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Estimation of LD50 by moving averages

Published online by Cambridge University Press:  15 May 2009

B. M. Bennett
B. M. Bennett
Affiliation:
School of Medicine, University of Washington.
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Methods of graduation of a series of observations by means of moving averages were discussed by Sheppard (1914), and subsequently by Sherriff (1920) and a number of other writers. These methods based on least squares or weighted least squares solutions differ from actuarial or summation methods. Thompson (1947) has proposed that the method of moving averages be considered a ‘basic’ one in the estimation of the median effective dose (LD50) of bioassay data. On the basis of an empirical study of the data of Topley and Wilson he recommended in particular the use of a three-term moving average. In a recent paper, Finney (1950) has discussed the efficiency of Thompson's moving average method generally.

Type
Research Article
Information
Journal of Hygiene , Volume 50 , Issue 2 , June 1952 , pp. 157 - 164
Copyright
Copyright © Cambridge University Press 1952

References

REFERENCES

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