The relationship between a range of prenatal and perinatal events and risk forpsychopathology in offspring was examined. Prenatal and perinatal events investigated includedmaternal experiences, health, and substance use during pregnancy, obstetric complications,feeding practices, and infant health during the first year of life. Offspring diagnosis was based onstructured interviews conducted with 579 adolescents on two occasions. Risk for laterpsychopathology was associated with a number of prenatal and perinatal factors. Majordepression was associated with not being breast fed and maternal emotional problems during thepregnancy. Anxiety was chiefly associated with fever and illness during the first year of life andmaternal history of miscarriage and stillbirth. Disruptive behavior disorder was associated withpoor maternal emotional health during the pregnancy and birth complications. Risk for substanceuse disorder was associated with maternal use of substances during the pregnancy. Mediatingeffects of maternal depression, maternal–child conflict, and physical symptoms in thechild, and moderating effects of gender of child and parental education were also evaluated. Thelimitations of this study are discussed and future research directions are suggested.