicide risk in externalizing syndromes: Temperamental and neurobiological underpinnings. In Joiner, T. & Rudd, M. D. (Eds.), Suicide science: Expanding the boundaries (pp. 137173). New York: Kluwer Academic/Plenum Press.Google Scholar
Wadsworth, M. E., Raviv, T., Santiago, C. D., & Etter, E. M. (2011). Testing the adaptation to poverty-related stress model: Predicting psychopathology symptoms in families facing economic hardship. Journal of Clinical Child and Adolescent Psychology, 40, 646657.CrossRefGoogle ScholarPubMed
Weisz, J. R., Francis, S. E., & Bearman, S. K. (2010). Assessing secondary control and its association with youth depression symptoms. Journal of Abnormal Child Psychology, 38, 883893.CrossRefGoogle ScholarPubMed
Weisz, J. R., Mccabe, M. A., & Dennig, M. D. (1994). Primary and secondary control among children undergoing medical procedures: Adjustment as a function of coping style. Journal of Consulting and Clinical Psychology, 62, 324332.CrossRefGoogle ScholarPubMed
Widaman, K. F., Helm, J. L., Castro-Schilo, L., Pluess, M., Stallings, M. C., & Belsky, J. (2012). Distinguishing ordinal and disordinal interactions. Psychological Methods, 17, 615622.CrossRefGoogle ScholarPubMed
Wilhelm, K., Siegel, J. E., Finch, A. W., Hadzi-Pavlovic, D., Mitchell, P. B., Parker, G., et al. (2007). The long and the short of it: Associations between 5-HTT genotypes and coping with stress. Psychosomatic Medicine, 69, 614620.CrossRefGoogle Scholar
Williams, L. M., Gatt, J. M., Schofield, P. R., Olivieri, G., Peduto, A., & Gordon, E. (2009). “Negativity bias” in risk for depression and anxiety: Brain–body fear circuitry correlates, 5-HTT-LPR and early life stress. NeuroImage, 47, 804814.CrossRefGoogle ScholarPubMed
Zalsman, G., Frisch, A., Bromberg, M., Gelernter, J., Michaelovsky, E., Campino, A., et al. (2001). Family-based association study of serotonin transporter promoter in suicidal adolescents: No association with suicidality but possible role in violence traits. American Journal of Medical Genetics, 105, 239245.CrossRefGoogle ScholarPubMed
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Take your mind off it: Coping style, serotonin transporter linked polymorphic region genotype (5-HTTLPR), and children's internalizing and externalizing problems
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