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The role of the amygdala in bipolar disorder development

  • Amy Garrett (a1) and Kiki Chang (a1)

The amygdala has received great interest as a possible neurophysiological substrate of bipolar disorder (BD). This review summarizes information about the structure and function of the amygdala with attention to its role in experienced emotion and mood. We review the evidence for amygdala pathology in psychiatric conditions and discuss the role of the amygdala in BD during development. There appear to be consistent findings in the neuroimaging literature that suggest an etiological model for BD that involves abnormalities in the structure and function of the amygdala, but also depends on the failure of prefrontal cortical regions to modulate amygdala activity. In addition, evidence is accumulating to suggest that this model has flexible outcomes, depending on factors intrinsic and extrinsic to BD, and may follow several possible paths across the course of maturational development.

Corresponding author
Address correspondence and reprint requests to: Kiki D. Chang, Division of Child and Adolescent Psychiatry, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305-5540; E-mail:
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Both authors shared equally in the preparation of the manuscript. This work was supported by NIH Grant 5RO1MH077047 (to K.C.).

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Adolphs R., Tranel D., & Damasio A. R. (1998). The human amygdala in social judgment. Nature, 393, 470474.
Altshuler L. L., Bartzokis G., Grieder T., Curran J., Jimenez T., Leight K. et al. (2000). An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia. Biological Psychiatry, 48, 147162.
Altshuler L. L., Bookheimer S., Proenza M. A., Townsend J., Sabb F., Firestine A., et al. (2005). Increased amygdala activation during mania: A functional magnetic resonance imaging study. American Journal of Psychiatry, 162, 12111213.
Amaral D. G., Bauman M. D., Capitanio J. P., Lavenex P., Mason W. A., Mauldin-Jourdain M. L., et al. (2003). The amygdala: Is it an essential component of the neural network for social cognition? Neuropsychologia, 41, 517522..
Amaral D. G., Behniea H., & Kelly J. L. (2003). Topographic organization of projections from the amygdala to the visual cortex in the macaque monkey. Neuroscience, 118, 10991120.
Anderson A. K., & Phelps E. A. (2001). Lesions of the human amygdala impair enhanced perception of emotionally salient events. Nature, 411, 305309.
Anderson A. K., & Phelps E. A. (2002). Is the human amygdala critical for the subjective experience of emotion? Evidence of intact dispositional affect in patients with amygdala lesions. Journal of Cognitive Neuroscience, 14, 709720.
Aroniadou-Anderjaska V., Fritsch B., Qashu F., & Braga M. F. (2008). Pathology and pathophysiology of the amygdala in epileptogenesis and epilepsy. Epilepsy Research, 78, 102116.
Aroniadou-Anderjaska V., Qashu F., & Braga M. F. (2007). Mechanisms regulating GABAergic inhibitory transmission in the basolateral amygdala: Implications for epilepsy and anxiety disorders. Amino Acids, 32, 305315.
Bachevalier J. (2000). The amygdala, social behavior, and autism. In Aggleton J. P. (Ed.), The amygdala: A functional analysis. New York: Oxford University Press.
Bachevalier J., & Loveland K. A. (2006). The orbitofrontal–amygdala circuit and self-regulation of social-emotional behavior in autism. Neuroscience and Biobehavioral Reviews, 30, 97117.
Bachevalier J., & Malkova L. (2006). The amygdala and development of social cognition: Theoretical comment on Bauman, Toscano, Mason, Lavenex, and Amaral. Behavioral Neuroscience, 120, 989991.
Baird A. A., Gruber S. A., Fein D. A., Maas L. C., Steingard R. J., Renshaw P. F., et al. (1999). Functional magnetic resonance imaging of facial affect recognition in children and adolescents. Journal of the American Academy of Child & Adolescent Psychiatry, 38, 195199.
Barad M., Gean P. W., & Lutz B. (2006). The role of the amygdala in the extinction of conditioned fear. Biological Psychiatry, 60, 322328.
Bauman M. D., Lavenex P., Mason W. A., Capitanio J. P., & Amaral D. G. (2004). The development of social behavior following neonatal amygdala lesions in rhesus monkeys. Journal of Cognitive Neuroscience, 16, 13881411.
Baxter M. G., & Murray E. A. (2002). The amygdala and reward. Nature Reviews. Neuroscience, 3, 563573.
Blair R. J., Peschardt K. S., Budhani S., Mitchell D. G., & Pine D. S. (2006). The development of psychopathy. Journal of Child Psychology and Psychiatry, 47, 262276.
Blumberg H. P., Charney D. S., & Krystal J. H. (2002). Frontotemporal neural systems in bipolar disorder. Seminars in Clinical Neuropsychiatry, 7, 243254.
Blumberg H. P., Donegan N. H., Sanislow C. A., Collins S., Lacadie C., Skudlarski P., et al. (2005). Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder. Psychopharmacology (Berlin), 183, 308313.
Blumberg H. P., Fredericks C., Wang F., Kalmar J. H., Spencer L., Papademetris X., et al. (2005). Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder. Bipolar Disorders, 7, 570576.
Blumberg H. P., Kaufman J., Martin A., Whiteman R., Zhang J. H., Gore J. C., et al. (2003). Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Archives of General Psychiatry, 60, 12011208.
Bowley M. P., Drevets W. C., Ongur D., & Price J. L. (2002). Low glial numbers in the amygdala in major depressive disorder. Biological Psychiatry, 52, 404412.
Braesicke K., Parkinson J. A., Reekie Y., Man M. S., Hopewell L., Pears A., et al. (2005). Autonomic arousal in an appetitive context in primates: A behavioural and neural analysis. European Journal of Neuroscience, 21, 17331740.
Brambilla P., Harenski K., Nicoletti M. A., Mallinger A. G., Frank E., Kupfer D. J., et al. (2001). Anatomical MRI study of basal ganglia in bipolar disorder patients. Psychiatry Research, 106, 6580.
Brandt C., Ebert U. & Loscher W. (2004). Epilepsy induced by extended amygdala-kindling in rats: Lack of clear association between development of spontaneous seizures and neuronal damage. Epilepsy Research, 62, 135156.
Bremner J. D., Narayan M., Anderson E. R., Staib L. H., Miller H. L., & Charney D. S. (2000). Hippocampal volume reduction in major depression. American Journal of Psychiatry, 157, 115118.
Caetano S. C., Hatch J. P., Brambilla P., Sassi R. B., Nicoletti M., Mallinger A. G., et al. (2004). Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression. Psychiatry Research, 132, 141147.
Cahill L., Haier R. J., Fallon J., Alkire M. T., Tang C., Keator D., et al. (1996). Amygdala activity at encoding correlated with long-term, free recall of emotional information. Proceedings of the National Academy of Science of the United States of America, 93, 80168021.
Canli T. (2004). Functional brain mapping of extraversion and neuroticism: Learning from individual differences in emotion processing. Journal of Personality, 72, 11051132.
Canli T., Sivers H., Whitfield S. L., Gotlib I. H., & Gabrieli J. D. (2002). Amygdala response to happy faces as a function of extraversion. Science, 296, 2191.
Canli T., Zhao Z., Brewer J., Gabrieli J. D., & Cahill L. (2000). Event-related activation in the human amygdala associates with later memory for individual emotional experience. Journal of Neuroscience, 20, RC99.
Chang K., Adleman N., Dienes K., Barnea-Goraly N., Reiss A., & Ketter T. (2003). Decreased N-acetylaspartate in children with familial bipolar disorder. Biological Psychiatry, 53, 10591065.
Chang K., Adleman N. E., Dienes K., Simeonova D. I., Menon V., & Reiss A. (2004). Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: A functional magnetic resonance imaging investigation. Archives of General Psychiatry, 61, 781792.
Chang K., Howe M., Gallelli K., & Miklowitz D. (2006). Prevention of pediatric bipolar disorder: Integration of neurobiological and psychosocial processes. Annals of the New York Academy of Science, 1094, 235247.
Chang K., Karchemskiy A., Barnea-Goraly N., Garrett A., Simeonova D. I., & Reiss A. (2005). Reduced amygdalar gray matter volume in familial pediatric bipolar disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 44, 565573.
Chang K. D., Wagner C., Garrett A., Howe M., & Reiss A. (2008). A preliminary functional magnetic resonance imaging study of prefrontal–amygdalar activation changes in adolescents with bipolar depression treated with lamotrigine. Bipolar Disorders 10, 426431.
Cicchetti D., & Blender J. A. (2006). A multiple-levels-of-analysis perspective on resilience: Implications for the developing brain, neural plasticity, and preventive interventions. Annals of the New York Academy of Science, 1094, 248258.
DelBello M. P., Zimmerman M. E., Mills N. P., Getz G. E., & Strakowski S. M. (2004). Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder. Bipolar Disorders, 6, 4352.
Dickstein D. P., Milham M. P., Nugent A. C., Drevets W. C., Charney D. S., Pine D. S., et al. (2005). Frontotemporal alterations in pediatric bipolar disorder: Results of a voxel-based morphometry study. Archives of General Psychiatry, 62, 734741.
Dolcos F., LaBar K. S., & Cabeza R. (2004). Interaction between the amygdala and the medial temporal lobe memory system predicts better memory for emotional events. Neuron, 42, 855863.
Doty T. J., Payne M. E., Steffens D. C., Beyer J. L., Krishnan K. R., & Labar K. S. (2008). Age-dependent reduction of amygdala volume in bipolar disorder. Psychiatry Research, 163, 8494.
Drevets W. C., Price J. L., Simpson J. R. Jr., Todd R. D., Reich T., Vannier M., et al. (1997). Subgenual prefrontal cortex abnormalities in mood disorders. Nature, 386, 824827.
Emery N. J., Capitanio J. P., Mason W. A., Machado C. J., Mendoza S. P., & Amaral D. G. (2001). The effects of bilateral lesions of the amygdala on dyadic social interactions in rhesus monkeys (Macaca mulatta). Behavioral Neuroscience, 115, 515544.
Etkin A., & Wager T. D. (2007). Functional neuroimaging of anxiety: A meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. American Journal of Psychiatry, 164, 14761488.
Foland L. C., Altshuler L. L., Bookheimer S. Y., Eisenberger N., Townsend J., & Thompson P. M. (2008). Evidence for deficient modulation of amygdala response by prefrontal cortex in bipolar mania. Psychiatry Research, 162, 2737.
Foland L. C., Altshuler L. L., Sugar C. A., Lee A. D., Leow A. D., Townsend J., et al. (2008). Increased volume of the amygdala and hippocampus in bipolar patients treated with lithium. NeuroReport, 19, 221224.
Frazier J. A., Ahn M. S., DeJong S., Bent E. K., Breeze J. L., & Giuliano A. J. (2005). Magnetic resonance imaging studies in early-onset bipolar disorder: A critical review. Harvard Review of Psychiatry, 13, 125140.
Frodl T., Meisenzahl E., Zetzsche T., Bottlender R., Born C., Groll C., Jager M., et al. (2002). Enlargement of the amygdala in patients with a first episode of major depression. Biological Psychiatry, 51, 708714.
Garrett A. S., & Maddock R. J. (2006). Separating subjective emotion from the perception of emotion-inducing stimuli: An fMRI study. NeuroImage, 33, 263274.
Goossens L., Sunaert S., Peeters R., Griez E. J., & Schruers K. R. (2007). Amygdala hyperfunction in phobic fear normalizes after exposure. Biological Psychiatry, 62, 11191125.
Hamilton J. P., & Gotlib I. H. (2008). Neural substrates of increased memory sensitivity for negative stimuli in major depression. Biological Psychiatry, 63, 11551162.
Hastings R. S., Parsey R. V., Oquendo M. A., Arango V., & Mann J. J. (2004). Volumetric analysis of the prefrontal cortex, amygdala, and hippocampus in major depression. Neuropsychopharmacology, 29, 952959.
Kalin N. H., Shelton S. E., Davidson R. J., & Kelley A. E. (2001). The primate amygdala mediates acute fear but not the behavioral and physiological components of anxious temperament. Journal of Neuroscience, 21, 20672074.
Ketter T. A., Andreason P. J., George M. S., Lee C., Gill D. S., Parekh P. I., et al. (1996). Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences. Archives of General Psychiatry, 53, 5969.
Ketter T. A., & Wang P. W. (2003). The emerging differential roles of GABAergic and antiglutamatergic agents in bipolar disorders. Journal of Clinical Psychiatry, 64(Suppl. 3), 1520.
Killgore W. D., & Yurgelun-Todd D. A. (2005). Social anxiety predicts amygdala activation in adolescents viewing fearful faces. NeuroReport, 16, 16711675.
Kluver H., & Bucy P. (1938). An analysis of certain effects of bilateral temporal lobectomy in the rhesus monkey with special reference to psychic blindness. Journal of Psychology, 5, 3354.
Koob G. F., & Le Moal M. (2008). Addiction and the brain antireward system. Annual Review of Psychology, 59, 2953.
LaBar K. S., Gatenby J. C., Gore J. C., LeDoux J. E., & Phelps E. A. (1998). Human amygdala activation during conditioned fear acquisition and extinction: A mixed-trial fMRI study. Neuron, 20, 937945.
Lane R. D., Reiman E. M., Bradley M. M., Lang P. J., Ahern G. L., Davidson R. J., et al. (1997). Neuroanatomical correlates of pleasant and unpleasant emotion. Neuropsychologia, 35, 14371444.
Lau J. Y., Lissek S., Nelson E. E., Lee Y., Roberson-Nay R., Poeth K., et al. (2008). Fear conditioning in adolescents with anxiety disorders: Results from a novel experimental paradigm. Journal of the American Academy of Child & Adolescent Psychiatry, 47, 94102.
LeDoux J. (2007). The amygdala. Current Biology, 17, R868R874.
LeDoux J. E. (1994). Emotion, memory and the brain. Scientific American, 270, 5057.
LeDoux J. E. (2000). Emotion circuits in the brain. Annual Review of Neuroscience, 23, 155184.
Lembke A., & Ketter T. A. (2002). Impaired recognition of facial emotion in mania. American Journal of Psychiatry, 159, 302304.
Machado C. J., Snyder A. Z., Cherry S. R., Lavenex P., & Amaral D. G. (2008). Effects of neonatal amygdala or hippocampus lesions on resting brain metabolism in the macaque monkey: A microPET imaging study. NeuroImage, 39, 832846.
MacMillan S., Szeszko P. R., Moore G. J., Madden R., Lorch E., Ivey J., et al. (2003). Increased amygdala: Hippocampal volume ratios associated with severity of anxiety in pediatric major depression. Journal of Child and Adolescent Psychopharmacology, 13, 6573.
McClure E. B., Adler A., Monk C. S., Cameron J., Smith S., Nelson E. E., et al. (2007). fMRI predictors of treatment outcome in pediatric anxiety disorders. Psychopharmacology (Berlin), 191, 97105.
McClure E. B., Pope K., Hoberman A. J., Pine D. S., & Leibenluft E. (2003). Facial expression recognition in adolescents with mood and anxiety disorders. American Journal of Psychiatry, 160, 11721174.
McClure E. B., Treland J. E., Snow J., Schmajuk M., Dickstein D. P., Towbin K. E., et al. (2005). Deficits in social cognition and response flexibility in pediatric bipolar disorder. American Journal of Psychiatry, 162, 16441651.
McGaugh J. L. (2000). Memory—A century of consolidation. Science, 287, 248251.
Medina J. F., Repa J. C., Mauk M. D., & LeDoux J. E. (2002). Parallels between cerebellum- and amygdala-dependent conditioning. Nature Reviews. Neuroscience, 3, 122131.
Meunier M., Bachevalier J., Murray E. A., Malkova L., & Mishkin M. (1999). Effects of aspiration versus neurotoxic lesions of the amygdala on emotional responses in monkeys. European Journal of Neuroscience, 11, 44034418.
Milham M. P., Nugent A. C., Drevets W. C., Dickstein D. P., Leibenluft E., Ernst M., et al. (2005). Selective reduction in amygdala volume in pediatric anxiety disorders: A voxel-based morphometry investigation. Biological Psychiatry, 57, 961966.
Monk C. S., Grillon C., Baas J. M., McClure E. B., Nelson E. E., Zarahn E., et al. (2003). A neuroimaging method for the study of threat in adolescents. Development and Psychobiology, 43, 359366.
Monk C. S., Telzer E. H., Mogg K., Bradley B. P., Mai X., Louro H. M., et al. (2008). Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. Archives of General Psychiatry, 65, 568576.
Moore G. J., Bebchuk J. M., Wilds I. B., Chen G., & Manji H. K. (2000). Lithium-induced increase in human brain grey matter. Lancet, 356, 12411242.
Nithianantharajah J., & Murphy M. (2008). Auditory specific fear conditioning results in increased levels of synaptophysin in the basolateral amygdala. Neurobiology of Learning and Memory, 90, 3643.
Pavuluri M. N., O'Connor M. M., Harral E., & Sweeney J. A. (2007). Affective neural circuitry during facial emotion processing in pediatric bipolar disorder. Biological Psychiatry, 62, 158167.
Pavuluri M. N., O'Connor M. M., Harral E. M., & Sweeney J. A. (2008). An fMRI study of the interface between affective and cognitive neural circuitry in pediatric bipolar disorder. Psychiatry Research, 162, 244255.
Pearlson G. D., Barta P. E., Powers R. E., Menon R. R., Richards S. S., Aylward E. H. et al. (1997). Ziskind–Somerfeld Research Award 1996. Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biological Psychiatry, 41, 114.
Phelps E. A. (2006). Emotion and cognition: Insights from studies of the human amygdala. Annual Review of Psychology, 57, 2753.
Phelps E. A., & LeDoux J. E. (2005). Contributions of the amygdala to emotion processing: From animal models to human behavior. Neuron, 48, 175187.
Pine D. S. (2007). Research review: A neuroscience framework for pediatric anxiety disorders. Journal of Child Psychology and Psychiatry, 48, 631648.
Plessen K. J., Bansal R., Zhu H., Whiteman R., Amat J., Quackenbush G. A., et al. (2006). Hippocampus and amygdala morphology in attention-deficit/hyperactivity disorder. Archives of General Psychiatry, 63, 795807.
Post R. M. (1992). Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. American Journal of Psychiatry, 149, 9991010.
Post R. M., & Leverich G. S. (2006). The role of psychosocial stress in the onset and progression of bipolar disorder and its comorbidities: The need for earlier and alternative modes of therapeutic intervention. Development and Psychopathology, 18, 11811211.
Post R. M., Leverich G. S., Xing G., & Weiss R. B. (2001). Developmental vulnerabilities to the onset and course of bipolar disorder. Development and Psychopathology, 13, 581598.
Radwanska K., Nikolaev E., Knapska E., & Kaczmarek L. (2002). Differential response of two subdivisions of lateral amygdala to aversive conditioning as revealed by c-Fos and P-ERK mapping. NeuroReport, 13, 22412246.
Rauch S. L., Shin L. M., & Wright C. I. (2003). Neuroimaging studies of amygdala function in anxiety disorders. Annals of the New York Academy of Science, 985, 389410.
Rich B. A., Vinton D. T., Roberson-Nay R., Hommer R. E., Berghorst L. H., McClure E. B., et al. (2006). Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder. Proceedings of the National Academy of Science of the United States of America, 103, 89008905.
Roozendaal B., Barsegyan A., & Lee S. (2008). Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiences. Progress in Brain Research, 167, 7997.
Roozendaal B., Brunson K. L., Holloway B. L., McGaugh J. L., & Baram T. Z. (2002). Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation. Proceedings of the National Academy of Science of the United States of America, 99, 1390813913.
Rosso I. M., Killgore W. D., Cintron C. M., Gruber S. A., Tohen M., & Yurgelun-Todd D. A. (2007). Reduced amygdala volumes in first-episode bipolar disorder and correlation with cerebral white matter. Biological Psychiatry, 61, 743749.
Schneider F., Grodd W., Weiss U., Klose U., Mayer K. R., Nagele T., et al. (1997). Functional MRI reveals left amygdala activation during emotion. Psychiatry Research, 76, 7582.
Shekhar A., Truitt W., Rainnie D., & Sajdyk T. (2005). Role of stress, corticotrophin releasing factor (CRF) and amygdala plasticity in chronic anxiety. Stress, 8, 209219.
Sheline Y. I., Gado M. H., & Price J. L. (1998). Amygdala core nuclei volumes are decreased in recurrent major depression. NeuroReport, 9, 20232028.
Siegle G. J., Konecky R. O., Thase M. E., & Carter C. S. (2003). Relationships between amygdala volume and activity during emotional information processing tasks in depressed and never-depressed individuals: An fMRI investigation. Annals of the New York Academy of Science, 985, 481484.
Silbersweig D., Clarkin J. F., Goldstein M., Kernberg O. F., Tuescher O., Levy K. N., et al. (2007). Failure of frontolimbic inhibitory function in the context of negative emotion in borderline personality disorder. American Journal of Psychiatry, 164, 18321841.
Smith M. E. (2005). Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: A meta-analysis of structural MRI studies. Hippocampus, 15, 798807.
Somerville L. H., Wig G. S., Whalen P. J., & Kelley W. M. (2006). Dissociable medial temporal lobe contributions to social memory. Journal of Cognitive Neuroscience, 18, 12531265.
Sommer M., Dohnel K., Meinhardt J., & Hajak G. (2008). Decoding of affective facial expressions in the context of emotional situations. Neuropsychologia.
Stein D. J., Westenberg H. G., & Liebowitz M. R. (2002). Social anxiety disorder and generalized anxiety disorder: Serotonergic and dopaminergic neurocircuitry. Journal of Clinical Psychiatry, 63(Suppl. 6), 1219.
Strakowski S. M., DelBello M. P., Sax K. W., Zimmerman M. E., Shear P. K., Hawkins J. M. et al. (1999). Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Archives of General Psychiatry, 56, 254260.
Strakowski S. M., DelBello M. P., Zimmerman M. E., Getz G. E., Mills N. P., Ret J., et al. (2002). Ventricular and periventricular structural volumes in first- versus multiple-episode bipolar disorder. American Journal of Psychiatry, 159, 18411847.
Surguladze S., Brammer M. J., Keedwell P., Giampietro V., Young A. W., Travis M. J., et al. (2005). A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder. Biological Psychiatry, 57, 201209.
Swayze V. W. 2nd, Andreasen N. C., Alliger R. J., Yuh W. T., & Ehrhardt J. C. (1992). Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study. Biological Psychiatry, 31, 221240.
Thomas K. M., Drevets W. C., Dahl R. E., Ryan N. D., Birmaher B., Eccard C. H., et al. (2001). Amygdala response to fearful faces in anxious and depressed children. Archives of General Psychiatry, 58, 10571063.
Warner-Schmidt J. L., & Duman R. S. (2006). Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment. Hippocampus, 16, 239249.
Whalen P. J., Johnstone T., Somerville L. H., Nitschke J. B., Polis S., Alexander A. L., et al. (2008). A functional magnetic resonance imaging predictor of treatment response to venlafaxine in generalized anxiety disorder. Biological Psychiatry, 63, 858863.
Whittle S., Allen N. B., Lubman D. I., & Yucel M. (2006). The neurobiological basis of temperament: Towards a better understanding of psychopathology. Neuroscience and Biobehavioral Review, 30, 511525.
Yang T. T., Menon V., Reid A. J., Gotlib I. H., & Reiss A. L. (2003). Amygdalar activation associated with happy facial expressions in adolescents: A 3-T functional MRI study. Journal of the American Academy of Child & Adolescent Psychiatry, 42, 979985.
Yurgelun-Todd D. A., Gruber S. A., Kanayama G., Killgore W. D., Baird A. A., & Young A. D. (2000). fMRI during affect discrimination in bipolar affective disorder. Bipolar Disorders, 2(Pt. 2), 237248.
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