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Childhood parenting and adolescent internalizing and externalizing symptoms: Moderation by multilocus hypothalamic–pituitary–adrenal axis-related genetic variation

Published online by Cambridge University Press:  31 January 2022

Cong Cao Open the ORCID record for Cong Cao [Opens in a new window]  and
Jolien Rijlaarsdam Open the ORCID record for Jolien Rijlaarsdam [Opens in a new window]
Cong Cao
Affiliation:
Department of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, China
Jolien Rijlaarsdam*
Affiliation:
Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands
*
Corresponding author: Jolien Rijlaarsdam, email: j.rijlaarsdam@erasmusmc.nl
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Abstract

Genetic variants that regulate hypothalamic–pituitary–adrenal (HPA) axis function have been demonstrated to moderate the association between parenting and mental health. However, extant research has focused primarily on (i) effects of individual genes or (ii) maternal as opposed to paternal parenting. Using a multilocus genetic profile score (MGPS) approach, the current study is the first to examine the moderation effect of multilocus HPA-axis related genetic variants on the association of both maternal and paternal parenting with adolescent internalizing and externalizing symptoms. In a sample of 772 Chinese Han adolescents (M age = 16.48 ± 1.40 years; 50.1% girls), a theory-driven MGPS was calculated using six polymorphisms within HPA-axis related genes (CRHR1, NR3C1, NR3C2, FKBP5, COMT, and HT1RA). Results showed that the MGPS interacted with both maternal and paternal parenting in the association with adolescent internalizing symptoms, but not externalizing symptoms. Consistent with the differential susceptibility model, adolescents with high versus low MGPS exhibited not only more internalizing symptoms when exposed to low quality of parenting but also less internalizing symptoms when exposed to high quality of parenting. The current findings highlight the potential value of using a multilocus approach to understanding gene-by-environment interaction (G×E) effects underlying mental health. Within such G×E effects, not only maternal but also paternal parenting should be addressed.

Keywords

gene-by-environment interactionHPA axispaternal parentingpolygenic plasticity

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Type
Regular Article
Information
Development and Psychopathology , Volume 35 , Issue 2 , May 2023 , pp. 524 - 536
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© The Author(s), 2022. Published by Cambridge University Press

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