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Increased allergic reactivity of atopic type in mood disorders and schizophrenia

Published online by Cambridge University Press:  16 April 2020

M Dabkowska  and
JK Rybakowski
M Dabkowska
Affiliation:
Department of Psychiatry, Medical Academy, ul. Kurpińskiego 19, 85-096Bydgoszcz
JK Rybakowski
Affiliation:
Department of Adult Psychiatry, University of Medical Sciences. ul. Szpitalna 27/33. 60-572Poznań, Poland
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Summary

The allergic reactivity of atopic type was investigated in 54 patients with mood disorders in the course of depressive episode and in 39 patients with schizophrenia. The assessment was done by three methods: intradermal tests, determination of IgE concentration and determination of specific immunoglobulin E (IgE) antibodies. The hypersensitivity to three or more allergens on intradermal tests was found in 40% of depressive and in 27% of schizophrenic patients. The concentration of IgE > 100 IU/mL was found in 45% of patients with depression and in 46% of patients with schizophrenia, more frequently in subjects with hyperactivity of hypothalamic-pituitary-adrenal axis, and in depression, in patients with higher intensity of symptoms. The positive results of the Phadiatop test which detects specific antibodies for inhalatory antigens, were found in 46% of depressive and in 40% of schizophrenic patients The indices of atopy for all three tests were higher in males than in females in both mood disorders and in schizophrenia. However, these indices were similar for unipolar and bipolar depressed patients as well as for patients with paranoid or residual schizophrenia.

Keywords

allergydepressionschizophrenia
Type
Original articles
Information
European Psychiatry , Volume 12 , Issue 5 , 1997 , pp. 249 - 254
Copyright
Copyright © European Psychiatric Association 1997

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