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Paying attention to reading: The neurobiology of reading and dyslexia

  • Sally E. Shaywitz (a1) and Bennett A. Shaywitz (a1)


Extraordinary progress in functional brain imaging, primarily advances in functional magnetic resonance imaging, now allows scientists to understand the neural systems serving reading and how these systems differ in dyslexic readers. Scientists now speak of the neural signature of dyslexia, a singular achievement that for the first time has made what was previously a hidden disability, now visible. Paralleling this achievement in understanding the neurobiology of dyslexia, progress in the identification and treatment of dyslexia now offers the hope of identifying children at risk for dyslexia at a very young age and providing evidence-based, effective interventions. Despite these advances, for many dyslexic readers, becoming a skilled, automatic reader remains elusive, in great part because though children with dyslexia can be taught to decode words, teaching children to read fluently and automatically represents the next frontier in research on dyslexia. We suggest that to break through this “fluency” barrier, investigators will need to reexamine the more than 20-year-old central dogma in reading research: the generation of the phonological code from print is modular, that is, automatic and not attention demanding, and not requiring any other cognitive process. Recent findings now present a competing view: other cognitive processes are involved in reading, particularly attentional mechanisms, and that disruption of these attentional mechanisms play a causal role in reading difficulties. Recognition of the role of attentional mechanisms in reading now offer potentially new strategies for interventions in dyslexia. In particular, the use of pharmacotherapeutic agents affecting attentional mechanisms not only may provide a window into the neurochemical mechanisms underlying dyslexia but also may offer a potential adjunct treatment for teaching dyslexic readers to read fluently and automatically. Preliminary studies suggest that agents traditionally used to treat disorders of attention, particularly attention-deficit/hyperactivity disorder, may prove to be an effective adjunct to improving reading in dyslexic students.


Corresponding author

Address correspondence and reprint requests to: Sally Shaywitz, Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510; E-mail:


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This work was supported by grants from the National Institute of Child Health and Human Development (P50 HD25802, RO1 HD046171, R01 HD057655).



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Anderson, A., & Gore, J. (1997). The physical basis of neuroimaging techniques. In Lewis, M. & Peterson, B. (Eds.), Child and adolescent psychiatric clinics of North America (Vol. 6, pp. 213264). Philadelphia, PA: W.B. Saunders.
Arnsten, A. (2006a). Fundamentals of attention-deficit/hyperactivity disorder: Circuits and pathways. Journal of Clinical Psychiatry, 67(Suppl. 8), 712.
Arnsten, A. F. T. (2006b). Stimulants: Therapeutic actions in ADHD. Neuropsychopharmacology, 18.
Aron, A. R., Dowson, J. H., Sahakian, B. J., & Robbins, T. W. (2003). Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder. Biological Psychiatry, 54, 14651468.
August, G. J., & Garfinkel, B. D. (1990). Comorbidity of ADHD and reading disability among clinic-referred children. Journal of Abnormal Child Psychology, 18, 2945.
Aylward, E., Richards, T., Berninger, V., Nagy, W., Field, K., Grimme, A., et al. (2003). Instructional treatment associated with changes in brain activation in children with dyslexia. Neurology, 61, 212219.
Bedard, A.-C., Jain, U., Johnson, S. H., & Tannock, R. (2007). Effects of methylphenidate on working memory components: Influence of measurement. Journal of Child Psychology and Psychiatry and Allied Disciplines, 48, 872880.
Ben-Shachar, M., Dougherty, R. F., Deutsch, G. K., & Wandell, B. A. (2007). Differential sensitivity to words and shapes in ventral occipito-temporal cortex. Cerebral Cortex, 17, 16041611.
Binder, J., & Mohr, J. (1992). The topography of callosal reading pathways. Brain, 115, 18071826.
Birnbaum, S. G., Gobeske, K. T., Auerbach, J., Taylor, J., & Arnsten, A. F. T. (1999). A role for norepinephrine in stress-induced cognitive deficits: Alpha 1-adrenoceptor mediation in prefrontal cortex. Biological Psychiatry, 46, 12661274.
Birnbaum, S. G., Yuan, P. X., Wang, M., Vijayraghavan, S., Bloom, A. K., Davis, D. J., et al. (2004). Protein kinase C overactivity impairs prefrontal cortical regulation of working memory. Science, 306, 882884.
Bloomfield, L. (1933). Language. New York: Holt, Rinehart and Winston.
Booth, J. R., Bebko, G., Burman, D. D., & Bitan, T. (2007). Children with reading disorder show modality independent brain abnormalities during semantic tasks. Neuropsychologia, 45, 775783.
Booth, J. R., Burman, D. D., Meyer, J. R., Gitelman, D. R., Parrish, T. B., & Mesulam, M. M. (2002). Functional anatomy of intra- and cross-modal lexical tasks. NeuroImage, 16, 722.
Booth, J. R., Burman, D. D., Meyer, J. R., Gitelman, D. R., Parrish, T. B., & Mesulam, M. M. (2003). Relation between brain activation and lexical performance. Human Brain Mapping, 19, 155169.
Brambati, S., Termine, C., Ruffino, M., Danna, M., Lanzi, G., Stella, G., et al. (2006). Neuropsychological deficits and neural dysfunction in familial dyslexia. Brain Research, 1113, 174185.
Brambati, S. M., Termine, C., Ruffino, M., Stella, G., Fazio, F., Cappa, S. F., et al. (2004). Regional reductions of gray matter volume in familial dyslexia. Neurology, 63, 742745.
Brozoski, T., Brown, R., Rosvold, H., & Goldman, P. (1979). Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science, 205, 929931.
Bruck, M. (1992). Persistence of dyslexics' phonological awareness deficits. Developmental Psychology, 28, 874886.
Bruck, M. (1998). Outcomes of adults with childhood histories of dyslexia. In Hulme, C. & Joshi, R. (Eds.), Cognitive and linguistic bases of reading, writing, and spelling (pp. 179200). Mahwah, NJ: Erlbaum.
Bush, G., Frazier, J. A., Rauch, S. L., Seidman, L. J., Whalen, P. J., Jenike, M. A., et al. (1999). Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the counting Stroop. Biological Psychiatry, 45, 15421552.
Bush, G., Valera, E., & Seidman, L. (2005). Functional neuroimaging of attention-deficit/hyperactivity disorder: A review and suggested future directions. Biological Psychiatry, 57, 12731284.
Bymaster, F., Katner, B., Nelson, D., Hemrick-Luecke, S., Threlkeld, P., Heiligenstein, J., et al. (2002). Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: A potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology, 27, 699711.
Cao, F., Bitan, T., Chou, T.-L., Burman, D. D., & Booth, J. R. (2006). Deficient orthographic and phonological representations in children with dyslexia revealed by brain activation patterns. Journal of Child Psychology and Psychiatry and Allied Disciplines, 47, 10411050.
Casey, B., Nigg, J., & Durston, S. (2007). New potential leads in the biology and treatment of attention deficit-hyperactivity disorder. Current Opinion in Neurology, 20, 119124.
Casey, B. J., Epstein, J. N., Buhle, J., Liston, C., Davidson, M. C., Tonev, S. T., et al. (2007). Frontostriatal connectivity and its role in cognitive control in parent–child dyads with ADHD. American Journal of Psychiatry, 164, 17291736.
Cohen, L., Dehaene, S., Naccache, L., Lehericy, S., Dehaene-Lambertz, G., Henaff, M. A., et al. (2000). The visual word form area: Spatial and temporal characterization of an initial stage of reading in normal subjects and posterior split-brain patients. Brain, 123(Pt. 2), 291307.
Cohen, L., Lehericy, S., Henry, C., Bourgeois, M., Larroque, C., Sainte-Rose, C., et al. (2004). Learning to read without a left occipital lobe: Right-hemispheric shift of visual word form area. Annals of Neurology, 56, 890894.
Cohen, L., Martinaud, O., Lemer, C., Lehericy, S., Samson, Y., Obadia, M., et al. (2003). Visual word recognition in the left and right hemispheres: Anatomical and functional correlates of peripheral alexias. Cerebral Cortex, 13, 13131333.
Coltheart, M. (1978). Lexical access in simple reading tasks. In Underwood, G. (Ed.) Strategies of information processing (pp. 151216). London: Academic Press.
Coltheart, M. (1985). Cognitive neuropsychology and the study of reading. In Posner, M. & Marin, O. (Eds.), Attention and performance X1 (pp. 337). Hillsdale, NJ: Erlbaum.
Coltheart, M., Curtis, B., Atkins, P., & Haller, M. (1993). Models of reading aloud: Dual-route and parallel-distributed-processing approaches. Psychological Review, 100, 589608.
Coltheart, M., & Rastle, K. (1994). Serial processing in reading aloud: Evidence for dual-route models of reading. Journal of Experimental Psychology: Human Perception and Performance, 20, 11971211.
Coltheart, M., Rastle, K., Perry, C., Langdon, R., & Ziegler, J. (2001). DRC: A dual route cascaded model of visual word recognition and reading aloud. Psychological Review, 108, 204256.
Damasio, A. R., & Damasio, H. (1983). The anatomic basis of pure alexia. Neurology, 33, 15731583.
Dehaene, S., Cohen, L., Sigman, M., & Vinckier, F. (2005). The neural code for written words: A proposal. Trends in Cognitive Sciences, 9, 335341.
Dehaene, S., Naccache, L., Cohen, L., Le Bihan, D., Mangin, J., Poline, J., et al. (2001). Cerebral mechanisms of word masking and unconscious repetition priming. Nature Neuroscience, 4, 752758.
Dejerine, J. (1891). Sur un cas de cécité verbale avec agraphie, suivi d'autopsie. Compte Rendu des Seances Société du Biologie, 43, 197201.
Dejerine, J. (1892). Contribution a l'etude anatomo-pathologique et clinique des differentes varietes de cecite verbale. Memoires de la Societe de Biologie, 4, 6190.
Devlin, J., Jamison, H., Gonnerman, L., & Matthews, P. (2006). The role of the posterior fusiform gyrus in reading. Journal of Cognitive Neuroscience, 18, 911922.
Durston, S., Davidson, M. C., Mulder, M. J., Spicer, J. A., Galvan, A., Tottenham, N., et al. (2007). Neural and behavioral correlates of expectancy violations in attention-deficit hyperactivity disorder. Journal of Child Psychology and Psychiatry, 48, 881889.
Dykman, R. A., & Ackerman, P. T. (1991). Attention deficit disorder and specific reading disability: Separate but often overlapping disorders. Journal of Learning Disabilities, 24, 96103.
Eden, G., Jones, K., Cappell, K., Gareau, L., Wood, F., Zeffiro, T., et al. (2004). Neural changes following remediation in adult developmental dyslexia. Neuron, 44, 411422.
Elliott, R., Sahakian, B., Matthews, K., Bannerjea, A., Rimmer, J., & Robbins, T. (1997). Effects of methylphenidate on spatial working memory and planning in healthy young adults. Psychopharmacology, 131, 196206.
Epstein, J. N., Casey, B. J., Tonev, S. T., Davidson, M. C., Reiss, A. L., Garrett, A., et al. (2007). ADHD- and medication-related brain activation effects in concordantly affected parent–child dyads with ADHD. Journal of Child Psychology and Psychiatry, 48, 899913.
Ferrer, E., McArdle, J., Shaywitz, B., Holahan, J., Marchione, K., & Shaywitz, S. (2007). Longitudinal models of developmental dynamics between reading and cognition from childhood to adolescence. Developmental Psychology, 43, 14601473.
Fiebach, C. J., Friederici, A. D., Muller, K., & Cramon, D. Y. V. (2002). fMRI evidence for dual routes to the mental lexicon in visual word recognition. Journal of Cognitive Neuroscience, 14, 1123.
Fiez, J. A., & Peterson, S. E. (1998). Neuroimaging studies of word reading. Proceedings of the National Academy of Science of the United States of America, 95, 914921.
Fletcher, P., Frith, C., & Rugg, M. (1997). The functional anatomy of episodic memory. Trends in Neuroscience, 20, 213218.
Fodor, J. A. (1983). The modularity of mind. Cambridge, MA: MIT Press.
Forster, K. I., & Chambers, S. M. (1973). Lexical access and naming time. Journal of Verbal Learning and Verbal Behavior, 12, 627635.
Frackowiak, R., Friston, K., Frith, C., Dolan, R., Price, C., Zeki, S., et al. (2004). Human Brain Function (2nd ed.). San Diego, CA: Academic Press/Elsevier Science.
Francis, D. J., Shaywitz, S. E., Stuebing, K. K., Shaywitz, B. A., & Fletcher, J. M. (1996). Developmental lag versus deficit models of reading disability: A longitudinal, individual growth curves analysis. Journal of Educational Psychology, 88, 317.
Friedman, R. F., Ween, J. E., & Albert, M. L. (1993). Alexia. In Heilman, K. M. & Valenstein, E. (Eds.), Clinical neuropsychology (3rd ed., pp. 3762). New York: Oxford University Press.
Frith, U., & Snowling, M. (1983). Reading for meaning and reading for sound in autistic and dyslexic children. British Journal of Developmental Psychology, 1, 329342.
Gaillard, R., Naccache, L., Pinel, P., Clemenceau, S., Volle, E., Hasboun, D., et al. (2006). Direct intracranial, FMRI, and lesion evidence for the causal role of left inferotemporal cortex in reading. Neuron, 50, 191204.
Gaillard, W. D., Balsamo, L. M., Ibrahim, Z., Sachs, B. C., & Xu, B. (2003). fMRI identifies regional specialization of neural networks for reading in young children. Neurology, 60, 94100.
Galaburda, A. M., Menard, M., & Rosen, G. D. (1994). Evidence for aberrant auditory anatomy in developmental dyslexia. Proceedings of the National Academy of Sciences of the United States of America, 91, 80108013.
Geschwind, N. (1965). Disconnection syndromes in animals and man. Brain, 88, 237294.
Grigg, W., Donahue, P., & Dion, G. (2007). The Nation's Report Card: 12th-grade reading and mathematics 2005 (NCES Report 2007-468). Washington, DC: US Government Printing Office.
Grizenko, N., Bhat, M., Schwartz, G., Ter-Sttepanian, M., & Joober, R. (2006). Efficacy of methylphenidate in children with attention-deficit hyperactivity disorder and learning disabilitites: A randomized crossover trial. Journal of Psychiatry & Neuroscience, 31, 4651.
Gronau, N., & Frost, R. (1997). Prelexical phonologic computation in a deep orthography: Evidence from backward masking in Hebrew. Psychonomic Bulletin & Review, 4, 107112.
Harris, M., & Coltheart, M. (1986). Language processing in children and adults: An introduction. London: Routledge & Kegan Paul.
Hart, B. H., & Risley, T. R. (1995). Meaningful differences in the everyday experience of young American children. Baltimore, MD: Paul H. Brookes.
Helenius, P., Tarkiainen, A., Cornelissen, P., Hansen, P. C., & Salmelin, R. (1999). Dissociation of normal feature analysis and deficient processing of letter-strings in dyslexic adults. Cerebral Cortex, 4, 476483.
Henry, C., Gaillard, R., Volle, E., Chiras, J., Ferrieux, S., Dehaene, S., et al. (2005). Brain activations during letter-by-letter reading: A follow-up study. Neuropsychologia, 43, 19831989.
Horwitz, B., Rumsey, J. M., & Donohue, B. C. (1998). Functional connectivity of the angular gyrus in normal reading and dyslexia. Proceedings of the National Academy of Science of the United States of America, 95, 89398944.
Huey, E. (1908). The psychology and pedagogy of reading. New York: Macmillan.
Hulme, C., Snowling, M., Caravolas, M., & Carroll, J. (2005). Phonological skills are (probably) one cause of success in learning to read: A comment on Castles and Coltheart. Scientific Studies of Reading, 9, 351365.
Jezzard, P., Matthews, P., & Smith, S. (2001). Functional MRI, an introduction to methods. Oxford: Oxford University Press.
Johnson, R. L., & Rayner, K. (2007). Top-down and bottom-up effects in pure alexia: Evidence from eye movements. Neuropsychologia, 45, 22462257.
Johnston, M., & Castles, A. (2003). Dissociating automatic orthographic and phonological codes in lexical access and lexical acquisition. In Kinoshita, S. & Lupker, S. (Eds.), Masked priming: The state of the art (pp. 193222). Hove: Psychology Press.
Keulers, E. H. H., Hendriksen, J. G. M., Feron, F. J. M., Wassenberg, R., Wuisman-Frerker, M. G. F., Jolles, J., et al. (2007). Methylphenidate improves reading performance in children with attention deficit hyperactivity disorder and comorbid dyslexia: An unblinded clinical trial. European Journal of Paediatric Neurology, 11, 2128.
Kronbichler, M., Hutzler, F., Staffen, W., Mair, A., Ladurner, G., & Wimmer, H. (2006). Evidence for a dysfunction of left posterior reading areas in German dyslexic readers. Neuropsychologia, 44, 18221832.
LaBerge, D., & Samuels, S. J. (1974). Toward a theory of automatic information processing in reading. Cognitive Psychology, 6, 293323.
Lawler, A. (2001). Archaeology. Writing gets a rewrite. Science, 292, 24182420.
Leff, A., Spitsyna, G., Plant, G., & Wise, R. (2006). Structural anatomy of pure and hemianopic alexia. Journal of Neurology, Neurosurgery and Psychiatry, 77, 10041007.
Lefly, D. L., & Pennington, B. F. (1991). Spelling errors and reading fluency in compensated adult dyslexics. Annals of Dyslexia, 41, 143162.
Lerner, J. (1989). Educational interventions in learning disabilities. Journal of the American Academy of Child & Adolescent Psychiatry, 28, 326331.
Liberman, A., Cooper, F., Shankweiler, D., & Studdert-Kennedy, M. (1967). Perception of the speech code. Psychological Review, 74, 431461.
Liberman, I. Y., Shankweiler, D., & Liberman, A. M. (1989). Phonology and reading disability: Solving the reading puzzle. In Shankweiler, D. & Liberman, I. Y. (Eds.), International Academy for Research in Learning Disabilities monograph series (Vol. 6, pp. 133). Ann Arbor, MI: University of Michigan Press.
Livingstone, M. S., Rosen, G. D., Drislane, F. W., & Galaburda, A. M. (1991). Physiological and anatomical evidence for a magnocellular defect in developmental dyslexia. Proceedings of the National Academy of Sciences of the United States of America, 88, 79437947.
Logan, G. (1988a). Toward an instance theory of automatization. Psychological Review, 95, 492527.
Logan, G. (1988b). Automaticity, resources and memory: Theoretical controversies and practical implications. Human Factors, 30, 538598.
Logan, G. (1990). Repetition priming and automaticity: Common underlying mechanisms? Cognitive Psychology, 22, 135.
Logan, G. (1991). Automaticity and memory. In Hockley, W. & Lewandowsky, S. (Eds.), Relating theory and data: Essays on human memory in honor of Bennet B. Murdock. Hillsdale, NJ: Erlbaum.
Logan, G. (1992). Shapes of reaction-time distributions and shapes of learning curves: A test of the instance theory of automaticity. Journal of Experimental Psychology: Learning, Memory and Cognition, 18, 883914.
Logan, G. (1997). Automaticity and reading: Perspectives from the instance theory of automatization. Reading and Writing Quarterly: Overcoming Learning Disabilities, 13, 123146.
Logan, G., & Etherton, J. (1998). What is learned during automatization? II. Obligatory encoding of location information. Journal of Experimental Psychology: Human Perception and Performance, 24, 17201736.
Logan, G., Taylor, S., & Etherton, J. (1996). Attention in the acquisition and expression of automaticity. Journal of Experimental Psychology: Learning, Memory, and Cognition, 22, 620638.
Logan, G., Taylor, S., & Etherton, J. (1999). Attention and automaticity: Toward a theoretical integration. Psychological Research, 62, 165181.
Logan, G. D. (2002). An instance theory of attention and memory. Psychological Review, 109, 376400.
Lovegrove, W. J., Bowling, A., Badcock, D., & Blackwood, M. (1980). Specific reading disability: Differences in contrast sensitivity as a function of spatial frequency. Science, 210, 439440.
Lovett, M., Ransby, M., Hardwick, N., Johns, M., & Donaldson, S. (1989). Can dyslexia be treated? Treatment-specific and generalized treatment effects in dyslexic children's response to remediation. Brain and Language, 37, 90121.
Lukatela, G., & Turvey, M. (1994a). Visual lexical access is initially phonological: I. Evidence from associative priming by words, homophones, and pseudohomophones. Journal of Experimental Psychology: General, 123, 331353.
Lukatela, G., & Turvey, M. (1994b). Visual lexical access is initially phonological: 2. Evidence from phonological priming by homophones and pseudohomophones. Journal of Experimental Psychology: General, 123, 331353.
Luo, C., Johnson, R., & Gallo, D. (1998). Automatic activation of phonological information in reading: Evidence from the semantic relatedness decision task. Memory & Cognition, 26, 833843.
Lyon, G. (1995). Toward a definition of dyslexia. Annals of Dyslexia, 45, 327.
Lyon, G. R., Shaywitz, S. E., & Shaywitz, B. A. (2003). A definition of dyslexia. Annals of Dyslexia., 53, 114.
MacLeod, A., Buckner, R., Miezin, F., Petersen, S., & Raichle, M. (1998). Right anterior prefrontal cortex activation during semantic monitoring and working memory. NeuroImage, 7, 4148.
Marshall, J. C., & Newcombe, F. (1973). Patterns of paralexia: A psycholinguistic approach. Journal of Psycholinguistic Research, 2, 175199.
McCandliss, B., Cohen, L., & Dehaene, S. (2003). The visual word form area: Expertise in reading in the fusiform gyrus. Trends in Cognitive Sciences, 7, 293299.
McCrory, E., Mechelli, A., Frith, U., & Price, C. (2005). More than words: A common neural basis for reading and naming deficits in developmental dyslexia? Brain, 128, 261267.
McInnes, A., Bedard, A.-C., Hogg-Johnson, S., & Tannock, R. (2007). Preliminary evidence of beneficial effects of methylphenidate on listening comprehension in children with attention-deficit/hyperactivity disorder. Journal of Child and Adolescent Psychopharmacology, 17, 3549.
McIntosh, A., Bookstein, F., Haxby, J., & Grady, C. (1996). Spatial pattern analysis of functional brain images using partial least squares. NeuroImage, 3, 143157.
McIntosh, A., Nyberg, L., Bookstein, F., & Tulving, E. (1997). Differential functional connectivity of prefrontal and medial temporal cortices during episodic memory retrieval. Human Brain Mapping, 5, 323327.
Mehta, M. A., Goodyer, I., & Sahakian, B. J. (2004). Methylphenidate improves working memory and set-shifting in AD/HD: Relationships to baseline memory capacity. Journal of Child Psychology and Psychiatry, 45, 293305.
Mehta, M. A., Owen, A. M., Sahakian, B. J., Mavaddat, N., Pickard, J. D., & Robbins, T. W. (2000). Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain. Journal of Neuroscience, 20, 65.
Morgan, W. P. (1896). A case of congenital word blindness. British Medical Journal, 1378.
Nakamura, K., Dehaene, S., Jobert, A., Le Bihan, D., & Kouider, S. (2005). Subliminal convergence of Kanji and Kana words: Further evidence for functional parcellation of the posterior temporal cortex in visual word perception. Journal of Cognitive Neuroscience, 17, 954968.
Nakamura, K., Dehaene, S., Jobert, A., Le Bihan, D., & Kouider, S. (2007). Task-specific change of unconscious neural priming in the cerebral language network. Proceedings of the National Academy of Sciences of the United States of America, 104, 1964319648.
Nakamura, K., Hara, N., Kouider, S., Takayama, Y., Hanajima, R., Sakai, K., et al. (2006). Task-guided selection of the dual neural pathways for reading. Neuron, 52, 557564.
Nation, K., & Snowling, M. (1997). Individual differences in contextual facilitation: Evidence from dyslexia and poor reading comprehension. Unpublished manuscript.
National Reading Panel. (2000). Teaching children to read: An evidence based assessment of the scientific research literature on reading and its implications for reading instruction (NIH Publication No. 00-4754). Washington, DC: US Department of Health and Human Services.
Nicolson, R. I., & Fawcett, A. J. (1990). Automaticity: A new framework for dyslexia research? Cognition, 35, 159182.
Nicolson, R. I., Fawcett, A. J., & Dean, P. (2001). Developmental dyslexia: The cerebellar deficit hypothesis. Trends in Neurosciences, 24, 508511.
Park, L., Nigg, J., Waldman, I., Nummy, K., Huang-Pollock, C., Rappley, M., et al. (2005). Association and linkage of alpha-2A adrenergic receptor gene polymorphisms with childhood ADHD. Molecular Psychiatry, 10, 572580.
Paulesu, E., Demonet, J.-F., Fazio, F., McCrory, E., Chanoine, V., Brunswick, N., et al. (2001). Dyslexia-cultural diversity and biological unity. Science, 291, 21652167.
Perfetti, C., Bell, L., & Delaney, S. (1988). Automatic phonetic activation in silent word reading: Evidence from backward masking. Journal of Memory and Language, 27, 5870.
Perie, M., Grigg, W., & Donahue, P. (2005). National assessment of educational progress: The nation's report card, Reading 2005 (NPN Report No. 2006-451). Washington, DC: US Government Printing Office.
Price, C., Moore, C., & Frackowiak, R. S. J. (1996). The effect of varying stimulus rate and duration on brain activity during reading. NeuroImage, 3, 4052.
Price, C. J., & Devlin, J. T. (2003). The myth of the visual word form area. NeuroImage, 19, 473481.
Price, C. J., & Devlin, J. T. (2004). The pro and cons of labelling a left occipitotemporal region: “The visual word form area.” NeuroImage, 22, 477479.
Ramos, B., & Arnsten, A. (2007). Adrendergic pharmacology and cognition: Focus on the prefrontal cortex. Pharmacology & Therapeutics, 113, 523536.
Ramus, F., Rosen, S., Dakin, S., Day, B., Castellote, J., White, S., et al. (2003). Theories of developmental dyslexia: Insights from a multiple case study of dyslexic adults. Brain, 126, 841865.
Rastle, K., & Coltheart, M. (1998). Whammy and double whammy: The effect of length on nonword reading. Psychonomic Bulletin and Review, 5, 277282.
Rastle, K., & Coltheart, M. (1999a). Lexical and nonlexical phonological priming. Journal of Experimental Psychology: Human Perception and Performance, 25, 461481.
Rastle, K., & Coltheart, M. (1999b). Serial and strategic effects in reading aloud. Journal of Experimental Psychology: Human Perception and Performance, 25, 482503.
Rayner, K., Foorman, B., Perfetti, C., Pesetsky, D., & Seidenberg, M. (2001). How psychological science informs the teaching of reading. Psychological Science in the Public Interest, 2, 3174.
Reynolds, M., & Besner, D. (2006). Reading aloud is not automatic: Processing capacity is required to generate a phonological code from print. Journal of Experimental Psychology: Human Perception and Performance, 32, 13031323.
Richards, T., Corina, D., Serafini, S., Steury, K., Echelard, D., Dager, S., et al. (2000). Effects of a phonologically driven treatment for dyslexia on lactate levels measured by proton MRI spectroscopic imaging. American Journal of Neuroradiology, 21, 916922.
Richardson, E., Kupietz, S., Winsberg, B., Maitinsky, S., & Mendell, N. (1988). Effects of methylphenidate dosage in hyperactive reading-disabled children: II. Reading achievement. Journal of the American Academy of Child & Adolescent Psychiatry, 27, 7887.
Roman, T., Schmitz, M., Polanczyk, G., Eizirik, M., Rohde, L., Hutz, M. A. J., et al. (2003). Is the alpha-2A adrenergic receptor gene (ADRA2A) associated with attention-deficit/hyperactivity disorder? American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 120, 116120.
Rumsey, J. M., Andreason, P., Zametkin, A. J., Aquino, T., King, C., Hamburber, S. D., et al. (1992). Failure to activate the left temporoparietal cortex in dyslexia. Archives of Neurology, 49, 527534.
Salmelin, R., Service, E., Kiesila, P., Uutela, K., & Salonen, O. (1996). Impaired visual word processing in dyslexia revealed with magnetoencephalography. Annals of Neurology, 40, 157162.
Schmithorst, V. J., & Holland, S. K. (2006). Functional MRI evidence for disparate developmental processes underlying intelligence in boys and girls. NeuroImage, 31, 13661379.
Schmithorst, V. J., & Holland, S. K. (2007). Sex differences in the development of neuroanatomical functional connectivity underlying intelligence found using Bayesian connectivity analysis. NeuroImage, 35, 406419.
Seki, A., Koeda, T., Sugihara, S., Kamba, M., Hirata, Y., Ogawa, T., et al. (2001). A functional magnetic resonance imaging study during reading in Japanese dyslexic children. Brain & Development, 23, 312316.
Shafritz, K. M., Marchione, K. E., Gore, J. C., Shaywitz, S. E., & Shaywitz, B. A. (2004). The effects of methylphenidate on neural systems of attention in attention deficit hyperactivity disorder. American Journal of Psychiatry, 161, 19901997.
Shaw, P., Lerch, J., Greenstein, D., Sharp, W., Clasen, L., Evans, A., et al. (2006). Longitudinal mapping of cortical thickness and clinical outcome in children and adolescents with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 63, 540549.
Shaywitz, B., Shaywitz, S., Blachman, B., Pugh, K., Fulbright, R., Skudlarski, P., et al. (2004). Development of left occipito-temporal systems for skilled reading in children after a phonologically-based intervention. Biological Psychiatry, 55, 926933.
Shaywitz, B., Shaywitz, S., Pugh, K., Mencl, W., Fulbright, R., Skudlarski, P., et al. (2002a). Disruption of posterior brain systems for reading in children with developmental dyslexia. Biological Psychiatry, 52, 101110.
Shaywitz, B., Skudlarski, P., Holahan, J., Marchione, K., Constable, R., Fulbright, R., et al. (2007). Age-related changes in reading systems of dyslexic children. Annals of Neurology, 61, 363370.
Shaywitz, B. A., Fletcher, J. M., Holahan, J. M., & Shaywitz, S. E. (1992). Discrepancy compared to low achievement definitions of reading disability: Results from the Connecticut Longitudinal Study. Journal of Learning Disabilities, 25, 639648.
Shaywitz, B. A., Holford, T. R., Holahan, J. M., Fletcher, J. M., Stuebing, K. K., Francis, D. J., et al. (1995). A Matthew effect for IQ but not for reading: Results from a longitudinal study. Reading Research Quarterly, 30, 894906.
Shaywitz, B. A., Shaywitz, S. E., Pugh, K. R., Mencl, W. E., Fulbright, R. K., Skudlarski, P., et al. (2002b). Disruption of posterior brain systems for reading in children with developmental dyslexia. Biological Psychiatry, 52, 101110.
Shaywitz, S. (2003). Overcoming dyslexia: A new and complete science-based program for reading problems at any level. New York: Alfred A. Knopf.
Shaywitz, S., Fletcher, J., Holahan, J., Shneider, A., Marchione, K., Stuebing, K., et al. (1999). Persistence of dyslexia: The Connecticut Longitudinal Study at adolescence. Pediatrics, 104, 13511359.
Shaywitz, S., Fletcher, J., & Shaywitz, B. (1994). Issues in the definition and classifiction of attention deficit disorder. Topics in Language Disorders, 14, 125.
Shaywitz, S., Morris, R., & Shaywitz, B. (2008). The education of dyslexic children from childhood to young adulthood. Annual Review of Psychology, 59, 451475.
Shaywitz, S., Shaywitz, B., Fletcher, J., & Escobar, M. (1990). Prevalence of reading disability in boys and girls: Results of the Connecticut Longitudinal Study. Journal of the American Medical Association, 264, 9981002.
Shaywitz, S., Shaywitz, B., Fulbright, R., Skudlarski, P., Mencl, W., Constable, R., et al. (2003). Neural systems for compensation and persistence: Young adult outcome of childhood reading disability. Biological Psychiatry, 54, 2533.
Shaywitz, S., Shaywitz, B., Pugh, K., Fulbright, R., Constable, R., Mencl, W., et al. (1998). Functional disruption in the organization of the brain for reading in dyslexia. Proceedings of the National Academy of Science of the United States of America, 95, 26362641.
Shaywitz, S. E. (1996). Dyslexia. Scientific American, 275, 98104.
Shaywitz, S. E., Escobar, M. D., Shaywitz, B. A., Fletcher, J. M., & Makuch, R. (1992). Evidence that dyslexia may represent the lower tail of a normal distribution of reading ability. New England Journal of Medicine, 326, 145150.
Snowling, M. (2000). Dyslexia (2nd ed.). Oxford: Blackwell.
Starrfelt, R., & Gerlach, C. (2007). The visual what for area: Words and pictures in the left fusiform gyrus. NeuroImage, 35, 334342.
Stein, J. (2003). Visual motion sensitivity and reading. Neuropsychologia, 41, 17851793.
Stein, J., & Walsh, V. (1997). To see but not to read; The magnocellular theory of dyslexia. Trends in Neurosciences, 20, 147152.
Tallal, P. (1980). Auditory temporal perception, phonics, and reading disabilities in children. Brain & Language, 9, 182198.
Tallal, P. (2000). The science of literacy: From the laboratory to the classroom. Proceedings of the National Academy of Science of the United States of America, 97, 24022404.
Tallal, P., Miller, S., & Fitch, R. (1993). Neurobiological basis of speech: A case for the preeminence of temporal processing. Annals of the New York Academy of Science, 682, 2747.
Temple, E., Deutsch, G., Poldrack, R., Miller, S., Tallal, P., Merzenich, M., et al. (2003). Neural deficits in children with dyslexia ameliorated by behavioral remediation: Evidence from fMRI. Proceedings of the National Academy of Science of the United States of America, 100, 28602865.
Temple, E., Poldrack, R., Protopapas, A., Nagarajan, S., Salz, T., Tallal, P., et al. (2000). Disruption of the neural response to rapid acoustic stimuli in dyslexia: Evidence from functional MRI. Proceedings of the National Academy of Science of the United States of America, 97, 1390713912.
Temple, E., Poldrack, R. A., Salidis, J., Deutsch, G. K., Tallal, P., Merzenich, M. M., et al. (2001). Disrupted neural responses to phonological and orthographic processing in dyslexic children: An fMRI study. NeuroReport, 12, 299307.
Torgesen, J., Alexander, A., Wagner, R., Rashotte, C., Voeller, K., & Conway, T. (2001). Intensive remedial instruction for children with severe reading disabilities: Immediate and long-term outcomes from two instructional approaches. Journal of Learning Disabilities, 34, 3358.
Torgesen, J., Wagner, R., & Rashotte, C. (1997). Approaches to the prevention and remediation of phonologically-based reading disabilities. Mahwah, NJ: Erlbaum.
Vaidya, C. J., Austin, G., Kirkorian, G., Ridlehuber, H. W., Desmond, J. E., Glover, G. H., et al. (1998). Selective effects of methylphenidate in attention deficit hyperactivity disorder: A functional magnetic resonance study. Proceedings of the National Academy of Science of the United States of America, 95, 1449414499.
Valera, E., Faraone, S., Murray, K., & Seidman, L. (2007). Meta-analysis of structural imaging findings in attention-deficit/hyperactivity disorder. Biological Psychiatry, 61, 13611369.
Vinckier, F., Dehaene, S., Jobert, A., Dubus, J. P., Sigman, M., & Cohen, L. (2007). Hierarchical coding of letter strings in the ventral stream: Dissecting the inner organization of the visual word-form system. Neuron, 55, 143156.
Vinckier, F., Naccache, L., Papeix, C., Forget, J., Hahn-Barma, V., Dehaene, S., et al. (2006). “What” and “where” in word reading: Ventral coding of written words revealed by parietal atrophy. Journal of Cognitive Neuroscience, 18, 19982012.
Willcutt, E. G., & Pennington, B. F. (2000). Psychiatric comorbidity in children and adolescents with reading disability. Journal of Child Psychology and Psychiatry and Allied Disciplines, 41, 10391048.
Xu, B., Grafman, J., Gaillard, W. D., Ishii, K., Vega-Bermudez, F., Pietrini, P., et al. (2001). Conjoint and extended neural networks for the computation of speech codes: The neural basis of selective impairment in reading words and pseudowords. Cerebral Cortex, 11, 267277.
Xu, B., & Perfetti, C. (1999). Nonstrategic subject threshold effects in phonemic masking. Memory & Cognition, 27, 2636.
Xue, G., Chen, C., Jin, Z., & Dong, Q. (2006). Language experience shapes fusiform activation when processing a logographic artificial language: An fMRI training study. NeuroImage, 31, 13151326.


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