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Lessons from Nigeria: the role of roads in the geo-temporal progression of avian influenza (H5N1) virus

  • A. L. RIVAS (a1) (a2), G. CHOWELL (a3) (a4), S. J. SCHWAGER (a2), F. O. FASINA (a5) (a6), A. L. HOOGESTEIJN (a7), S. D. SMITH (a2), S. P. R. BISSCHOP (a6), K. L. ANDERSON (a1) and J. M. HYMAN (a8)...
Summary
SUMMARY

The daily progression of the 2006 (January–June) Nigerian avian influenza (AI H5N1) epidemic was assessed in relation to both spatial variables and the generation interval of the invading virus. Proximity to the highway network appeared to promote epidemic dispersal: from the first AI generation interval onwards >20% of all cases were located at <5 km from the nearest major road. Fifty-seven per cent of all cases were located ⩽31 km from three highway intersections. Findings suggest that the spatial features of emerging infections could be key in their control. When the spatial location of a transmission factor is well known, such as that of the highway network, and a substantial percentage of cases (e.g. >20%) are near that factor, early interventions focusing on transmission factors, such as road blocks that prevent poultry trade, may be more efficacious than interventions applied only to the susceptible population.

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Corresponding author
*Author for correspondence: Dr A. L. Rivas, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St, Raleigh, NC, USA. (Email: alrivas@ncsu.edu or alr4@cornell.edu)
References
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1. Cook RL, et al. What's driving an epidemic? The spread of syphilis along an interstate highway in rural North Carolina. American Journal of Public Health 1999; 89: 369373.
2. Rivas AL, et al. Identification of geographical factors associated with early epidemic spread of foot-and-mouth disease. American Journal of Veterinary Research 2003; 64: 15191527.
3. Grassly NC, Fraser C. Mathematical models of infectious disease transmission. Nature Reviews Microbiology 2008; 6: 477487.
4. Das A, et al. Detection of H5N1 high-pathogenicity avian influenza virus in meat and tracheal samples from experimentally infected chickens. Avian Diseases 2008; 52: 4048.
5. Stegeman A, et al. Avian influenza A virus (H7N7) epidemic in The Netherlands in 2003: course of the epidemic and effectiveness of control measures. Journal of Infectious Diseases 2004; 190: 20882095.
6. LeMenach , et al. Key strategies for reducing spread of avian influenza among commercial poultry holdings: lessons for transmission to humans. Proceedings of the Royal Society of London Series B: Biological Sciences 2006; 273: 24672475.
7. Brown JD, et al. Persistence of H5 and H7 avian influenza viruses in water. Avian Diseases 2007; 51: 285289.
8. Fasina FO, et al. Molecular characterization and epidemiology of the highly pathogenic avian influenza H5N1 in Nigeria. Epidemiology and Infection 2009: 137: 456463.
9. Adene DF, Oguntade AE.The structure and importance of the commercial and village based poultry industry in Nigeria (http://www.fao.org/docs/eims/upload//214281/poultrysector_nga_en.pdf). Accessed 1 May 2007.
11. Woolhouse MEJ, et al. Heterogeneities in the transmission of infectious agents: implications for the design of control programs. Proceedings of the National Academy of Sciences USA 1997; 94: 338342.
12. Lau EHY, et al. Effect of interventions on Influenza A (H9N2) isolation in Hong Kong's live poultry markets, 1999–2005. Emerging Infectious Diseases 2007; 13: 13401347.
13. Phillips CV, Goodman KJ. The missed lessons of Sir Austin Bradford Hill. Epidemiological Perspectives and Innovations 2004; 1: 3.
14. Koopman J. Modeling infection transmission. Annual Review of Public Health 2004; 25: 303326.
15. Snow SJ. Commentary: Sutherland, Snow and water: the transmission of cholera in the nineteenth century. International Journal of Epidemiology 2002; 31: 908911.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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