This Special Issue of Development and Psychopathology is devoted to thepsychological and biological consequences of stress across the developmental course.Contributions in this Special Issue address topics that are central to elucidating the impact thatstress exerts on developmental outcomes. These issues are investigated through examining adiverse array of populations, including rodent and nonhuman primate samples, as well as cohortsof maltreated children and adolescents with and without posttraumatic stress disorder (PTSD),children who were adopted from Romanian orphanages at differing points during infancy, agingHolocaust survivors and their offspring, children with depressive disorder, adolescents withschizotypal personality disorder, and adults with bipolar and unipolar mood disorders.