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Symptomatic remission and social/vocational functioning in outpatients with schizophrenia: Prevalence and associations in a cross-sectional study

Published online by Cambridge University Press:  16 April 2020

Luis San
Affiliation:
Hospital San Rafael, Barcelona, Spain
Antonio Ciudad*
Affiliation:
Lilly Research Laboratories S.A., Avda. de la Industria 30, 28108 Alcobendas, Madrid, Spain
Enrique Álvarez
Affiliation:
Department of Psychiatry, Hospital de Sant Pau, UAB, REM-TAP, Barcelona, Spain
Julio Bobes
Affiliation:
Área de Psiquiatría, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain
Inmaculada Gilaberte
Affiliation:
Lilly Research Laboratories S.A., Avda. de la Industria 30, 28108 Alcobendas, Madrid, Spain
*
*Corresponding author. Tel.: +34 91 623 35 70; fax: +34 91 663 34 71. E-mail addresses:12636lsm@comb.es (L. San), ciudad_antonio@lilly.com (A. Ciudad), ealvarezm@hsp.santpau.es (E. Álvarez), bobes@correo.uniovi.es (J. Bobes), gilaberte_inmaculada@lilly.com (I. Gilaberte).
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Abstract

Purpose

Progress in therapeutic options for schizophrenia has revived long-term expectations of researchers, practitioners and patients. At present, definitions of therapeutic outcome include both maintained symptomatic remission and appropriate functioning in a conceptual framework that targets patient's recovery as the ultimate goal. We aimed to know the prevalence and clinical features of patients with schizophrenia achieving these outcomes.

Methods

A multi-centre, cross-sectional study was performed in more than 100 mental health facilities within Spain. Recently published consensus-based operational criteria for symptomatic remission and the Global Assessment of Functioning scale were used to evaluate outcomes. Other clinical aspects like depressive symptoms, social cognition, premorbid adjustment and patients' attitudes to medication were also evaluated.

Results

Data from 1010 patients were analysed. Of these, 452 (44.8%) were at clinical remission, but only 103 (10.2%) showed an adequate social and/or vocational functioning. Factors predicting both outcomes were better pre-morbid adjustment (odds ratio, OR = 1.56) and better social cognitive function (OR = 1.14). Other factors, like treatment adherence, current or past psychotherapy and patient's age were not associated to functionality but only to clinical remission. Current substance use and previous rehabilitation were associated to a lower likelihood of symptomatic remission.

Conclusion

Although symptomatic remission in patients with schizophrenia is a realistic and reachable goal, future efforts should be directed to a sustained appropriate functioning in these patients.

Type
Original article
Copyright
Copyright © Elsevier Masson SAS 2007

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