Hostname: page-component-7dd5485656-c8zdz Total loading time: 0 Render date: 2025-10-31T16:30:05.243Z Has data issue: false hasContentIssue false
  • English
  • Français

Social endophenotypes in autism spectrum disorder: A scoping review

Published online by Cambridge University Press:  20 July 2020

Gabrielle M. Tiede Open the ORCID record for Gabrielle M. Tiede [Opens in a new window]  and
Katherine M. Walton
Gabrielle M. Tiede*
Affiliation:
The Ohio State University, Columbus, OH, USA
Katherine M. Walton
Affiliation:
The Ohio State University, Columbus, OH, USA
*
Author for correspondence: Gabrielle M. Tiede MA, The Ohio State University, 241 McCampbell Hall, 1581 Dodd Drive, Columbus, Ohio 43210-1257, USA. Email: Gabrielle.Tiede@osumc.edu
Get access Rights & Permissions [Opens in a new window]

Abstract

Endophenotypes are measurable markers of genetic vulnerability to current or future disorder. Autism spectrum disorder (ASD) is well-suited to be examined within an endophenotype framework given past and current emphases on the broader autism phenotype and early detection. We conducted a scoping review to identify potential socially-related endophenotypes of ASD. We focused on paradigms related to sociality (e.g., theory of mind (TOM), social attention), which comprise most of this literature. We integrated findings from traditional behavioral paradigms with brain-based measures (e.g., electroencephalography, functional magnetic resonance imaging). Broadly, infant research regarding social attention and responsivity (Research Domain Criteria (RDoC) domain of affiliation) and attention to faces and voices (social communication) finds consistent abnormality in vulnerable infant siblings. Several additional paradigms that have shown differences in vulnerable infants and young children include animacy perception tasks (perception and understanding of others), measures of recognition and response to familiar faces (attachment), and joint attention and false-belief tasks (understanding mental states). Research areas such as alexithymia (the perception and understanding of self), empathic responding, and vocal prosody may hold interest; however, challenges in measurement across populations and age ranges is a limiting factor. Future work should address sex differences and age dependencies, specificity to ASD, and heterogeneous genetic pathways to disorder within samples individuals with ASD and relatives.

Keywords

autismearly detectionendophenotypes

Information

Type
Regular Articles
Information
Development and Psychopathology , Volume 33 , Issue 4 , October 2021 , pp. 1381 - 1409
Check for updates
Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author.Google Scholar
Adolphs, R., Spezio, M. L., Parlier, M., & Piven, J. (2008). Distinct face-processing strategies in parents of autistic children. Current Biology: CB, 18, 1090–1093. doi:10.1016/j.cub.2008.06.073CrossRefGoogle ScholarPubMed
Ahmed, A. A., & Vander Wyk, B. C. (2013). Neural processing of intentional biological motion in unaffected siblings of children with autism spectrum disorder: An fMRI study. Brain and Cognition, 83, 297–306. doi:10.1016/j.bandc.2013.09.007CrossRefGoogle Scholar
Ainsworth, M., Blehar, M. C., Waters, E., & Wall, S. N. (1978). Patterns of Attachment. Hillsdale, NJ: Erlbaum.Google Scholar
Ankenman, K., Elgin, J., Sullivan, K., Vincent, L., & Bernier, R. (2014). Nonverbal and verbal cognitive discrepancy profiles in autism spectrum disorders: Influence of age and gender. American Journal on Intellectual and Developmental Disabilities, 119, 84–99. doi:10.1352/1944-7558-119.1.84CrossRefGoogle ScholarPubMed
Åsberg Johnels, J., Hovey, D., Zürcher, N., Hippolyte, L., Lemonnier, E., Gillberg, C., & Hadjikhani, N. (2017). Autism and emotional face-viewing. Autism Research, 10, 901–910. doi:10.1002/aur.1730CrossRefGoogle ScholarPubMed
Baron-Cohen, S. (1988). Social and pragmatic deficits in autism: Cognitive or affective? Journal of Autism and Developmental Disorders, 18, 379–402. doi:10.1007/BF02212194CrossRefGoogle ScholarPubMed
Baron-Cohen, S. (1991a). The development of a theory of mind in autism: Deviance and delay? Psychiatric Clinics of North America, 14, 33–51.CrossRefGoogle Scholar
Baron-Cohen, S. (1991b). Precursors to a theory of mind: Understanding attention in others. In Whiten, A. (Ed.), Natural theories of mind: Evolution, development and simulation of everyday mindreading (pp. 233–251). Cambridge, MA: Basil Blackwell.Google Scholar
Baron-Cohen, S. (2000). Theory of mind and autism: A fifteen year review. In Baron-Cohen, S., Tager-Flusberg, H., & Cohen, D. J. (Eds.), Understanding other minds: Perspectives from developmental cognitive neuroscience (2nd ed., pp. 3–20). New York, NY: Oxford University Press.Google Scholar
Baron-Cohen, S., & Hammer, J. (1997). Parents of children with Asperger syndrome: What is the cognitive phenotype? Journal of Cognitive Neuroscience, 9, 548–554. doi:10.1162/jocn.1997.9.4.548CrossRefGoogle ScholarPubMed
Baron-Cohen, S., Jolliffe, T., Mortimore, C., & Robertson, M. (1997). Another advanced test of theory of mind: Evidence from very high functioning adults with autism or Asperger syndrome. Journal of Child Psychology and Psychiatry, 38(7), 813–822. doi:10.1111/jcpp.1997.38.issue-7CrossRefGoogle ScholarPubMed
Baron-Cohen, S., Ring, H., Chitnis, X., Wheelwright, S., Gregory, L., Williams, S., & Bullmore, E. (2006). fMRI of parents of children with Asperger syndrome: A pilot study. Brain and Cognition, 61, 122–130. doi:10.1016/j.bandc.2005.12.011CrossRefGoogle ScholarPubMed
Baron‐Cohen, S., Wheelwright, S., Hill, J., Raste, Y., & Plumb, I. (2003). The “Reading the Mind in the Eyes” test revised version: A study with normal adults, and adults with Asperger syndrome or high‐functioning autism. Journal of Child Psychology and Psychiatry, 42(2), 241–251. doi:10.1111/jcpp.2001.42.issue-2CrossRefGoogle Scholar
Beauchaine, T., & Cicchetti, D. (2019). Emotion dysregulation and emerging psychopathology: A transdiagnostic, transdisciplinary perspective. Development and Psychopathology, 31, 799–804. doi:10.1017/S0954579419000671CrossRefGoogle ScholarPubMed
Beauchaine, T., & Constantino, J. (2017). Redefining the endophenotype concept to account for transdiagnostic vulnerabilities and etiological complexity. Biomarkers in Medicine (online only). Retrieved from doi:10.2217/bmm-2017-0002CrossRefGoogle Scholar
Beauchaine, T. P., Constantino, J. N., & Hayden, E. P. (2018). Psychiatry and developmental psychopathology: Unifying themes and future directions. Comprehensive Psychiatry, 87, 143–152. doi:10.1016/j.comppsych.2018.10.014CrossRefGoogle ScholarPubMed
Beauchaine, T. P., & Marsh, P. (2006). Taxometric methods: Enhancing early detection and prevention of psychopathology by identifying latent vulnerability traits. In Cicchetti, D., Cohen, D. J., Cicchetti, D., & Cohen, D. J. (Eds.), Developmental psychopathology: Theory and method (Vol. 1, 2nd ed., pp. 931–967). Hoboken, NJ, US: Wiley.Google Scholar
Beauchaine, T. P., Neuhaus, E., Brenner, S. L., & Gatzke-Kopp, L. (2008). Ten good reasons to consider biological processes in prevention and intervention research. Development and Psychopathology, 20, 745–774. doi:10.1017/S095457940800036CrossRefGoogle ScholarPubMed
Bedford, R., Jones, E. J. H., Johnson, M. H., Pickles, A., Charman, T., & Gliga, T. (2016). Sex differences in the association between infant markers and later autistic traits. Molecular Autism, 7, 1–11. doi:10.1186/s13229-016-0081-0Google ScholarPubMed
Bedford, R., Pickles, A., Gliga, T., Elsabbagh, M., Charman, T., & Johnson, M. H. (2014). Additive effects of social and non-social attention during infancy relate to later autism spectrum disorder. Developmental Science, 17, 612–620. doi:10.1111/desc.12139CrossRefGoogle ScholarPubMed
Bernhardt, B. C., Valk, S. L., Silani, G., Bird, G., Frith, U., & Singer, T. (2014). Selective disruption of sociocognitive structural brain networks in autism and alexithymia. Cerebral Cortex, 24, 3258–3267. doi:10.1093/cercor/bht182CrossRefGoogle ScholarPubMed
Berthoz, S., Lalanne, C., Crane, L., & Hill, E. L. (2013). Investigating emotional impairments in adults with autism spectrum disorders and the broader autism phenotype. Psychiatry Research, 208, 257–264. doi:10.1016/j.psychres.2013.05.014CrossRefGoogle ScholarPubMed
Bettelheim, B. (1967). The empty fortress: Infantile autism and the birth of the self. Oxford: Free Press of Glencoe.Google Scholar
Billeci, L., Calderoni, S., Conti, E., Gesi, C., Carmassi, C., Dell'Osso, L., … Guzzetta, A. (2016). The broad autism (endo)phenotype: Neurostructural and neurofunctional correlates in parents of individuals with autism spectrum disorders. Frontiers in Neuroscience, 10, 346. doi:10.3389/fnins.2016.00346CrossRefGoogle ScholarPubMed
Bird, G., Silani, G., Brindley, R., White, S., Frith, U., & Singer, T. (2010). Empathic brain responses in insula are modulated by levels of alexithymia but not autism. Brain: A Journal of Neurology, 133, 1515–1525. doi:10.1093/brain/awq060CrossRefGoogle Scholar
Bölte, S., & Poustka, F. (2003). The recognition of facial affect in autistic and schizophrenic subjects and their first-degree relatives. Psychological Medicine, 33, 907–915.CrossRefGoogle ScholarPubMed
Brambilla, P., Hardan, A., di Nemi, S. U., Perez, J., Soares, J. C., & Barale, F. (2003). Brain anatomy and development in autism: Review of structural MRI studies. Brain Research Bulletin, 61, 557–569. doi:10.1016/j.brainresbull.2003.06.001CrossRefGoogle ScholarPubMed
Braukmann, R., Lloyd-Fox, S., Blasi, A., Johnson, M. H., Bekkering, H., Buitelaar, J. K., & Hunnius, S. (2018). Diminished socially selective neural processing in 5-month-old infants at high familial risk of autism. European Journal of Neuroscience, 47, 720–728. doi:10.1111/ejn.13751CrossRefGoogle ScholarPubMed
Campbell, S. B., Leezenbaum, N. B., Mahoney, A. S., Moore, E. L., & Brownell, C. A. (2016). Pretend play and social engagement in toddlers at high and low genetic risk for autism spectrum disorder. Journal of Autism and Developmental Disorders, 46, 2305–2316. doi:10.1007/s10803-016-2764-yCrossRefGoogle ScholarPubMed
Campbell, Susan B., Leezenbaum, Nina B., Schmidt, Emily N., Day, Taylor N., & Brownell, Celia A. (2015). Concern for another’s distress in toddlers at high and low genetic risk for autism spectrum disorder. Journal of Autism and Developmental Disorders, 45(11), 3594–3605. doi:10.1007/s10803-015-2505-7CrossRefGoogle ScholarPubMed
Campbell, S. B., Moore, E. L., Northrup, J., & Brownell, C. A. (2017). Developmental changes in empathic concern and self-understanding in toddlers at genetic risk for autism spectrum disorder. Journal of Autism and Developmental Disorders, 47, 2690–2702. doi:10.1007/s10803-017-3192-3CrossRefGoogle ScholarPubMed
Cassel, T. D., Messinger, D. S., Ibanez, L. V., Haltigan, J. D., Acosta, S. I., & Buchman, A. C. (2007). Early social and emotional communication in the infant siblings of children with autism spectrum disorders: An examination of the broad phenotype. Journal of Autism and Developmental Disorders, 37, 122–132. doi:10.1007/s10803-006-0337-1CrossRefGoogle ScholarPubMed
Chawarska, K., Macari, S., Powell, K., DiNicola, L., & Shic, F. (2016). Enhanced social attention in female infant siblings at risk for autism. Journal of the American Academy of Child & Adolescent Psychiatry, 55, 188–195. doi:10.1016/j.jaac.2015.11.016CrossRefGoogle ScholarPubMed
Chawarska, K., Macari, S., & Shic, F. (2013). Decreased spontaneous attention to social scenes in 6-month-old infants later diagnosed with autism spectrum disorders. Biological Psychiatry, 74, 195–203. doi:10.1016/j.biopsych.2012.11.022CrossRefGoogle ScholarPubMed
Chen, F. S., & Yoon, J. M. D. (2011). Brief report: Broader autism phenotype predicts spontaneous reciprocity of direct gaze. Journal of Autism and Developmental Disorders, 41, 1131–1134. doi:10.1007/s10803-010-1136-2CrossRefGoogle ScholarPubMed
Chevallier, C., Kohls, G., Troiani, V., Brodkin, E. S., & Schultz, R. T. (2012). The social motivation theory of autism. Trends in Cognitive Sciences, 16, 231–239. doi:10.1016/j.tics.2012.02.007CrossRefGoogle ScholarPubMed
Compas, B., & Andreotti, C. (2013). Risk and resilience in child and adolescent psychology. In Beauchaine, T. P. & Hinshaw, S. P. (Eds.), Child and adolescent psychopathology (2nd ed., pp. 143–171). Hoboken, NJ: Wiley.Google Scholar
Compas, B. E., Champion, J. E., Forehand, R., Cole, D. A., Reeslund, K. L., Fear, J., & Roberts, L. (2010). Coping and parenting: Mediators of 12-month outcomes of a family group cognitive–behavioral preventive intervention with families of depressed parents. Journal of Consulting and Clinical Psychology, 78, 623–634. doi:10.1037/a0020459CrossRefGoogle ScholarPubMed
Constantino, J. N., & Charman, T. (2016). Diagnosis of autism spectrum disorder: Reconciling the syndrome, its diverse origins, and variation in expression. The Lancet Neurology, 15, 279–291. doi:10.1016/S1474-4422(15)00151-9CrossRefGoogle ScholarPubMed
Constantino, J. N., Davis, S. A., Todd, R. D., Schindler, M. K., Gross, M. M., Brophy, S. L., … Reich, W. (2003). Validation of a brief quantitative measure of autistic traits: Comparison of the Social Responsiveness Scale with the Autism Diagnostic Interview-Revised. Journal of Autism and Developmental Disorders, 33, 427–433. doi:10.1023/A:1025014929212CrossRefGoogle ScholarPubMed
Constantino, John N., Kennon-McGill, Stefanie, Weichselbaum, Claire, Marrus, Natasha, Haider, Alyzeh, Glowinski, Anne L., & Gillespie, Scott. (2017). Infant viewing of social scenes is under genetic control and is atypical in autism. Nature, 547(7663), 340–344. doi:10.1038/nature22999CrossRefGoogle ScholarPubMed
Cornew, L., Dobkins, K. R., Akshoomoff, N., McCleery, J. P., & Carver, L. J. (2012). Atypical social referencing in infant siblings of children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 42, 2611–2621. doi:10.1007/s10803-012-1518CrossRefGoogle ScholarPubMed
Crawford, H., Moss, J., Oliver, C., Elliott, N., Anderson, G. M., & McCleery, J. P. (2016). Visual preference for social stimuli in individuals with autism or neurodevelopmental disorders: An eye-tracking study. Molecular Autism, 7, 1–12. doi:10.1186/s13229-016-0084-xCrossRefGoogle ScholarPubMed
Crowell, S. E., Beauchaine, T. P., & Linehan, M. (2009). A biosocial developmental model of borderline personality: Elaborating and extending Linehan's theory. Psychological Bulletin, 135, 495–510. doi:10.1037/a0015616CrossRefGoogle ScholarPubMed
Curtin, S., & Vouloumanos, A. (2013). Speech preference is associated with autistic-like behavior in 18-months-olds at risk for autism spectrum disorder. Journal of Autism and Developmental Disorders, 43, 2114–2120. doi:10.1007/s10803-013-1759-1CrossRefGoogle ScholarPubMed
Cuthbert, B. N., & Insel, T. R. (2013). Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC Medicine, 11. doi:10.1186/1741-7015-11-126CrossRefGoogle ScholarPubMed
Dalton, K. M., Nacewicz, B. M., Alexander, A. L., & Davidson, R. J. (2007). Gaze-fixation, brain activation, and amygdala volume in unaffected siblings of individuals with autism. Biological Psychiatry, 61, 512–520. doi:10.1016/j.biopsych.2006.05.019CrossRefGoogle ScholarPubMed
Dawson, G., Rogers, S., Munson, J., Smith, M., Winter, J., Greenson, J., & Varley, J. (2010). Randomized, controlled trial of an intervention for toddlers with autism: The Early Start Denver Model. Pediatrics, 125, e17–e23.CrossRefGoogle ScholarPubMed
Dawson, G., Webb, S. J., Wijsman, E., Schellenberg, G., Estes, A., Munson, J., & Faja, S. (2005). Neurocognitive and electrophysiological evidence of altered face processing in parents of children with autism: Implications for a model of abnormal development of social brain circuitry in autism. Development and Psychopathology, 17, 679–697. doi:10.1017/S0025315405011604CrossRefGoogle Scholar
de Klerk, C. C. J. M., Gliga, T., Charman, T., & Johnson, M. H. (2014). Face engagement during infancy predicts later face recognition ability in younger siblings of children with autism. Developmental Science, 17, 596–611. doi:10.1111/desc.12141CrossRefGoogle ScholarPubMed
DeLaurentis, A. D. (2008). Emotion processing in typically developing infants and infant siblings of children with autism. [ProQuest Information & Learning]. In Dissertation Abstracts International: Section B: The Sciences and Engineering (Vol. 69, Issue 6–B, p. 3873).Google Scholar
Di Giorgio, E., Frasnelli, E., Rosa Salva, O., Maria Luisa, S., Puopolo, M., Tosoni, D., & Vallortigara, G. (2016). Difference in visual social predispositions between newborns at low- and high-risk for autism. Scientific Reports, 6, 26395–26395. doi:10.1038/srep26395CrossRefGoogle ScholarPubMed
Di Michele, V., Mazza, M., Cerbo, R., Roncone, R., & Casacchia, M. (2007). Deficits in pragmatic conversation as manifestation of genetic liability in autism. Clinical Neuropsychiatry: Journal of Treatment Evaluation, 4, 144–151.Google Scholar
Droucker, D., Curtin, S., & Vouloumanos, A. (2013). Linking infant-directed speech and face preferences to language outcomes in infants at risk for autism spectrum disorder. Journal of Speech, Language, and Hearing Research, 56, 567–576. doi:10.1044/1092-4388(2012/11-0266)CrossRefGoogle ScholarPubMed
Dundas, E., Gastgeb, H., & Strauss, M. S. (2012). Left visual field biases when infants process faces: A comparison of infants at high- and low-risk for autism spectrum disorder. Journal of Autism and Developmental Disorders, 42, 2659–2668. doi:10.1007/s10803-012-1523-yCrossRefGoogle ScholarPubMed
Dunnett, C. W. (1955). A multiple comparison procedure for comparing several treatments with a control. Journal of the American Statistical Association, 50, 1096–1121. doi:10.1080/01621459.1955.10501294CrossRefGoogle Scholar
Dykens, E., Hodapp, R., & Finucane, B. (2000). Genetics and mental retardation syndromes. Baltimore, MD: Paul Brooks Publishing.Google Scholar
Ecker, C. (2017). The neuroanatomy of autism spectrum disorder: An overview of structural neuroimaging findings and their translatability to the clinical setting. Autism, 21, 18–28. doi:10.1177/1362361315627136CrossRefGoogle ScholarPubMed
Edwards, L. A., Wagner, J. B., Tager-Flusberg, H., & Nelson, C. A. (2017). Differences in neural correlates of speech perception in 3 month olds at high and low risk for autism spectrum disorder. Journal of Autism and Developmental Disorders, 47, 3125–3138. doi:10.1007/s10803-017-3222-1CrossRefGoogle ScholarPubMed
Ellenbogen, M. A., Hodgins, S., Linnen, A.-M., & Ostiguy, C. S. (2011). Elevated daytime cortisol levels: A biomarker of subsequent major affective disorder? Journal of Affective Disorders, 132, 265–269. doi:10.1016/j.jad.2011.01.007CrossRefGoogle ScholarPubMed
Elsabbagh, M., Fernandes, J., Webb, S. J., Dawson, G., Charman, T., & Johnson, M. H. (2013). Disengagement of visual attention in infancy is associated with emerging autism in toddlerhood. Biological Psychiatry, 74, 189–194. doi:10.1016/j.biopsych.2012.11.030CrossRefGoogle ScholarPubMed
Elsabbagh, M., Mercure, E., Hudry, K., Chandler, S., Pasco, G., Charman, T., & Johnson, M. H. (2012). Infant neural sensitivity to dynamic eye gaze is associated with later emerging autism. Current Biology: CB, 22, 338–342. doi:10.1016/j.cub.2011.12.056CrossRefGoogle ScholarPubMed
Esposito, G., del Carmen Rostagno, M, Venuti, P., Haltigan, J. D., & Messinger, D. S. (2014). Brief report: Atypical expression of distress during the separation phase of the Strange Situation procedure in infant siblings at high risk for ASD. Journal of Autism and Developmental Disorders, 44, 975–980. doi:10.1007/s10803-013-1940-6CrossRefGoogle ScholarPubMed
Ewing, L., Pellicano, E., & Rhodes, G. (2013). Atypical updating of face representations with experience in children with autism. Developmental Science, 16, 116–123. doi:10.1111/desc.12007CrossRefGoogle ScholarPubMed
Eyler, L. T., Pierce, K., & Courchesne, E. (2012). A failure of left temporal cortex to specialize for language is an early emerging and fundamental property of autism. Brain: A Journal of Neurology, 135, 949–960. doi:10.1093/brain/awr364CrossRefGoogle ScholarPubMed
Faja, S., & Dawson, G. (2015). Reduced delay of gratification and effortful control among young children with autism spectrum disorders. Autism, 19, 91–101. doi:10.1177/1362361313512424.CrossRefGoogle ScholarPubMed
Ference, J., & Curtin, S. (2013). Attention to lexical stress and early vocabulary growth in 5-month-olds at risk for autism spectrum disorder. Journal of Experimental Child Psychology, 116, 891–903. doi:10.1016/j.jecp.2013.08.006CrossRefGoogle ScholarPubMed
Ference, J., & Curtin, S. (2015). The ability to map differentially stressed labels to objects predicts language development at 24 months in 12-month-olds at high risk for autism. Infancy, 20, 242–262. doi:10.1111/infa.12074CrossRefGoogle Scholar
Filipe, M. G., Frota, S., Castro, S. L., & Vicente, S. G. (2014). Atypical prosody in Asperger syndrome: Perceptual and acoustic measurements. Journal of Autism and Developmental Disorders, 44, 1972–1981. doi:10.1007/s10803-014-2073-2CrossRefGoogle ScholarPubMed
Filliter, J. H., Longard, J., Lawrence, M. A., Zwaigenbaum, L., Brian, J., Garon, N., … Bryson, S. E. (2015). Positive Affect in Infant Siblings of Children Diagnosed with Autism Spectrum Disorder. Journal of Abnormal Child Psychology, 43, 567–575. doi:10.1007/s10802-014-9921-6CrossRefGoogle ScholarPubMed
Finucane, B., Challman, T. D., Martin, C. L., & Ledbetter, D. H. (2016). Shift happens: Family background influences clinical variability in genetic neurodevelopmental disorders. Genetics in Medicine, 18, 302–304. doi:10.1038/gim.2015.92CrossRefGoogle ScholarPubMed
Fiorentini, C., Gray, L., Rhodes, G., Jeffery, L., & Pellicano, E. (2012). Reduced face identity aftereffects in relatives of children with autism. Neuropsychologia, 50, 2926–2932. doi:10.1016/j.neuropsychologia.2012.08.019CrossRefGoogle ScholarPubMed
Fischbach, G. D., & Lord, C. (2010). The Simons Simplex Collection: a resource for identification of autism genetic risk factors. Neuron, 68, 192–195. doi:10.1016/j.neuron.2010.10.006CrossRefGoogle ScholarPubMed
Foley, C. M. (2011). Autism-related deficits in theory of mind, central coherence and executive functions as predictors of social competency in a normal control sample [ProQuest Information & Learning]. In Dissertation Abstracts International: Section B: The Sciences and Engineering (Vol. 71, Issue 12-B, pp. 7722).Google Scholar
Fryer, S. L., Crocker, N. A., & Mattson, S. N. (2008). Exposure to teratogenic agents as a risk factor for psychopathology. In Beauchaine, T. P. & Hinshaw, S. P. (Eds.), Child and adolescent psychopathology (pp. 180–207). Hoboken, NJ: Wiley.Google Scholar
Fusaroli, R., Lambrechts, A., Bang, D., Bowler, D. M., & Gaigg, S. B. (2017). Is voice a marker for autism spectrum disorder? A systematic review and meta-analysis. Autism Research, 10, 384–407. doi:10.1002/aur.1678CrossRefGoogle Scholar
Gaigg, S. B., Cornell, A. S. F., & Bird, G. (2018). The psychophysiological mechanisms of alexithymia in autism spectrum disorder. Autism, 22, 227–231. doi:10.1177/1362361316667062CrossRefGoogle ScholarPubMed
Gangi, D. N., Ibañez, L. V., & Messinger, D. S. (2014). Joint attention initiation with and without positive affect: Risk group differences and associations with ASD symptoms. Journal of Autism and Developmental Disorders, 44, 1414–1424. doi:10.1007/s10803-013-2002-9CrossRefGoogle ScholarPubMed
Geschwind, D. H., Sowinski, J., Lord, C., Iversen, P., Shestack, J., Jones, P., & Spence, S. J. (2001). The autism genetic resource exchange: a resource for the study of autism and related neuropsychiatric conditions. The American Journal of Human Genetics, 69, 463–466. doi:10.1086/321292CrossRefGoogle Scholar
Gliga, T., Senju, A., Pettinato, M., Charman, T., & Johnson, M. H. (2014). Spontaneous belief attribution in younger siblings of children on the autism spectrum. Developmental Psychology, 50, 903–913. doi:10.1037/a0034146CrossRefGoogle ScholarPubMed
Gokcen, S., Bora, E., Erermis, S., Kesikci, H., & Aydin, C. (2009). Theory of mind and verbal working memory deficits in parents of autistic children. Psychiatry Research, 166, 46–53. doi:10.1016/j.psychres.2007.11.016CrossRefGoogle ScholarPubMed
Goldberg, W. A., Jarvis, K. L., Osann, K., Laulhere, T. M., Straub, C., Thomas, E., … Spence, M. A. (2005). Brief report: Early social communication behaviors in the younger siblings of children with autism. Journal of Autism and Developmental Disorders, 35, 657–664. doi:10.1007/s10803-005-0009-6CrossRefGoogle ScholarPubMed
Gottesman, I. I., & Gould, T. D. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. The American Journal of Psychiatry, 160, 636–645. doi:10.1176/appi.ajp.160.4.636CrossRefGoogle ScholarPubMed
Gottesman, I. I., & Shields, J. (1973). Genetic theorizing and schizophrenia. The British Journal of Psychiatry, 122, 15–30. doi:10.1192/bjp.122.1.15CrossRefGoogle Scholar
Gould, T. D., & Gottesman, I. I. (2006). Psychiatric endophenotypes and the development of valid animal models. Genes, Brain and Behavior, 5, 113–119. doi:10.1111/j.1601-183X.2005.00186.xCrossRefGoogle ScholarPubMed
Grant, K. E., Compas, B. E., Stuhlmacher, A. F., Thurm, A. E., McMahon, S. D., & Halpert, J. A. (2003). Stressors and child and adolescent psychopathology: Moving from markers to mechanisms of risk. Psychological Bulletin, 129, 447–466. doi:10.1037/0033-2909.129.3.447CrossRefGoogle ScholarPubMed
Gregory, B. L., & Plaisted-Grant, K. C. (2016). The autism-spectrum quotient and visual search: Shallow and deep autistic endophenotypes. Journal of Autism and Developmental Disorders, 46, 1503–1512. doi:10.1007/s10803-013-1951-3CrossRefGoogle ScholarPubMed
Griffin, C., Lombardo, M. V., & Auyeung, B. (2016). Alexithymia in children with and without autism spectrum disorders. Autism Research, 9, 773–780. doi:10.1002/aur.1569CrossRefGoogle ScholarPubMed
Guiraud, J. A., Kushnerenko, E., Tomalski, P., Davies, K., Ribeiro, H., & Johnson, M. H. (2011). Differential habituation to repeated sounds in infants at high risk for autism. NeuroReport: For Rapid Communication of Neuroscience Research, 22, 845–849.CrossRefGoogle ScholarPubMed
Guy, M. W., Richards, J. E., Tonnsen, B. L., & Roberts, J. E. (2018). Neural correlates of face processing in etiologically-distinct 12-month-old infants at high-risk of autism spectrum disorder. Developmental Cognitive Neuroscience, 29, 61–71. doi:10.1016/j.dcn.2017.03.002CrossRefGoogle ScholarPubMed
Hall, D., Huerta, M. F., McAuliffe, M. J., & Farber, G. K. (2012). Sharing heterogeneous data: the national database for autism research. Neuroinformatics, 10, 331–339. doi:10.1007/s12021-012-9151-4CrossRefGoogle ScholarPubMed
Haltigan, J. D., Ekas, N. V., Seifer, R., & Messinger, D. S. (2011). Brief report: Attachment security in infants at-risk for autism spectrum disorders. Journal of Autism and Developmental Disorders, 41, 962–967. doi:10.1007/s10803-010-1107-7CrossRefGoogle Scholar
Happé, F. G. E. (1995). The role of age and verbal ability in the theory of mind task performance of subjects with autism. Child Development, 66, 843–855. https://www.jstor.org/stable/1131954CrossRefGoogle ScholarPubMed
Hedley, D., Brewer, N., & Young, R. (2011). Face recognition performance of individuals with Asperger syndrome on the Cambridge face memory test. Autism Research, 4, 449–455. doi:10.1002/aur.214CrossRefGoogle ScholarPubMed
Herrington, J. D., Maddox, B. B., Kerns, C. M., Rump, K., Worley, J. A., Bush, J. C., … Miller, J. S. (2017). Amygdala volume differences in autism spectrum disorder are related to anxiety. Journal of Autism and Developmental Disorders, 47, 3682–3691. doi:10.1007/s10803-017-3206-1CrossRefGoogle ScholarPubMed
Hill, E., Berthoz, S., & Frith, U. (2004). Brief report: Cognitive processing of own emotions in individuals with autism: EBSCOhost. Journal of Autism and Developmental Disorders, 34, 229.CrossRefGoogle Scholar
Holt, R. J., Chura, L. R., Lai, M., Suckling, J., von dem Hagen, E., Calder, A. J., … Spencer, M. D. (2014). ‘Reading the mind in the eyes': An fMRI study of adolescents with autism and their siblings. Psychological Medicine, 44, 3215–3227. doi:10.1017/S0033291714000233CrossRefGoogle ScholarPubMed
Hoyt, W. T., & Kerns, M. D. (1999). Magnitude and moderators of bias in observer ratings: A meta-analysis. Psychological Methods, 4, 403–424. doi:10.1037/1082-989X.4.4.403CrossRefGoogle Scholar
Hutman, T., Rozga, A., DeLaurentis, A. D., Barnwell, J. M., Sugar, C. A., & Sigman, M. (2010). Response to distress in infants at risk for autism: A prospective longitudinal study. Journal of Child Psychology and Psychiatry, 51, 1010–1020. doi:10.1111/j.1469-7610.2010.02270.xCrossRefGoogle ScholarPubMed
Iacono, W. G., Malone, S. M., & Vrieze, S. I. (2017). Endophenotype best practices. International Journal of Psychophysiology, 111, 115–144. doi:10.1016/j.ijpsycho.2016.07.516CrossRefGoogle ScholarPubMed
Ibañez, L. V., Grantz, C. J., & Messinger, D. S. (2013). The development of referential communication and autism symptomatology in high-risk infants. Infancy, 18, 687–707. doi:10.1111/j.1532-7078.2012.00142.xCrossRefGoogle ScholarPubMed
Insel, T. R., & Cuthbert, B. N. (2009). Endophenotypes: Bridging genomic complexity and disorder heterogeneity. Biological Psychiatry, 66, 988–989. doi:10.1016/j.biopsych.2009.10.008CrossRefGoogle ScholarPubMed
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., … Wang, P. (2010). Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. The American Journal of Psychiatry, 167, 748–751. doi:10.1176/.CrossRefGoogle Scholar
Jack, A., & Pelphrey, K. A. (2017). Annual research review: Understudied populations within the autism spectrum – Current trends and future directions in neuroimaging research. Journal of Child Psychology and Psychiatry, 58, 411–435. doi:10.1111/jcpp.12687CrossRefGoogle ScholarPubMed
John, B., & Lewis, K. R. (1966). Chromosome variability and geographical distribution in insects. Science, 152, 711–721. doi:10.1126/science.152.3723.711CrossRefGoogle Scholar
Jones, W., Carr, K., & Klin, A. (2008). Absence of preferential looking to the eyes of approaching adults predicts level of social disability in 2-year-old toddlers with autism spectrum disorder. Archives of General.CrossRefGoogle Scholar
Jones, E. J. H., Venema, K., Earl, R., Lowy, R., Barnes, K., Estes, A., … Webb, S. J. (2016). Reduced engagement with social stimuli in 6-month-old infants with later autism spectrum disorder: A longitudinal prospective study of infants at high familial risk. Journal of Neurodevelopmental Disorders, 8, 1–20. doi:10.1186/s11689-016-9139-8CrossRefGoogle ScholarPubMed
Jones, E. J. H., Venema, K., Earl, R. K., Lowy, R., & Webb, S. J. (2017). Infant social attention: An endophenotype of ASD-related traits? Journal of Child Psychology and Psychiatry, and Allied Disciplines, 58, 270–281. doi:10.1111/jcpp.12650CrossRefGoogle ScholarPubMed
Kaiser, M. D., Hudac, C. M., Shultz, S., Lee, S. M., Cheung, C., Berken, A. M., … Pelphrey, K. A. (2010). Neural signatures of autism. Proceedings of the National Academy of Sciences, 107, 21223–21228. doi:10.1073/pnas.1010412107CrossRefGoogle ScholarPubMed
Kaiser, M. D., & Pelphrey, K. A. (2012). Disrupted action perception in autism: Behavioral evidence, neuroendophenotypes, and diagnostic utility. Developmental Cognitive Neuroscience, 2, 25–35. doi:10.1016/j.dcn.2011.05.005CrossRefGoogle ScholarPubMed
Kalsner, L., Twachtman-Bassett, J., Derynioski, L., & Chamberlain, S. (2018). Yield of genetic testing including targeted gene panel in a clinical population of children with autism spectrum disorder. Neurology, 90, P1.303.Google Scholar
Key, A. P., Ibanez, L. V., Henderson, H. A., Warren, Z., Messinger, D. S., & Stone, W. L. (2015). Positive affect processing and joint attention in infants at high risk for autism: An exploratory study. Journal of Autism and Developmental Disorders, 45, 4051–4062. doi:10.1007/s10803-014-2191-xCrossRefGoogle Scholar
Key, A. P. F., & Stone, W. L. (2012). Same but different: 9-month-old infants at average and high risk for autism look at the same facial features but process them using different brain mechanisms. Autism Research, 5, 253–266. doi:10.1002/aur.1231CrossRefGoogle Scholar
Kimhi, Y. (2014). Theory of mind abilities and deficits in autism spectrum disorders. Topics in Language Disorders, 34, 329–343. doi:10.1097/TLD.0000000000000033CrossRefGoogle Scholar
Kozak, M. J., & Cuthbert, B. N. (2016). The NIMH research domain criteria initiative: Background, issues, and pragmatics. Psychophysiology, 53, 286–297. doi:10.1111/psyp.12518CrossRefGoogle ScholarPubMed
Lambert-Brown, B., McDonald, N. M., Mattson, W. I., Martin, K. B., Ibañez, L. V., Stone, W. L., & Messinger, D. S. (2015). Positive emotional engagement and autism risk. Developmental Psychology, 51, 848–855. doi:10.1037/a0039182CrossRefGoogle ScholarPubMed
Landa, R., Piven, J., Wzorek, M. M., Gayle, J. O., Chase, G. A., & Folstein, S. E. (1992). Social language use in parents of autistic individuals. Psychological Medicine, 22, 245–254. doi:10.1017/s0033291700032918CrossRefGoogle ScholarPubMed
Lenzenweger, M. (2013). Thinking clearly about the endophenotype-intermediate phenotype- biomarker distinctions in developmental psychopathology research. Developmental Psychopathology, 25, 1347–1357. doi:10.1017/S0954579413000655CrossRefGoogle ScholarPubMed
Libero, L. E., DeRamus, T. P., Deshpande, H. D., & Kana, R. K. (2014). Surface-based morphometry of the cortical architecture of autism spectrum disorders: Volume, thickness, area, and gyrification. Neuropsychologia, 62, 1–10. doi:10.1016/j.neuropsychologia.2014.07.001CrossRefGoogle ScholarPubMed
Lloyd-Fox, S., Blasi, A., Elwell, C. E., Charman, T., Murphy, D., & Johnson, M. H. (2013). Reduced neural sensitivity to social stimuli in infants at risk for autism. Proceedings of the Royal Society B: Biological Sciences, 280, 20123026. doi:10.1098/rspb.2012.3026CrossRefGoogle ScholarPubMed
Lord, C., Luyster, R., Gotham, K., & Guthrie, W. (2012). Autism diagnostic observation schedule, 2nd edition (ADOS-2) Manual (Part II): Toddler module. Torrance, CA: Western Psychological Services.Google Scholar
Losh, M., & Piven, J. (2007). Social-cognition and the broad autism phenotype: Identifying genetically meaningful phenotypes. Journal of Child Psychology and Psychiatry, 48, 105–112. doi:10.1111/j.1469-7610.2006.01594.xCrossRefGoogle ScholarPubMed
Luyster, R., Gotham, K., Guthrie, W., Coffing, M., Petrak, R., Pierce, K., & Lord, C. (2009). The Autism Diagnostic Observation Schedule – Toddler Module: A new module of a standardized diagnostic measure for autism spectrum disorders. Journal of Autism and Developmental Disorders, 39, 1305–1320. doi:10.1007/s10803-009-0746-zCrossRefGoogle ScholarPubMed
Luyster, R. J., Powell, C., Tager-Flusberg, H., & Nelson, C. A. (2014). Neural measures of social attention across the first years of life: Characterizing typical development and markers of autism risk. Developmental Cognitive Neuroscience, 8, 131–143. doi:10.1016/j.dcn.2013.09.006CrossRefGoogle ScholarPubMed
Luyster, R. J., Wagner, J. B., Vogel-Farley, V., Tager-Flusberg, H., & Nelson, C. A. I. II (2011). Neural correlates of familiar and unfamiliar face processing in infants at risk for autism spectrum disorders. Brain Topography, 24, 220–228. doi:10.1007/s10548-011-0176-zCrossRefGoogle ScholarPubMed
Masten, A. S. (2014). Global perspectives on resilience in children and youth. Child Development, 85, 6–20. doi.org/10.1111/cdev.12205CrossRefGoogle ScholarPubMed
McCleery, J. P., Akshoomoff, N., Dobkins, K. R., & Carver, L. J. (2009). Atypical face versus object processing and hemispheric asymmetries in 10-month-old infants at risk for autism. Biological Psychiatry, 66, 950–957. doi:10.1016/j.biopsych.2009.07.031CrossRefGoogle ScholarPubMed
McDonald, N. M., Murphy, H. G., & Messinger, D. S. (2017). Empathic responding in preschool-aged children with familial risk for autism. Autism Research, 10, 1621–1628. doi:10.1002/aur.1819CrossRefGoogle ScholarPubMed
McLean, L. (2009). The relation between early joint attention responding and later theory of mind in younger siblings of children with autism (Honors thesis, Vanderbilt University Institutional Repository. https://ir.vanderbilt.edu/handle/1803/2964Google Scholar
Mehler, J., Jusczyk, P., Lambertz, G., Halsted, N., Bertoncini, J., & Amiel-Tison, C. (1988). A precursor of language acquisition in young infants. Cognition, 29, 143–178. doi:10.1016/0010-0277(88)90035-2CrossRefGoogle ScholarPubMed
Merin, N., Young, G. S., Ozonoff, S., & Rogers, S. J. (2007). Visual fixation patterns during reciprocal social interaction distinguish a subgroup of 6-month-old infants at-risk for autism from comparison infants. Journal of Autism and Developmental Disorders, 37, 108–121. doi:10.1007/s10803-006-0342-4CrossRefGoogle ScholarPubMed
Messinger, D., Young, G. S., Ozonoff, S., Dobkins, K., Carter, A., Zwaigenbaum, L., & Landa, R. J. (2013). Beyond autism: A baby siblings research consortium study of high-risk children at three years of age. Journal of the American Academy of Child & Adolescent Psychiatry, 52(3), 300–308.e1. doi:10.1016/j.jaac.2012.12.011CrossRefGoogle Scholar
Miller, M., Iosif, A. M., Hill, M., Young, G. S., Schwichtenberg, A. J., & Ozonoff, S. (2017). Response to name in infants developing autism spectrum disorder: A prospective study. Journal of Pediatrics, 183, 141–146.e1. doi:10.1016/j.jpeds.2016.12.071CrossRefGoogle ScholarPubMed
Miu, A. C., Pană, S. E., & Avram, J. (2012). Emotional face processing in neurotypicals with autistic traits: Implications for the broad autism phenotype. Psychiatry Research, 198, 489–494. doi:10.1016/j.psychres.2012.01.024CrossRefGoogle ScholarPubMed
Morris, S., & Cuthbert, B. (2012). Research Domain Criteria: cognitive systems, neural circuits, and dimensions of behavior. Dialogues in Clinical Neuroscience, 14, 29–37.Google ScholarPubMed
Mundy, P. (2018). A review of joint attention and social-cognitive brain systems in typical development and autism spectrum disorder. European Journal of Neuroscience, 47, 497–514. doi:10.1111/ejn.13720CrossRefGoogle ScholarPubMed
Mundy, P., Sigman, M., & Kasari, C. (1994). Joint attention, developmental level, and symptom presentation in autism. Development and Psychopathology, 6, 389–401. doi:10.1017/S0954579400006003CrossRefGoogle Scholar
Nadig, A. S., Ozonoff, S., Young, G. S., Rozga, A., Sigman, M., & Rogers, S. J. (2007). A prospective study of response to name in infants at risk for autism. Archives of Pediatrics and Adolescent Medicine, 161, 378–383. doi:10.1001/archpedi.161.4.378CrossRefGoogle ScholarPubMed
Nadig, A., & Shaw, H. (2012). Acoustic and perceptual measurement of expressive prosody in high-functioning autism: Increased pitch range and what it means to listeners. Journal of Autism and Developmental Disorders, 42, 499–511. doi:10.1007/s10803-011-1264-3CrossRefGoogle ScholarPubMed
National Institute of Mental Health (2019). RDoC matrix. Retrieved from https://www.nimh.nih.gov/research/research-funded-by-nimh/rdoc/constructs/rdoc-matrix.shtmlGoogle Scholar
Nele, D., Ellen, D., Petra, W., & Herbert, R. (2015). Social information processing in infants at risk for ASD at 5 months of age: The influence of a familiar face and direct gaze on attention allocation. Research in Autism Spectrum Disorders, 17, 95–105. doi:10.1016/j.rasd.2015.06.006CrossRefGoogle Scholar
Nichols, C. M., Ibañez, L. V., Foss-Feig, J., & Stone, W. L. (2014). Social smiling and its components in high-risk infant siblings without later ASD symptomatology. Journal of Autism and Developmental Disorders, 44, 894–902. doi:10.1007/s10803-013-1944-2CrossRefGoogle ScholarPubMed
Noland, J. S., Reznick, J. S., Stone, W. L., Walden, T., & Sheridan, E. H. (2010). Better working memory for non-social targets in infant siblings of children with autism spectrum disorder. Developmental Science, 13, 244–251. doi:10.1111/j.1467-7687.2009.00882.xCrossRefGoogle ScholarPubMed
Northoff, G., & Tumati, S. (2019). “Average is good, extremes are bad” – Non-linear inverted U-shaped relationship between neural mechanisms and functionality of mental features. Neuroscience & Biobehavioral Reviews, 104, 11–25. doi:10.1016/j.neubiorev.2019.06.030CrossRefGoogle ScholarPubMed
Oerlemans, A. M., Droste, K., Van Steijn, D. J., De Sonneville, L. M. J., Buitelaar, J. K., & Rommelse, N. N. J. (2013). Co-segregation of social cognition, executive function and local processing style in children with ASD, their siblings and normal controls. Journal of Autism and Developmental Disorders, 43, 2764–2778. doi:10.1007/s10803-013-1807-xCrossRefGoogle ScholarPubMed
Oerlemans, A. M., van der Meer, J. M. J., van Steijn, D. J., de Ruiter, S. W., de Bruijn, Y. G. E., de Sonneville, L. M. J., … Rommelse, N. N. J. (2014). Recognition of facial emotion and affective prosody in children with ASD (+ADHD) and their unaffected siblings. European Child & Adolescent Psychiatry, 23, 257–271. doi:10.1007/s00787-013-0446-2Google ScholarPubMed
Ozonoff, S., losif, A., Baguio, F., Cook, I. C., Hill, M. M., Hutman, T., & Young, G. S. (2010). A prospective study of the emergence of early behavioral signs of autism. Journal of the American Academy of Child & Adolescent Psychiatry, 49, 256–266. doi:10.1097/00004583-201003000-00009Google ScholarPubMed
Oztan, O., Jackson, L. P., Libove, R. A., Sumiyoshi, R. D., Phillips, J. M., Garner, J. P., & Parker, K. J. (2018). Biomarker discovery for disease status and symptom severity in children with autism. Psychoneuroendocrinology, 89, 39–45. doi:10.1016/j.psyneuen.2017.12.022CrossRefGoogle ScholarPubMed
Palermo, M. T., Pasqualetti, P., Barbati, G., Intelligente, F., & Rossini, M. P. (2006). Recognition of schematic facial displays of emotion in parents of children with autism. Autism, 10, 353–364. doi:10.1177/1362361306064431CrossRefGoogle ScholarPubMed
Parker, K. J., Garner, J. P., Libove, R. A., Hyde, S. A., Hornbeak, K. B., Carson, D. S., … Hardan, A. Y. (2014). Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder. PNAS Proceedings of the National Academy of Sciences of the United States of America, 111, 12258–12263. doi:10.1073/pnas.1402236111CrossRefGoogle ScholarPubMed
Patriquin, M. A., DeRamus, T., Libero, L. E., Laird, A., & Kana, R. K. (2016). Neuroanatomical and neurofunctional markers of social cognition in autism spectrum disorder. Human Brain Mapping, 37, 3957–3978. doi:10.1002/hbm.23288CrossRefGoogle ScholarPubMed
Paul, R., Fuerst, Y., Ramsay, G., Chawarska, K., & Klin, A. (2011). Out of the mouths of babes: Vocal production in infant siblings of children with ASD. Journal of Child Psychology and Psychiatry, 52, 588–598. doi:10.1111/j.1469-7610.2010.02332.xCrossRefGoogle ScholarPubMed
Perdue, K. L., Edwards, L. A., Tager-Flusberg, H., & Nelson, C. A. (2017). Differing developmental trajectories in heart rate responses to speech stimuli in infants at high and low risk for autism spectrum disorder. Journal of Autism and Developmental Disorders, 47, 2434–2442. doi:10.1007/s10803-017-3167-4CrossRefGoogle ScholarPubMed
Pierce, K., Marinero, S., Hazin, R., McKenna, B., Barnes, C. C., & Malige, A. (2016). Eye tracking reveals abnormal visual preference for geometric images as an early biomarker of an autism spectrum disorder subtype associated with increased symptom severity. Biological Psychiatry, 79, 657–666. doi:10.1016/j.biopsych.2015.03.032CrossRefGoogle ScholarPubMed
Pierce, K., Müller, R., Ambrose, J., Allen, G., & Courchesne, E. (2001). Face processing occurs outside the fusiform ‘face area’ in autism: Evidence from functional MRI. Brain: A Journal of Neurology, 124, 2059–2073. doi:10.1093/brain/124.10.2059CrossRefGoogle ScholarPubMed
Plomin, R. (2005). Finding genes in child psychology and psychiatry: When are we going to be there? Journal of Child Psychology and Psychiatry, 46, 1030–1038. doi:10.1111/j.1469-7610.2005.01524.xCrossRefGoogle Scholar
Presmanes, A. G., Walden, T. A., Stone, W. L., & Yoder, P. J. (2007). Effects of different attentional cues on responding to joint attention in younger siblings of children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 37, 133–144. doi:10.1007/s10803-006-0338-0CrossRefGoogle ScholarPubMed
Quigley, J., McNally, S., & Lawson, S. (2016). Prosodic patterns in interaction of low-risk and at-risk-of-autism spectrum disorders infants and their mothers at 12 and 18 months. Language Learning and Development, 12, 295–310. doi:10.1080/15475441.2015.1075405CrossRefGoogle Scholar
Redcay, E., & Courchesne, E. (2008). Deviant functional magnetic resonance imaging patterns of brain activity to speech in 2-3-year-old children with autism spectrum disorder. Biological Psychiatry, 64, 589–598. doi:10.1016/j.biopsych.2008.05.020CrossRefGoogle ScholarPubMed
Rhodes, G., Ewing, L., Jeffery, L., Avard, E., & Taylor, L. (2014). Reduced adaptability, but no fundamental disruption, of norm-based face-coding mechanisms in cognitively able children and adolescents with autism. Neuropsychologia, 62, 262–268. doi:10.1016/j.neuropsychologia.2014.07.030CrossRefGoogle ScholarPubMed
Rhodes, G., Jeffery, L., Taylor, L., & Ewing, L. (2013). Autistic traits are linked to reduced adaptive coding of face identity and selectively poorer face recognition in men but not women. Neuropsychologia, 51, 2702–2708. doi:10.1016/j.neuropsychologia.2013.08.016CrossRefGoogle Scholar
Riina, E. M., Martin, A., & Brooks-Gunn, J. (2014). Parent-to-child physical aggression, neighborhood cohesion, and development of children's internalizing and externalizing. Journal of Applied Developmental Psychology, 35, 468–477. doi:10.1016/j.appdev.2014.04.005CrossRefGoogle Scholar
Rozga, A., Hutman, T., Young, G. S., Rogers, S. J., Ozonoff, S., Dapretto, M., & Sigman, M. (2011). Behavioral profiles of affected and unaffected siblings of children with autism: Contribution of measures of mother-infant interaction and nonverbal communication. Journal of Autism and Developmental Disorders, 41, 287–301. doi:10.1007/s10803-010-1051-6CrossRefGoogle ScholarPubMed
Ruggeri, B., Sarkans, U., Schumann, G., & Persico, A. M. (2014). Biomarkers in autism spectrum disorder: The old and the new. Psychopharmacology, 231, 1201–1216. doi:10.1007/s00213-013-3290-7CrossRefGoogle ScholarPubMed
Ruser, T. F., Arin, D., Dowd, M., Putnam, S., Winklosky, B., Rosen-Sheidley, B., … Folstein, S. (2007). Communicative competence in parents of children with autism and parents of children with specific language impairment. Journal of Autism and Developmental Disorders, 37, 1323–1336. doi:10.1007/s10803-006-0274-zCrossRefGoogle ScholarPubMed
Rutgers, A. H., Bakermans-Kranenburg, M. J., van IJzendoorn, M. H., & van Berckelaer-Onnes, I. A. (2004). Autism and attachment: A meta-analytic review. Journal of Child Psychology and Psychiatry, 45, 1123–1134. doi:10.1111/j.1469-7610.2004.t01-1-00305.xCrossRefGoogle ScholarPubMed
Rutherford, M.D. (2013). Social Attention is Measurably and Increasingly Atypical Across the First Six Months in the Broader Autism Phenotype. Journal of Psychology & Psychotherapy, 03(04). doi:10.4172/2161-0487Google Scholar
Rutherford, M. D., Walsh, J. A., & Lee, V. (2015). Brief report: Infants developing with ASD show a unique developmental pattern of facial feature scanning. Journal of Autism and Developmental Disorders, 45, 2618–2623. doi:10.1007/s10803-015-2396-7CrossRefGoogle ScholarPubMed
Sato, W., Kochiyama, T., Uono, S., Yoshimura, S., Kubota, Y., Sawada, R., … Toichi, M. (2017). Reduced gray matter volume in the social brain network in adults with autism spectrum disorder. Frontiers in Human Neuroscience, 11, 395. doi:10.3389/fnhum.2017.00395CrossRefGoogle ScholarPubMed
Schoen, E., Paul, R., & Chawarska, K. (2011). Phonology and vocal behavior in toddlers with autism spectrum disorders. Autism Research, 4, 177–188. doi:10.1002/aur.183CrossRefGoogle ScholarPubMed
Seery, A. M. (2015). Electrophysiological indices of language processing in infants at risk for ASD. [ProQuest Information & Learning]. In Electrophysiological indices of language processing in infants at risk for ASD (Vol. 75, Issue 12B(E)).Google Scholar
Seery, A. M., Vogel-Farley, V., Tager-Flusberg, H., & Nelson, C. A. (2013). Atypical lateralization of ERP response to native and non-native speech in infants at risk for autism spectrum disorder. Developmental Cognitive Neuroscience, 5, 10–24. doi:10.1016/j.dcn.2012.11.007CrossRefGoogle ScholarPubMed
Seltzer, M. M., Abbeduto, L., Krauss, M. W., Greenberg, J., & Swe, A. (2004). Comparison groups in autism family research: Down syndrome, Fragile X syndrome, and schizophrenia. Journal of Autism and Developmental Disorders, 34, 41–47. doi:10.1023/B:JADD.0000018073.92982.64CrossRefGoogle Scholar
Sheinkopf, S. J., Iverson, J. M., Rinaldi, M. L., & Lester, B. M. (2012). Atypical cry acoustics in 6-month-old infants at risk for autism spectrum disorder. Autism Research, 5, 331–339. doi:10.1002/aur.1244CrossRefGoogle ScholarPubMed
Sigman, M., & Mundy, P. (1989). Social attachments in autistic children. Journal of the American Academy of Child & Adolescent Psychiatry, 28, 74–81. doi:10.1097/00004583-198901000-00014CrossRefGoogle ScholarPubMed
Sigman, M., & Ungerer, J. A. (1984). Attachment behaviors in autistic children. Journal of Autism and Developmental Disorders, 14, 231–244. doi:10.1007/BF02409576CrossRefGoogle ScholarPubMed
Spencer, M. D., Holt, R. J., Chura, L. R., Suckling, J., Calder, A. J., Bullmore, E. T., & Baron-Cohen, S. (2011). A novel functional brain imaging endophenotype of autism: The neural response to facial expression of emotion. Translational Psychiatry, 1, e19. doi:10.1038/tp.2011.18CrossRefGoogle ScholarPubMed
Stanfield, A. C., McIntosh, A. M., Spencer, M. D., Philip, R., Gaur, S., & Lawrie, S. M. (2008). Towards a neuroanatomy of autism: A systematic review and meta-analysis of structural magnetic resonance imaging studies. European Psychiatry, 23, 289–299. doi:10.1016/j.eurpsy.2007.05.00CrossRefGoogle ScholarPubMed
Stone, W., McMahon, C., Yoder, P., & Walden, T. (2007). Early social-communicative and cognitive development of younger siblings of children with autism spectrum disorders. Archives of Pediatrics and Adolescent Medicine, 161, 384–390. doi:10.1001/archpedi.161.4.384CrossRefGoogle ScholarPubMed
Sucksmith, E., Allison, C., Baron-Cohen, S., Chakrabarti, B., & Hoekstra, R. A. (2013). Empathy and emotion recognition in people with autism, first-degree relatives, and controls. Neuropsychologia, 51, 98–105. doi:10.1016/j.neuropsychologia.2012.11.013CrossRefGoogle ScholarPubMed
Sullivan, M., Finelli, J., Marvin, A., Garrett-Mayer, E., Bauman, M., & Landa, R. (2007). Response to joint attention in toddlers at risk for autism spectrum disorder: A prospective study. Journal of Autism and Developmental Disorders, 37, 37–48. doi:10.1007/s10803-006-0335-3CrossRefGoogle ScholarPubMed
Swanson, M. R., Serlin, G. C., & Siller, M. (2013). Broad autism phenotype in typically developing children predicts performance on an eye-tracking measure of joint attention. Journal of Autism and Developmental Disorders, 43, 707–718. doi:10.1007/s10803-012-1616-7CrossRefGoogle Scholar
Szatmari, P., Georgiades, S., Duku, E., Zwaigenbaum, L., Goldberg, J., & Bennett, T. (2008). Alexithymia in parents of children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 38, 1859–1865. doi:10.1007/s10803-008-0576-4CrossRefGoogle ScholarPubMed
Tajmirriyahi, M., Nejati, V., Pouretemad, H., & Sepehr, R. M. (2013). Reading the mind in the face and voice in parents of children with autism spectrum disorders. Research in Autism Spectrum Disorders, 7, 1543–1550. doi:10.1016/j.rasd.2013.08.007CrossRefGoogle Scholar
Tammimies, K., Marshall, C., Walker, S., Kaur, G., Thiruvahindrapuram, B., Lionel, A., … Fernandez, B. (2015). Molecular diagnostic yield of chromosomal microarray analysis and whole-exome sequencing in children with autism spectrum disorder. Journal of the American Medical Association, 314, 895–903.CrossRefGoogle ScholarPubMed
Teague, S. J., Gray, K. M., Tonge, B. J., & Newman, L. K. (2017). Attachment in children with autism spectrum disorder: A systematic review. Research in Autism Spectrum Disorders, 35, 35–50. doi:10.1016/j.rasd.2016.12.002CrossRefGoogle Scholar
Thorup, E., Nyström, P., Gredebäck, G., Bölte, S., & Falck-Ytter, T. (2018). Reduced alternating gaze during social interaction in infancy is associated with elevated symptoms of autism in toddlerhood. Journal of Abnormal Child Psychology, 46, 1547–1561. doi:10.1007/s10802-017-0388-0CrossRefGoogle ScholarPubMed
Viding, E., & Blakemore, S. (2007). Endophenotype approach to developmental psychopathology: Implications for autism research. Behavior Genetics, 37, 51–60. doi:10.1007/s10519-006-9105-4CrossRefGoogle ScholarPubMed
Vouloumanos, A., & Werker, J. F. (2009). Infants’ learning of novel words in a stochastic environment. Developmental Psychology, 45, 1611–1617. doi:10.1037/a0016134CrossRefGoogle Scholar
Wagner, Jennifer B., Luyster, Rhiannon J., Moustapha, Hana, Tager-Flusberg, Helen, & Nelson, Charles Alexander. (2017). Differential attention to faces in infant siblings of children with autism spectrum disorder and associations with later social and language ability. International Journal of Behavioral Development, 42(1), 83–92. doi:10.1177/0165025416673475CrossRefGoogle Scholar
Wagner, J. B., Luyster, R. J., Tager-Flusberg, H., & Nelson, C. A. (2016). Greater pupil size in response to emotional faces as an early marker of social-communicative difficulties in infants at high risk for autism. Infancy, 21, 560–581. doi:10.1111/infa.12128CrossRefGoogle ScholarPubMed
Wallace, S., Sebastian, C., Pellicano, E., Parr, J., & Bailey, A. (2010). Face processing abilities in relatives of individuals with ASD. Autism Research, 3, 345–349. doi:10.1002/aur.161CrossRefGoogle ScholarPubMed
Walsh, J. A., Maurer, D., Vida, M. D., Rhodes, G., Jeffery, L., & Rutherford, M. D. (2015). Norm-based coding of facial identity in adults with autism spectrum disorder. Vision Research, 108, 33–40. doi:10.1016/j.visres.2014.11.018CrossRefGoogle ScholarPubMed
Webb, S. J., Jones, E. J. H., Merkle, K., Namkung, J., Toth, K., Greenson, J., & Dawson, G. (2010). Toddlers with elevated autism symptoms show slowed habituation to faces. Child Neuropsychology: A Journal on Normal and Abnormal Development in Childhood and Adolescence, 16, 255–278. doi:10.1080/09297041003601454CrossRefGoogle ScholarPubMed
Weigelt, S., Koldewyn, K., & Kanwisher, N. (2012). Face identity recognition in autism spectrum disorders: A review of behavioral studies. Neuroscience & Biobehavioral Reviews, 36, 1060–1084. doi:10.1016/j.neubiorev.2011.12.008CrossRefGoogle ScholarPubMed
Wessman, J., Paunio, T., Tuulio-Henriksson, A., Koivisto, M., Partonen, T., Suvisaari, J., … Peltonen, L. (2009). Mixture model clustering of phenotype features reveals evidence for association of DTNBP1 to a specific subtype of schizophrenia. Biological Psychiatry, 66, 990–996. doi:10.1016/j.biopsych.2009.05.034CrossRefGoogle ScholarPubMed
Winder, B. M., Wozniak, R. H., Parladé, M. V., & Iverson, J. M. (2013). Spontaneous initiation of communication in infants at low and heightened risk for autism spectrum disorders. Developmental Psychology, 49, 1931–1942. doi:10.1037/a0031061CrossRefGoogle ScholarPubMed
Woodbury-Smith, M. R., Robinson, J., Wheelwright, S., & Baron-Cohen, S. (2005). Screening adults for Asperger syndrome using the AQ: A preliminary study of its diagnostic validity in clinical practice. Journal of Autism and Developmental Disorders, 35, 331–335. doi:10.1007/s10803-005-3300-7CrossRefGoogle ScholarPubMed
World Health Organization. (2004). ICD-10: International statistical classification of diseases and related health problems. Tenth revision (2nd ed.). Geneva: World Health Organization. https://apps.who.int/iris/handle/10665/42980.Google Scholar
Wright, A. G. C., Krueger, R. F., Hobbs, M. J., Markon, K. E., Eaton, N. R., & Slade, T. (2013). The structure of psychopathology: Toward an expanded quantitative empirical model. Journal of Abnormal Psychology, 122, 281–294. doi:10.1037/a0030133CrossRefGoogle ScholarPubMed
Yirmiya, N., Gamliel, I., Pilowsky, T., Feldman, R., Baron-Cohen, S., & Sigman, M. (2006). The development of siblings of children with autism at 4 and 14 months: Social engagement, communication, and cognition. Journal of Child Psychology and Psychiatry, 47, 511–523. doi:10.1111/j.1469-7610.2005.01528.xCrossRefGoogle ScholarPubMed
Yoder, P., Stone, W. L., Walden, T., & Malesa, E. (2009). Predicting social impairment and ASD diagnosis in younger siblings of children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 39, 1381–1391. doi:10.1007/s10803-009-0753-0CrossRefGoogle ScholarPubMed
Young, G. S., Merin, N., Rogers, S. J., & Ozonoff, S. (2009). Gaze behavior and affect at 6 months: Predicting clinical outcomes and language development in typically developing infants and infants at risk for autism. Developmental Science, 12, 798–814. doi:10.1111/j.1467-7687.2009.00833.xCrossRefGoogle ScholarPubMed
Yucel, G. H., Belger, A., Bizzell, J., Parlier, M., Adolphs, R., & Piven, J. (2015). Abnormal neural activation to faces in the parents of children with autism. Cerebral Cortex, 25, 4653–4666. doi:10.1093/cercor/bhu147CrossRefGoogle ScholarPubMed
Zelazo, P. D., & Carlson, S. M. (2012). Hot and cool executive function in childhood and adolescence: Development and plasticity. Child Development Perspectives, 6, 354–360. doi:10.1111/j.1750-8606.2012.00246.xGoogle Scholar
Zwaigenbaum, L., Bryson, S., Rogers, T., Roberts, W., Brian, J., & Szatmari, P. (2005). Behavioral manifestations of autism in the first year of life. International Journal of Developmental Neuroscience, 23, 143–152. doi:10.1016/j.ijdevneu.2004.05.001CrossRefGoogle ScholarPubMed
Supplementary material: File

Tiede and Walton supplementary material

Tiede and Walton supplementary material 1

Download Tiede and Walton supplementary material(File)
File 14.7 KB
Supplementary material: File

Tiede and Walton supplementary material

Tiede and Walton supplementary material 2

Download Tiede and Walton supplementary material(File)
File 76.3 KB