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Gene expression profiling of suicide completers

Published online by Cambridge University Press:  16 April 2020

L.M. Fiori  and
G. Turecki
L.M. Fiori
Affiliation:
McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
G. Turecki*
Affiliation:
McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
*
*Corresponding author. Douglas Mental Health University Institute, 6875 LaSalle Boulevard, Verdun, Quebec, Canada, H4H 1R3. Tel.: +1 514 761 6131x2369; fax: +1 514 762 3023. E-mail address: gustavo.turecki@mcgill.ca (G. Turecki).
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Abstract

Despite strong evidence for a role of biological factors in the etiology and pathology of suicide, the study of traditional neurotransmitter systems has been able to explain only a small proportion of the neurobiology of what is now recognized as a complex genetic trait. The use of microarrays to simultaneously examine the expression levels of thousands of gene transcripts has vastly expanded our capacity to detect the involvement of additional genes and pathways in suicidality, and has opened many new avenues for the discovery of the biological underpinnings of suicide completion. This review examines microarray studies which have been used to identify genes displaying altered expression in suicide completers, and highlights some of the important methodological considerations and metabolic pathways which have emerged from these analyses.

Keywords

SuicideGene expressionMicroarrayGlutamateGABAPolyamines

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References

Altar, CA, Vawter, MP, Ginsberg, SDTarget identification for CNS diseases by transcriptional profiling. Neuropsychopharmacology 2009;34:18–54.CrossRefGoogle ScholarPubMed
Brent, DA, Mann, JJFamily genetic studies, suicide, and suicidal behavior. Am J Med Genet C Semin Med Genet 2005;133:13–24.10.1002/ajmg.c.30042CrossRefGoogle Scholar
Choudary, PV, Molnar, M, Evans, SJ, Tomita, H, Li, JZ, Vawter, MPet al.Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Natl Acad Sci U S A 2005;102:15653–15658.CrossRefGoogle ScholarPubMed
Ernst, C, Deleva, V, Deng, X, Sequeira, A, Pomarenski, A, Klempan, Tet al.Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers. Arch Gen Psychiatry 2009;66:22–32.10.1001/archpsyc.66.1.22CrossRefGoogle ScholarPubMed
Ernst, C, Bureau, A, Turecki, GApplication of microarray outlier detection methodology to psychiatric research. BMC Psychiatry 2008;8:29.10.1186/1471-244X-8-29CrossRefGoogle ScholarPubMed
Fiori, LM, Turecki, GImplication of the polyamine system in mental disorders. J Psychiatry Neurosci 2008;33:102–110.Google ScholarPubMed
Guipponi, M, Deutsch, S, Kohler, K, Perroud, N, Le Gal, F, Vessaz, Met al.Genetic and epigenetic analysis of SSAT gene dysregulation in suicidal behavior. Am J Med Genet B Neuropsychiatr Genet 150B 2008 799–807.10.1002/ajmg.b.30901CrossRefGoogle Scholar
Gwadry, FG, Sequeira, A, Hoke, G, Ffrench-Mullen, JM, Turecki, GMolecular characterization of suicide by microarray analysis. Am J Med Genet C Semin Med Genet 133C 2005 48–56.CrossRefGoogle ScholarPubMed
Iwamoto, K, Kato, TGene expression profiling in schizophrenia and related mental disorders. Neuroscientist 2006;12:349–361.10.1177/1073858406287536CrossRefGoogle ScholarPubMed
Kim, S, Choi, KH, Baykiz, AF, Gershenfeld, HKSuicide candidate genes associated with bipolar disorder and schizophrenia: an exploratory gene expression profiling analysis of postmortem prefrontal cortex. BMC Genomics 2007;8:413.CrossRefGoogle Scholar
Klempan, TA, Sequeira, A, Canetti, L, Lalovic, A, Ernst, C, Ffrench-Mullen, Jet al.Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression. Mol Psychiatry 2009;14:175–189.CrossRefGoogle ScholarPubMed
Klempan, TA, Rujescu, D, Mérette, C, Himmelman, C, Sequeira, A, Canetti, Let al.Profiling brain expression of the spermidine/spermine N(1)-acetyltransferase 1 (SAT1) gene in suicide. Am J Med Genet B Neuropsychiatr Genet 150B 2009 934–943.CrossRefGoogle ScholarPubMed
Sequeira, A, Turecki, GGenome wide gene expression studies in mood disorders. OMICS 2006;10:444–454.10.1089/omi.2006.10.444CrossRefGoogle ScholarPubMed
Sequeira, A, Mamdani, F, Ernst, C, Vawter, MP, Bunney, WE, Lebel, Vet al.Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression. PLoS ONE 2009;4:e6585.10.1371/journal.pone.0006585CrossRefGoogle ScholarPubMed
Sequeira, A, Gwadry, FG, Ffrench-Mullen, JM, Canetti, L, Gingras, Y, Casero, RA Jr.et al.Implication of SSAT by gene expression and genetic variation in suicide and major depression. Arch Gen Psychiatry 2006;63:35–48.10.1001/archpsyc.63.1.35CrossRefGoogle ScholarPubMed
Sequeira, A, Klempan, T, Canetti, L, ffrench-Mullen, J, Benkelfat, C, Rouleau, GAet al.Patterns of gene expression in the limbic system of suicides with and without major depression. Mol Psychiatry 2007;12:640–655.10.1038/sj.mp.4001969CrossRefGoogle ScholarPubMed
Sibille, E, Arango, V, Galfalvy, HC, Pavlidis, P, Erraji-Benchekroun, L, Ellis, SPet al.Gene expression profiling of depression and suicide in human prefrontal cortex. Neuropsychopharmacology 2004;29:351–361.10.1038/sj.npp.1300335CrossRefGoogle ScholarPubMed
Thalmeier, A, Dickmann, M, Giegling, I, Schneider, B, Hartmann, MA, Maurer, Ket al.Gene expression profiling of postmortem orbitofrontal cortex in violent suicide victims. Int J Neuropsychopharmacol 2008;11:217–228.10.1017/S1461145707007894CrossRefGoogle ScholarPubMed
Tochigi, M, Iwamoto, K, Bundo, M, Sasaki, T, Kato, N, Kato, TGene expression profiling of major depression and suicide in the prefrontal cortex of postmortem brains. Neurosci Res 2008;60:184–191.CrossRefGoogle ScholarPubMed
Yanagi, M, Shirakawa, O, Kitamura, N, Okamura, K, Sakurai, K, Nishiguchi, Net al.Association of 14-3-3 epsilon gene haplotype with completed suicide in Japanese. J Hum Genet 2005;50:210–216.10.1007/s10038-005-0241-0CrossRefGoogle ScholarPubMed
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