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Parental responsiveness moderates the association between early-life stress and reduced telomere length

  • A. Asok (a1), K. Bernard (a1), T. L. Roth (a1), J. B. Rosen (a1) and M. Dozier (a1)...


Early-life stress, such as maltreatment, institutionalization, and exposure to violence, is associated with accelerated telomere shortening. Telomere shortening may thus represent a biomarker of early adversity. Previous studies have suggested that responsive parenting may protect children from the negative biological and behavioral consequences of early adversity. This study examined the role of parental responsiveness in buffering children from telomere shortening following experiences of early-life stress. We found that high-risk children had significantly shorter telomeres than low-risk children, controlling for household income, birth weight, gender, and minority status. Further, parental responsiveness moderated the association between risk and telomere length, with more responsive parenting associated with longer telomeres only among high-risk children. These findings suggest that responsive parenting may have protective benefits on telomere shortening for young children exposed to early-life stress. Therefore, this study has important implications for early parenting interventions.


Corresponding author

Address correspondence and reprint requests to: Arun Asok, University of Delaware, 105 The Green Room 108, Newark, DE 19716; E-mail address:


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Afifi, T. O., & Macmillan, H. L. (2011). Resilience following child maltreatment: A review of protective factors. Canadian Journal of Psychiatry, 56, 266272.
Benetos, A., Okuda, K., Lajemi, M., Kimura, M., Thomas, F., Skurnick, J., et al. (2001). Telomere length as an indicator of biological aging: The gender effect and relation with pulse pressure and pulse wave velocity. Hypertension, 37, 381385.
Bernard, K., Butzin-Dozier, Z., Rittenhouse, J., & Dozier, M. (2010). Cortisol production patterns in young children living with birth parents vs children placed in foster care following involvement of Child Protective Services. Archives of Pediatrics and Adolescent Medicine, 164, 438443.
Bernard, K., & Dozier, M. (2010). Examining infants' cortisol responses to laboratory tasks among children varying in attachment disorganization: Stress reactivity or return to baseline? Developmental Psychology, 46, 17711778.
Beyne-Rauzy, O., Prade-Houdellier, N., Demur, C., Recher, C., Ayel, J., Laurent, G., et al. (2005). Tumor necrosis factor-alpha inhibits hTERT gene expression in human myeloid normal and leukemic cells. Blood, 106, 32003205.
Blackburn, E. H. (2001). Switching and signaling at the telomere. Cell, 106, 661673.
Bruce, J., Fisher, P. A., Pears, K. C., & Levine, S. (2009). Morning cortisol levels in preschool-aged foster children: Differential effects of maltreatment type. Developmental Psychobiology, 51, 1423.
Bruce, J., Kroupina, M., Parker, S., & Gunnar, M. R. (2000). The relationships between cortisol patterns, growth retardation, and developmental delays in postinstitutionalized children. Paper presented at the International Conference on Infant Studies, Brighton, UK.
Carlson, M., & Earls, F. (1997). Psychological and neuroendocrinological sequelae of early social deprivation in institutionalized children in Romania. Annals of the New York Academy of Sciences, 807, 419428.
Cawthon, R. M. (2002). Telomere measurement by quantitative PCR. Nucleic Acids Research, 30, e47.
Cicchetti, D. (2010). Resilience under conditions of extreme stress: A multilevel perspective. World Psychiatry, 9, 145154.
Cicchetti, D., Rogosch, F., Toth, S. L., & Sturge-Apple, M. L. (2011). Normalizing the development of cortisol regulation in maltreated infants through preventive interventions. Development and Psychopathology, 23, 789800.
Cicchetti, D., & Toth, S. L. (2005). Child maltreatment. Annual Review of Clinical Psychology, 1, 409438.
Danese, A., Pariante, C. M., Caspi, A., Taylor, A., & Poulton, R. (2007). Childhood maltreatment predicts adult inflammation in a life-course study. Proceedings of the National Academy of Sciences, 104, 13191324.
Dozier, M., Manni, M., Gordon, M. K., Peloso, E., Gunnar, M. R., Stovall-McClough, K. C., et al. (2006). Foster children's diurnal production of cortisol: An exploratory study. Child Maltreatment, 11, 189197.
Drury, S. S., Theall, K., Gleason, M. M., Smyke, A. T., De Vivo, I., Wong, J. Y., et al. (2012). Telomere length and early severe social deprivation: Linking early adversity and cellular aging. Molecular Psychiatry, 17, 719727.
Edwards, V. J., Holden, G. W., Felitti, V. J., & Anda, R. F. (2003). Relationship between multiple forms of childhood maltreatment and adult mental health in community respondents: Results from the adverse childhood experiences study. American Journal of Psychiatry, 160, 14531460.
Evans, G. W., Kim, P., Ting, A. H., Tesher, H. B., & Shannis, D. (2007). Cumulative risk, maternal responsiveness, and allostatic load among young adolescents. Developmental Psychology, 43, 341351.
Feldman, R. (2007). Parent–infant synchrony and the construction of shared timing: Physiological precursors, developmental outcomes, and risk conditions. Journal of Child Psychology and Psychiatry, 48, 329354.
Fisher, P. A., Gunnar, M. R., Dozier, M., Bruce, J., & Pears, K. C. (2006). Effects of therapeutic interventions for foster children on behavioral problems, caregiver attachment, and stress regulatory neural systems. Annals of New York Academy of Science, 1094, 215225.
Fisher, P. A., Stoolmiller, M., Gunnar, M. R., & Burraston, B. O. (2007). Effects of a therapeutic intervention for foster preschoolers on diurnal cortisol activity. Psychoneuroendocrinolgy, 32, 892905.
Floyd, R. A., Hensley, K., Jaffery, F., Maidt, L., Robinson, K., Pye, Q., et al. (1999). Increased oxidative stress brought on by pro-inflammatory cytokines in neurodegenerative processes and the protective role of nitrone-based free radical traps. Life Sciences, 65, 18931899.
Frenck, R. W. Jr., Blackburn, E. H., & Shannon, K. M. (1998). The rate of telomere sequence loss in human leukocytes varies with age. Proceedings of the National Academy of Sciences, 95, 56075610.
Gunnar, M. R., & Cheatham, C. L. (2003). Brain and behavior interface: Stress and the developing brain. Infant Mental Health Journal, 24, 195211.
Gunnar, M. R., & Donzella, B. (2002). Social regulation of the cortisol levels in early human development. Psychoneuroendocrinology, 27, 199220.
Gunnar, M. R., Fisher, P. A., & the Early Experience, Stress, and Prevention Network. (2006). Bringing basic research on early experience and stress neurobiology to bear on preventive interventions for neglected and maltreated children. Developmental Psychopathology, 18, 651677.
Gunnar, M. R., & Quevedo, K. (2007). The neurobiology of stress and development. Annual Review of Psychology, 58, 145173.
Gunnar, M. R., Talge, N. M., & Herrera, A. (2009). Stressor paradigms in developmental studies: What does and does not work to produce mean increases in salivary cortisol. Psychoneuroendocrinology, 34, 953967.
Harley, C. B. (1990). Aging of cultured human skin fibroblasts. Methods for Molecular Biology, 5, 2532.
Hayflick, L., & Moorhead, P. S. (1961). The serial cultivation of human diploid cell strains. Experimental Cell Research, 25, 585621.
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008). The link between childhood trauma and depression: Insights from HPA axis studies in humans. Psychoneuroendocrinology, 33, 693710.
Heim, C., Shugart, M., Craighead, W. E., & Nemeroff, C. B. (2010). Neurobiological and psychiatric consequences of child abuse and neglect. Developmental Psychobiology, 52, 671690.
Hertsgaard, L., Gunnar, M., Erickson, M. F., & Nachmias, M. (1995). Adrenocortical responses to the strange situation in infants with disorganized/disoriented attachment relationships. Child Development, 66, 11001106.
Hewakapuge, S., van Oorschot, R. A., Lewandowski, P., & Baindur-Hudson, S. (2008). Investigation of telomere lengths measurement by quantitative real-time PCR to predict age. Legal Medicine (Tokyo), 10, 236242.
Houben, J. M., Moonen, H. J., van Schooten, F. J., & Hageman, G. J. (2008). Telomere length assessment: Biomarker of chronic oxidative stress? Free Radical Biology and Medicine, 44, 235246.
Juster, R. P., McEwen, B. S., & Lupien, S. J. (2010). Allostatic load biomarkers of chronic stress and impact on health and cognition. Neuroscience and Biobehavioral Reviews, 35, 216.
Kananen, L., Surakka, I., Pirkola, S., Suvisaari, J., Lonnqvist, J., Peltonen, L., et al. (2010). Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls. PLoS One, 5, e10826.
Kiecolt-Glaser, J. K., Gouin, J. P., Weng, N. P., Malarkey, W. B., Beversdorf, D. Q., & Glaser, R. (2011). Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation. Psychosomatic Medicine, 73, 1622.
Larson, M. C., White, B. P., Cochran, A., Donzella, B., & Gunnar, M. (1998). Dampening of the cortisol response to handling at 3 months in human infants and its relation to sleep, circadian cortisol activity, and behavioral distress. Developmental Psychobiology, 33, 327337.
Laucht, M., Esser, G., & Schmidt, M. H. (2001). Differential development of infants at risk for psychopathology: The moderating role of early maternal responsivity. Developmental Medicine and Child Neurology, 43, 292300.
Masten, A., Best, K., & Garmezy, N. (1990). Resilience and development: Contributions from the study of children who overcome adversity. Development and Psychopathology, 2, 425444.
McCrory, E., De Brito, S. A., & Viding, E. (2010). Research review: The neurobiology and genetics of maltreatment and adversity. Journal of Child Psychology and Psychiatry, 51, 10791095.
McEachern, M. J., Krauskopf, A., & Blackburn, E. H. (2000). Telomeres and their control. Annual Review of Genetics, 34, 331358.
McEwen, B. S. (1998). Protective and damaging effects of stress mediators. New England Journal of Medicine, 338, 171179.
McEwen, B. S. (2000). Allostasis and allostatic load: Implications for neuropsychopharmacology. Neuropsychopharmacology, 22, 108124.
McEwen, B. S. (2008). Understanding the potency of stressful early life experiences on brain and body function. Metabolism, 57(Suppl. 2), S11S15.
Melchior, M., Moffitt, T. E., Milne, B. J., Poulton, R., & Caspi, A. (2007). Why do children from socioeconomically disadvantaged families suffer from poor health when they reach adulthood? A life-course study. American Journal of Epidemiology, 166, 966974.
Moriceau, S., Roth, T. L., & Sullivan, R. M. (2010). Rodent model of infant attachment learning and stress. Developmental Psychobiology, 52, 651660.
National Institute of Child Health and Human Development Early Child Care Research Network. (1999). Child care and mother–child interaction in the first 3 years of life. Developmental Psychology, 35, 13991413.
National Institute of Child Health and Human Development Early Child Care Research Network. (2003). Early child care and mother–child interaction from 36 months through first grade. Infant Behavior and Development, 26, 345370.
Neigh, G. N., Gillespie, C. F., & Nemeroff, C. B. (2009). The neurobiological toll of child abuse and neglect. Trauma, Violence, and Abuse, 10, 389410.
O'Callaghan, N. J., & Fenech, M. (2011). A quantitative PCR method for measuring absolute telomere length. Biological Procedures Online, 13, 3.
O'Donovan, A., Tomiyama, A. J., Lin, J., Puterman, E., Adler, N. E., Kemeny, M., et al. (2012). Stress appraisals and cellular aging: A key role for anticipatory threat in the relationship between psychological stress and telomere length. Brain, Behavior, and Immunity, 26, 573579.
Petersen, S., Saretzki, G., & von Zglinicki, T. (1998). Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Experimental Cell Research, 239, 152160.
Price, L. H., Kao, H. T., Burgers, D. E., Carpenter, L. L., & Tyrka, A. R. (2013). Telomeres and early-life stress: An overview. Biological Psychiatry, 73, 1523.
Raver, C. C. (1996). Relations between social contingency in mother–child interaction and 2-year-olds' social competence. Developmental Psychology, 32, 850859.
Rocissano, L., Lynch, V., & Slade, A. (1987). Dyadic synchrony and toddler compliance. Developmental Psychology, 23, 698704.
Sapolsky, R. M., & Meaney, M. J. (1986). Maturation of the adrenocortical stress response: Neuroendocrine control mechanisms and the stress hyporesponsive period. Brain Research, 396, 6476.
Shalev, I. (2012). Early life stress and telomere length: Investigating the connection and possible mechanisms: A critical survey of the evidence base, research methodology and basic biology. Bioessays, 34, 943952.
Shalev, I., Moffitt, T. E., Sugden, K., Williams, B., Houts, R. M., Danese, A., et al. (2012). Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: A longitudinal study. Molecular Psychiatry. Advance online publication. doi:10.1038/mp.2012.32 mp201232
Shonkoff, J. P., & Bales, S. N. (2011). Science does not speak for itself: Translating child development research for the public and its policymakers. Child Development, 82, 1732.
Spangler, G., & Grossmann, K. E. (1993). Biobehavioral organization in securely and insecurely attached infants. Child Development, 64, 14391450.
Surtees, P. G., Wainwright, N. W., Pooley, K. A., Luben, R. N., Khaw, K. T., Easton, D. F., et al. (2011). Life stress, emotional health, and mean telomere length in the European Prospective Investigation into Cancer (EPIC)–Norfolk population study. Journals of Gerontology, 66A, 11521162.
Tomiyama, A. J., O'Donovan, A., Lin, J., Puterman, E., Lazaro, A., Chan, J., et al. (2012). Does cellular aging relate to patterns of allostasis? An examination of basal and stress reactive HPA axis activity and telomere length. Physiology & Behavior, 106, 4045.
Tyrka, A. R., Price, L. H., Kao, H. T., Porton, B., Marsella, S. A., & Carpenter, L. L. (2010). Childhood maltreatment and telomere shortening: Preliminary support for an effect of early stress on cellular aging. Biological Psychiatry, 67, 531534.
von Zglinicki, T. (2002). Oxidative stress shortens telomeres. Trends in Biochemical Sciences, 27, 339344.
Winberg, J. (2005). Mother and newborn baby: Mutual regulation of physiology and behavior—A selective review. Developmental Psychobiology, 47, 217229.
You, J. M., Yun, S. J., Nam, K. N., Kang, C., Won, R., & Lee, E. H. (2009). Mechanism of glucocorticoid-induced oxidative stress in rat hippocampal slice cultures. Canadian Journal of Physiology and Pharmacology, 87, 440447.
Zeichner, S. L., Palumbo, P., Feng, Y., Xiao, X., Gee, D., Sleasman, J., et al. (1999). Rapid telomere shortening in children. Blood, 93, 28242830.
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