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Developmental course of autistic social impairment in males


Recent research has suggested that autistic social impairment (ASI) is continuously distributed in nature and that subtle autistic-like social impairments aggregate in the family members of children with pervasive developmental disorders (PDDs). This study examined the longitudinal course of quantitatively characterized ASI in 3- to 18-year-old boys with and without PDD. We obtained assessments of 95 epidemiologically ascertained male–male twin pairs and a clinical sample of 95 affected children using the Social Responsiveness Scale (SRS), at two time points, spaced 1–5 years apart. Longitudinal course was examined as a function of age, familial loading for PDD, and autistic severity at baseline. Interindividual variation in SRS scores was highly preserved over time, with test–retest correlation of 0.90 for the entire sample. SRS scores exhibited modest general improvement over the study period; individual trajectories varied as a function of severity at baseline and were highly familial. Quantitative measurements of ASI reflect heritable traitlike characteristics. Such measurements can serve as reliable indices of phenotypic severity for genetic and neurobiologic studies, and have potential utility for ascertaining incremental response to intervention.

Corresponding author
Address correspondence and reprint requests to: John N. Constantino, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8134, St. Louis, MO 63110; E-mail:
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J. N. Constantino , C. P. Gruber , S. Davis , S. Hayes , N. Passanante , & T. Przybeck (2004). The factor structure of autistic traits. Journal of Child Psychology and Psychiatry, 45, 719726.

J. N. Constantino , J. J. Hudziak , & R. D. Todd (2003). Deficits in reciprocal social behavior in male twins: Evidence for a genetically independent domain of psychopathology. Journal of the American Academy of Child & Adolescent Psychiatry, 42, 458467.

J. N. Constantino , C. Lajonchere , M. Lutz , T. Gray , A. Abbacchi , K. McKenna , (2006). Autistic social impairment in the siblings of children with pervasive developmental disorders. American Journal of Psychiatry, 163, 294296.

J. N. Constantino , P. D. LaVesser , Y. Zhang , A. M. Abbacchi , T. Gray , & R.D. Todd (2007). Rapid quantitative assessment of autistic social impairment by classroom teachers. Journal of the American Academy of Child & Adolescent Psychiatry, 46, 16681676.

J. N. Constantino , T. Przybeck , D. Friesen , & R. D. Todd (2000). Reciprocal social behavior in children with and without pervasive developmental disorders. Developmental and Behavioral Pediatrics, 21, 211.

J. N. Constantino , & R. D. Todd (2000). Genetic structure of reciprocal social behavior. American Journal of Psychiatry, 157, 20432045.

J. N. Constantino , & R. D. Todd (2003). Autistic traits in the general population: A twin study. Archives of General Psychiatry, 60, 524530.

J. N. Constantino , & R. D. Todd (2005). Intergenerational transmission of subthreshold autistic traits in the general population. Biological Psychiatry, 57, 655660.

J. A. Duvall , A. Lu , R. M. Cantor , R. D. Todd , J. N. Constantino , & D. H. Geschwind (2007). A quantitative trait locus analysis of social responsiveness in multiplex autism families. American Journal of Psychiatry, 164, 656662.

L. C. Eaves , & H. H. Ho , (1996). Brief report: Stability and change in cognitive and behavioral characteristics of autism through childhood. Journal of Autism and Developmental Disorders, 26, 557569.

C. J. McDougle , L. Scahill , M. G. Aman , J. T. McCracken , E. Tierney , M. Davies , (2005). Risperidone for the core symptom domains of autism: Results from the study by the autism network of the research units on pediatric psychopharmacology. American Journal of Psychiatry, 162, 11421148.

C. McGovern , & M. Sigman (2005). Continuity and change from early childhood to adolescence in autism. Journal of Child Psychology and Psychiatry, 46, 401408.

G. B. Mesibov , E. Schopler , B. Schaffer , & N. Michal (1989). Use of the Childhood Autism Rating Scale (CARS) with autistic adolescents and adults. Journal of the American Academy of Child & Adolescent Psychiatry, 28, 538541.

M. C. Neale & L. R. Cardon (1992). Methodology for genetic studies of twins and families. Boston: Kluwer Academic.

J. Nurnberger , M. Blehar , C. Kaufman , C. York-Cooler , S. Simpson , J. Harkavy-Friedman , (1994). Diagnostic Interview for Genetic Studies. Rationale, unique features, and training NIMH Genetics Initiative. Archives of General Psychiatry, 51, 849859.

A. Pickles , E. Starr , S. Kazak , P. Bolton , K. Papanikolaou , A. Bailey , (2000). Variable expression of the autism broader phenotype: Findings from extended pedigrees. Journal of Child Psychology and Psychiatry, 41, 491502.

E. Pine , J. Luby , A. Abbacchi , & J. N. Constantino (2006). Quantitative assessment of autistic symptomatology in preschoolers. Autism: The International Journal of Research and Practice, 10, 344352.

J. Piven , J. Harper , P. Palmers , & S. Arndt (1996). Course of behavioral change in autism: A retrospective study of high IQ adolescents and adults. Journal of the American Academy of Child & Adolescent Psychiatry, 35, 523529.

A. Ronald , F. Happe , T. S. Price , S. Baron-Cohen , & R. Plomin (2006). Phenotypic and genetic overlap between autistic traits at the extremes of the general population. Journal of the American Academy of Child & Adolescent Psychiatry, 45, 12061214.

P. Szatmari , S. E. Bryson , M. H. Boyle , D. L. Streiner , & E. Duku (2003). Predictors of outcome among high functioning children with autism and Asperger syndrome. Journal of Child Psychology and Psychiatry, 44, 520528.

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Development and Psychopathology
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