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Suicide ideation among high-risk adolescent females: Examining the interplay between parasympathetic regulation and friendship support

  • Matteo Giletta (a1), Paul D. Hastings (a2), Karen D. Rudolph (a3), Daniel J. Bauer (a4), Matthew K. Nock (a5) and Mitchell J. Prinstein (a4)...
Abstract

Poor physiological self-regulation has been proposed as a potential biological vulnerability for adolescent suicidality. This study tested this hypothesis by examining the effect of parasympathetic stress responses on future suicide ideation. In addition, drawing from multilevel developmental psychopathology theories, the interplay between parasympathetic regulation and friendship support, conceptualized as an external source of regulation, was examined. At baseline, 132 adolescent females (M age = 14.59, SD = 1.39) with a history of mental health concerns participated in an in vivo interpersonal stressor (a laboratory speech task) and completed self-report measures of depressive symptoms and perceived support within a close same-age female friendship. Respiratory sinus arrhythmia (RSA) was measured before and during the speech task. Suicide ideation was assessed at baseline and at 3, 6, and 9 months follow-up. The results revealed that females with greater relative RSA decreases to the laboratory stressor were at higher risk for reporting suicide ideation over the subsequent 9 months. Moreover, parasympathetic responses moderated the effect of friendship support on suicide ideation; among females with mild changes or higher relative increases in RSA, but not more pronounced RSA decreases, friendship support reduced risk for future suicide ideation. Findings highlight the crucial role of physiological and external regulation sources as protective factors for youth suicidality.

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Corresponding author
Address correspondence and reprint requests to: Matteo Giletta, Department of Developmental Psychology, Tilburg University, P.O. Box 90153, 5000 LE, Tilburg, The Netherlands; E-mail: m.giletta@uvt.nl; or Mitch Prinstein, Department of Psychology, University of North Carolina at Chapel Hill, Davie Hall, Campus Box 3270, Chapel Hill, NC 27599-3270; E-mail: mitch.prinstein@unc.edu.
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This work was supported in part by National Institute of Mental Health Grant R01-MH085505.

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References
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Banny, A. M., Heilbron, N., Ames, A., & Prinstein, M. J. (2011). Relational benefits of relational aggression: Adaptive and maladaptive associations with adolescent friendship quality. Developmental Psychology, 47, 11531156.
Baumeister, R. F. (1990). Suicide as escape from self. Psychological Review, 97, 90113.
Beauchaine, T. P. (2001). Vagal tone, development, and Gray's motivational theory: Toward an integrated model of autonomic nervous system functioning in psychopathology. Development and Psychopathology, 13, 183214.
Beauchaine, T. P. (2012). Physiological markers of emotion and behavior dysregulation in externalizing psychopathology. Monographs of the Society for Research in Child Development, 77, 7986.
Beauchaine, T. P. (2015). Future directions in emotion dysregulation and youth psychopathology. Journal of Clinical Child and Adolescent Psychology, 44, 875896.
Beauchaine, T. P., Gatzke-Kopp, L., & Mead, H. K. (2007). Polyvagal theory and developmental psychopathology: Emotion dysregulation and conduct problems from preschool to adolescence. Biological Psychology, 7, 174184.
Beauchaine, T. P., Klein, D. N., Crowell, S. E., Derbidge, C., & Gatzke-Kopp, L. (2009). Multifinality in the development of personality disorders: A Biology × Sex × Environment interaction model of antisocial and borderline traits. Development and Psychopathology, 21, 735770.
Belsky, J., & Pluess, M. (2009). Beyond diathesis-stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135, 885908.
Berntson, G. G., Bigger, J. T., Eckberg, D. L., Grossman, P., Kaufmann, P. G., Malik, M., … Van Der Molen, M. W. (1997). Heart rate variability: Origins, methods, and interpretive caveats. Psychophysiology, 34, 623648.
Berntson, G. G., Cacioppo, J. T., & Quigley, K. S. (1993). Respiratory sinus arrhythmia: Autonomic origins, physiological mechanisms, and psychophysiological implications. Psychophysiology, 30, 183196.
Berntson, G. G., Quigley, K. S., & Lozano, D. (2007). Cardiovascular psychophysiology. In Cacioppo, J. T., Tassinary, L. G., & Berntson, G. G. (Eds.), Handbook of psychophysiology (3rd ed., pp. 182210). Cambridge: Cambridge University Press.
Blakemore, S. J., Burnett, S., & Dahl, R. E. (2010). The role of puberty in the developing adolescent brain. Human Brain Mapping, 31, 926933.
Boergers, J., Spirito, A., & Donaldson, D. (1998). Reasons for adolescent suicide attempts: Associations with psychological functioning. Journal of the American Academy of Child & Adolescent Psychiatry, 37, 12871293.
Bowlby, J. (1969). Attachment and loss: Vol. 1. Attachment. New York: Basic Books.
Boyce, W. T., & Ellis, B. J. (2005). Biological sensitivity to context: I. An evolutionary–developmental theory of the origins and functions of stress reactivity. Development and Psychopathology, 17, 271301.
Bridge, J. A., Goldstein, T. R., & Brent, D. A. (2006). Adolescent suicide and suicidal behavior. Journal of Child Psychology and Psychiatry, 47, 372394.
Brindle, R. C., Ginty, A. T., & Conklin, S. M. (2013). Is the association between depression and blunted cardiovascular stress reactions mediated by perceptions of stress? International Journal of Psychophysiology, 90, 6672.
Burt, K. B., & Obradović, J. (2013). The construct of psychophysiological reactivity: Statistical and psychometric issues. Developmental Review, 33, 2957.
Cacioppo, J. T., Uchino, B. N., & Berntson, G. G. (1994). Individual differences in the autonomic origins of heart rate reactivity: The psychometrics of respiratory sinus arrhythmia and preejection period. Psychophysiology, 31, 412419.
Calhoun, C. D., Helms, S. W., Heilbron, N., Rudolph, K. D., Hastings, P. D., & Prinstein, M. J. (2014). Relational victimization, friendship, and adolescents’ hypothalamic–pituitary–adrenal axis responses to an in vivo social stressor. Development and Psychopathology, 26, 605618.
Calkins, S. D., & Fox, N. A. (2002). Self-regulaory processes in early personality development: A multilevel approach to the study of childhood social withdrawal and aggression. Development and Psychopathology, 14, 477498.
Casey, B. J., Jones, R. M., & Hare, T. A. (2008). The adolescent brain. Annals of the New York Academy of Sciences, 1124, 111126.
Centers for Disease Control and Prevention. (2014). Web-based Injury Statistics Query and Reporting System (WISQARS). Retrieved from https://cdc.gov/injury/wisqars
Cicchetti, D. (2008). A multiple-levels-of-analysis perspective on research in development and psychopathology. In Beauchaine, T. P. & Hinshaw, S. P. (Eds.), Child and adolescent psychopathology (pp. 2757). Hoboken, NJ: Wiley.
Coan, J. A., & Maresh, E. L. (2014). Social baseline theory and the social regulation of emotion. In Gross, J. (Ed.), Handbook of emotion regulation (pp. 221238). New York: Guilford Press.
Costello, E. J., & Angold, A. (1988). Scales to assess child and adolescent depression: Checklists, screens, and nets. Journal of the American Academy of Child & Adolescent Psychiatry, 27, 726737.
Crone, E. A., & Dahl, R. E. (2012). Understanding adolescence as a period of social–affective engagement and goal flexibility. Nature Reviews Neuroscience, 13, 636650.
Crowell, S. E., Beauchaine, T. P., McCauley, E., Smith, C. J., Stevens, A. L., & Sylvers, P. (2005). Psychological, autonomic, and serotonergic correlates of parasuicide among adolescent girls. Development and Psychopathology, 17, 11051127.
Crowell, S. E., Derbidge, C. M., & Beauchaine, P. (2014). Developmental approaches to understanding suicidal and self-injurious behaviors. In Nock, M. (Ed.), The Oxford handbook of suicide and self-Injury (pp. 183211). Oxford: Oxford University Press.
Daviss, W. B., Birmaher, B., Melhem, N. A., Axelson, D. A., Michaels, S. M., & Brent, D. A. (2006). Criterion validity of the Mood and Feelings Questionnaire for depressive episodes in clinic and non-clinic subjects. Journal of Child Psychology and Psychiatry, 47, 927934.
De Goede, I. H., Branje, S. J., & Meeus, W. H. (2009). Developmental changes in adolescents’ perceptions of relationships with their parents. Journal of Youth and Adolescence, 38, 7588.
Derbidge, C. M., & Beauchaine, T. P. (2014). A developmental model of self-inflicted injury, borderline personality, and suicide risk. In Lewis, M. & Rudolph, K. D. (Eds.), Handbook of developmental psychopathology (pp. 521542). New York: Springer.
Diamond, L. M., & Aspinwall, L. G. (2003). Emotion regulation across the life span: An integrative perspective emphasizing self-regulation, positive affect, and dyadic processes. Motivation and Emotion, 27, 125156.
Diamond, L. M., Fagundes, C. P., & Cribbet, M. R. (2012). Individual differences in adolescents’ sympathetic and parasympathetic functioning moderate associations between family environment and psychosocial adjustment. Developmental Psychology, 48, 918931.
Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2011). Differential susceptibility to the environment: An evolutionary–neurodevelopmental theory. Development and Psychopathology, 23, 728.
El-Sheikh, M., & Erath, S. A. (2011). Family conflict, autonomic nervous system functioning, and child adaptation: State of the science and future directions. Development and Psychopathology, 23, 703721.
El-Sheikh, M., Kouros, C. D., Erath, S., Cummings, E. M., Keller, P., & Staton, L. (2009). Marital conflict and children's externalizing behavior: Pathways involving interactions between parasympathetic and sympathetic nervous system activity. Monographs of the Society for Research in Child Development, 74, vii.
Forbes, E. E., & Dahl, R. E. (2010). Pubertal development and behavior: Hormonal activation of social and motivational tendencies. Brain and Cognition, 72, 6672.
Forbes, E. E., Phillips, M. L., Silk, J. S., Ryan, N. D., & Dahl, R. E. (2011). Neural systems of threat processing in adolescents: Role of pubertal maturation and relation to measures of negative affect. Developmental Neuropsychology, 36, 429452.
Fortunato, C. K., Gatzke-Kopp, L. M., & Ram, N. (2013). Associations between respiratory sinus arrhythmia reactivity and internalizing and externalizing symptoms are emotion specific. Cognitive, Affective, & Behavioral Neuroscience, 13, 238251.
Furman, W. (1996). The measurement of friendship perceptions: Conceptual and methodological issues. In Bukowski, W. M., Newcomb, A. F., & Hartup, W. W. (Eds.), The company they keep: Friendship in childhood and adolescence (pp. 4165). Cambridge: Cambridge University Press.
Furman, W., & Buhrmester, D. (1992). Age and sex differences in perceptions of networks of personal relationships. Child Development, 63, 103115.
Gentzler, A. L., Santucci, A. K., Kovacs, M., & Fox, N. A. (2009). Respiratory sinus arrhythmia reactivity predicts emotion regulation and depressive symptoms in at-risk and control children. Biological Psychology, 82, 156163.
Giletta, M., Prinstein, M. J., Abela, J. R., Gibb, B. E., Barrocas, A. L., & Hankin, B. L. (2015). Trajectories of suicide ideation and nonsuicidal self-injury among adolescents in mainland China: Peer predictors, joint development, and risk for suicide attempts. Journal of Consulting and Clinical Psychology, 83, 265279.
Graziano, P., & Derefinko, K. (2013). Cardiac vagal control and children's adaptive functioning: A meta-analysis. Biological Psychology, 94, 2237.
Gregson, K. D., Tu, K. M., & Erath, S. A. (2014). Sweating under pressure: Skin conductance level reactivity moderates the association between peer victimization and externalizing behavior. Journal of Child Psychology and Psychiatry, 55, 2230.
Gruenewald, T. L., Kemeny, M. E., Aziz, N., & Fahey, J. L. (2004). Acute threat to the social self: Shame, social self-esteem, and cortisol activity. Psychosomatic Medicine, 66, 915924.
Hammerfald, K., Eberle, C., Grau, M., Kinsperger, A., Zimmermann, A., Ehlert, U., & Gaab, J. (2006). Persistent effects of cognitive-behavioral stress management on cortisol responses to acute stress in healthy subjects—A randomized controlled trial. Psychoneuroendocrinology, 31, 333339.
Hastings, P. D., Kahle, S., & Han, H.-S. G. (2014). Developmental affective psychophysiology: Using physiology to inform our understanding of emotional development. In Lagatutta, K. (Ed.), Children and emotion: New insights into developmental affective science (Vol. 26, pp. 1328). Basel, Switzerland: Karger.
Hastings, P. D., Klimes-Dougan, B., Kendziora, K. T., Brand, A., & Zahn-Waxler, C. (2014). Regulating sadness and fear from outside and within: Mothers’ emotion socialization and adolescents’ parasympathetic regulation predict the development of internalizing difficulties. Development and Psychopathology, 26, 13691384.
Hastings, P. D., & Miller, J. G. (2014). Autonomic regulation, polyvagal theory, and children's prosocial development. In Padilla-Walker, L. & Carlo, G. (Eds.), The complexities of raising prosocial children (pp. 112127). Oxford: Oxford University Press.
Hastings, P. D., Sullivan, C., McShane, K. E., Coplan, R. J., Utendale, W. T., & Vyncke, J. D. (2008). Parental socialization, vagal regulation, and preschoolers’ anxious difficulties: Direct mothers and moderated fathers. Child Development, 79, 4564.
Hawton, K., Saunders, K. E., & O'Connor, R. C. (2012). Self-harm and suicide in adolescents. Lancet, 379, 23732382.
Houtveen, J. H., Groot, P. F., & Geus, E. J. (2005). Effects of variation in posture and respiration on RSA and pre-ejection period. Psychophysiology, 42, 713719.
Kaufman, J., Birmaher, B., Brent, D., Rao, U. M. A., Flynn, C., Moreci, P., … Ryan, N. (1997). Schedule for Affective Disorders and Schizophrenia for School-Age Children—Present and lifetime version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 980988.
King, C. A., & Merchant, C. R. (2008). Social and interpersonal factors relating to adolescent suicidality: A review of the literature. Archives of Suicide Research, 12, 181196.
Kirschbaum, C., Pirke, K. M., & Hellhammer, D. (1993). The “Trier Social Stress Test”—A tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology, 28, 7681.
Lakey, B., & Orehek, E. (2011). Relational regulation theory: A new approach to explain the link between perceived social support and mental health. Psychological Review, 118, 482495.
Laursen, B., DeLay, D., & Adams, R. E. (2010). Trajectories of perceived support in mother-adolescent relationships: The poor (quality) get poorer. Developmental Psychology, 46, 17921798.
Linehan, M. (1993). Cognitive-behavioral treatment of borderline personality disorder. New York: Guilford Press.
Luciana, M. (2013). Adolescent brain development in normality and psychopathology. Development and Psychopathology, 25, 13251345.
Mann, J. J. (2003). Neurobiology of suicidal behaviour. Nature Reviews Neuroscience, 4, 819828.
McLaughlin, K. A., Alves, S., & Sheridan, M. A. (2014). Vagal regulation and internalizing psychopathology among adolescents exposed to childhood adversity. Developmental Psychobiology, 56, 10361051.
McNelles, L. R., & Connolly, J. A. (1999). Intimacy between adolescent friends: Age and gender differences in intimate affect and intimate behaviors. Journal of Research on Adolescence, 9, 143159.
Monroe, S. M., & Simons, A. D. (1991). Diathesis-stress theories in the context of life stress research: Implications for the depressive disorders. Psychological Bulletin, 110, 406425.
Najmi, S., Wegner, D. M., & Nock, M. K. (2007). Thought suppression and self-injurious thoughts and behaviors. Behaviour Research and Therapy, 45, 19571965.
Nock, M. K., & Banaji, M. R. (2007). Prediction of suicide ideation and attempts among adolescents using a brief performance-based test. Journal of Consulting and Clinical Psychology, 75, 707715.
Nock, M. K., Green, J. G., Hwang, I., McLaughlin, K. A., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C. (2013). Prevalence, correlates, and treatment of lifetime suicidal behavior among adolescents: Results from the national comorbidity survey replication adolescent supplement. JAMA Psychiatry, 70, 300310.
Nock, M. K., Holmberg, E. B., Photos, V. I., & Michel, B. D. (2007). Self-Injurious Thoughts and Behaviors Interview: Development, reliability, and validity in an adolescent sample. Psychological Assessment, 19, 309317.
Obradović, J., Bush, N. R., & Boyce, W. T. (2011). The interactive effect of marital conflict and stress reactivity on externalizing and internalizing symptoms: The role of laboratory stressors. Development and Psychopathology, 23, 101114.
Obradović, J., Bush, N. R., Stamperdahl, J., Adler, N. E., & Boyce, W. T. (2010). Biological sensitivity to context: The interactive effects of stress reactivity and family adversity on socioemotional behavior and school readiness. Child Development, 81, 270289.
Pluess, M., & Belsky, J. (2013). Vantage sensitivity: Individual differences in response to positive experiences. Psychological Bulletin, 139, 901916.
Porges, S. W. (1995). Orienting in a defensive world: Mammalian modifications of our evolutionary heritage. A polyvagal theory. Psychophysiology, 32, 301318.
Porges, S. W. (2003). Social engagement and attachment: A phylogenetic perspective. Annals of the New York Academy of Sciences, 1008, 3147.
Porges, S. W. (2007). The polyvagal perspective. Biological Psychology, 74, 116143.
Porges, S. W., & Byrne, E. A. (1992). Research methods for measurement of heart rate and respiration. Biological Psychology, 34, 93130.
Preacher, K. J., Curran, P. J., & Bauer, D. J. (2006). Computational tools for probing interactions in multiple linear regression, multilevel modeling, and latent curve analysis. Journal of Educational and Behavioral Statistics, 31, 437448.
Prinstein, M. J., Boergers, J., Spirito, A., Little, T. D., & Grapentine, W. L. (2000). Peer functioning, family dysfunction, and psychological symptoms in a risk factor model for adolescent inpatients’ suicide ideation severity. Journal of Clinical Child Psychology, 29, 392405.
Prinstein, M. J., & Giletta, M. (2016). Peer relations and developmental psychopathology. In Cicchetti, D. (Ed.), Developmental psychopathology (3rd ed., Vol. 1, pp. 527579). Hoboken, NJ: Wiley.
Prinstein, M. J., Nock, M. K., Simon, V., Aikins, J. W., Cheah, C. S. L., & Spirito, A. (2008). Longitudinal trajectories and predictors of adolescent suicidal ideation and attempts following inpatient hospitalization. Journal of Consulting and Clinical Psychology, 76, 92103.
Reynolds, C. R., & Kamphaus, R. W. (1992). BASC: Behavior Assessment System for Children: Manual. Circle Pines, MN: American Guidance Service.
Robinson, J., Hetrick, S. E., & Martin, C. (2011). Preventing suicide in young people: Systematic review. Australian and New Zealand Journal of Psychiatry, 45, 326.
Roisman, G. I., Newman, D. A., Fraley, R. C., Haltigan, J. D., Groh, A. M., & Haydon, K. C. (2012). Distinguishing differential susceptibility from diathesis–stress: Recommendations for evaluating interaction effects. Development and Psychopathology, 24, 389409.
Rose, A. J. (2002). Co-rumination in the friendships of girls and boys. Child Development, 73, 18301843.
Rose, A. J., & Rudolph, K. D. (2006). A review of sex differences in peer relationship processes: Potential trade-offs for the emotional and behavioral development of girls and boys. Psychological Bulletin, 132, 98131.
Rudolph, K. D., Troop-Gordon, W., & Granger, D. A. (2011). Individual differences in biological stress responses moderate the contribution of early peer victimization to subsequent depressive symptoms. Psychopharmacology, 214, 209219.
Shanahan, L., Calkins, S. D., Keane, S. P., Kelleher, R., & Suffness, R. (2014). Trajectories of internalizing symptoms across childhood: The roles of biological self-regulation and maternal psychopathology. Development and Psychopathology, 26, 13531368.
Sijtsema, J. J., Nederhof, E., Veenstra, R., Ormel, J., Oldehinkel, A. J., & Ellis, B. J. (2013). Effects of family cohesion and heart rate reactivity on aggressive/rule-breaking behavior and prosocial behavior in adolescence: The Tracking Adolescents’ Individual Lives Survey study. Development and Psychopathology, 25, 699712.
Somerville, L. H., Jones, R. M., & Casey, B. J. (2010). A time of change: Behavioral and neural correlates of adolescent sensitivity to appetitive and aversive environmental cues. Brain and Cognition, 72, 124133.
Suveg, C., Kendall, P. C., Comer, J. S., & Robin, J. (2006). Emotion-focused cognitive–behavioral therapy for anxious youth: A multiple-baseline evaluation. Journal of Contemporary Psychotherapy, 36, 7785.
Sun, R. C. F., & Hui, E. K. P. (2007). Psychosocial factors contributing to adolescent suicide ideation. Journal of Youth and Adolescence, 36, 775786.
Tamás, Z., Kovacs, M., Gentzler, A. L., Tepper, P., Gádoros, J., Kiss, E., … Vetró, Á. (2007). The relations of temperament and emotion self-regulation with suicidal behaviors in a clinical sample of depressed children in Hungary. Journal of Abnormal Child Psychology, 35, 640652.
Task Force of the European Society of Cardiology. (1996). The North American Society of Pacing and Electrophysiology. Heart rate variability: Standards of measurement, physiological interpretation and clinical use. Circulation, 93, 10431065.
Taylor, S. E., Klein, L. C., Lewis, B. P., Gruenewald, T. L., Gurung, R. A., & Updegraff, J. A. (2000). Biobehavioral responses to stress in females: Tend-and-befriend, not fight-or-flight. Psychological Review, 107, 411429.
Van Orden, K. A., Witte, T. K., Cukrowicz, K. C., Braithwaite, S. R., Selby, E. A., & Joiner, T. E. Jr. (2010). The interpersonal theory of suicide. Psychological Review, 117, 575600.
Wang, Y. G., & Carey, V. (2003). Working correlation structure misspecification, estimation and covariate design: Implications for generalised estimating equations performance. Biometrika, 90, 2941.
Zaki, J., & Williams, W. C. (2013). Interpersonal emotion regulation. Emotion, 13, 803810.
Zeger, S. L., Liang, K. Y., & Albert, P. S. (1988). Models for longitudinal data: A generalized estimating equation approach. Biometrics, 44, 10491060.
Zeman, J., Cassano, M., & Adrian, M. C. (2013). Socialization influences on children's and adolescents’ emotional self-regulation processes. In Barrett, K. C., Fox, N. A., Morgan, G. A., Fidler, D. J., & Daunhauer, L. A. (Eds.), Handbook of self-regulatory processes in development: New directions and international perspectives (pp. 79106). New York: Psychology Press.
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