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The relationship between hippocampal asymmetry and temperament in adolescent borderline and antisocial personality pathology

Published online by Cambridge University Press:  25 November 2013

Martina Jovev ,
Sarah Whittle ,
Murat Yücel ,
Julian Guy Simmons ,
Nicholas B. Allen  and
Andrew M. Chanen
Martina Jovev
Affiliation:
University of Melbourne, Melbourne Northwestern Mental Health, Melbourne
Sarah Whittle
Affiliation:
University of Melbourne, Melbourne
Murat Yücel
Affiliation:
University of Melbourne, Melbourne
Julian Guy Simmons
Affiliation:
University of Melbourne, Melbourne
Nicholas B. Allen
Affiliation:
University of Melbourne, Melbourne
Andrew M. Chanen*
Affiliation:
University of Melbourne, Melbourne Northwestern Mental Health, Melbourne
*
Address correspondence and reprint requests to: Andrew Chanen, Orygen Youth Health Research Centre, Locked Bag 10, Parkville, VC 3052, Australia; E-mail: achanen@unimelb.edu.au.
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Abstract

Investigating etiological processes early in the life span represents an important step toward a better understanding of the development of personality pathology. The current study evaluated the interaction between an individual difference risk factor (i.e., temperament) and a biological risk factor for aggressive behavior (i.e., atypical [larger] rightward hippocampal asymmetry) in predicting the emergence of borderline personality disorder (BPD) and antisocial personality disorder symptoms during early adolescence. The sample consisted of 153 healthy adolescents (M = 12.6 years, SD = 0.4, range = 11.4–13.7) who were selected from a larger sample to maximize variation in temperament. Interactions between four temperament factors (effortful control, negative affectivity, surgency, and affiliativeness), based on the Early Adolescent Temperament Questionnaire—Revised, and volumetric measures of hippocampal asymmetry were examined as cross-sectional predictors of BPD and antisocial personality disorder symptoms. Boys were more likely to have elevated BPD symptoms if they were high on affiliation and had larger rightward hippocampal asymmetry. In boys, low affiliation was a significant predictor of BPD symptoms in the presence of low rightward hippocampal asymmetry. For girls, low effortful control was associated with elevated BPD symptoms in the presence of atypical rightward hippocampal asymmetry. This study builds on previous work reporting significant associations between atypical hippocampal asymmetry and poor behavioral regulation.

Type
Regular Articles
Information
Development and Psychopathology , Volume 26 , Issue 1 , February 2014 , pp. 275 - 285
Copyright
Copyright © Cambridge University Press 2013 

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