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Behavior problems associated with brain heterotopia

Published online by Cambridge University Press:  13 August 2021

M. Budisteanu ,
S. Papuc ,
A. Erbescu ,
C. Iliescu ,
M. Dobre ,
D. Barca ,
O. Tarta-Arsene ,
C. Motoescu ,
A. Dica  and
C. Sandu
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M. Budisteanu*
Affiliation:
Psychaitry Research Laboratory, Obregia Clinical Hospital of Psychiatry, Bucharest, Romania
S. Papuc
Affiliation:
Genetics Laboratory, ‘Victor Babes’ National Institute of Pathology, Bucharest, Romania
A. Erbescu
Affiliation:
Genetics Laboratory, ‘Victor Babes’ National Institute of Pathology, Bucharest, Romania
C. Iliescu
Affiliation:
Psychaitry Research Laboratory, Obregia Clinical Hospital of Psychiatry, Bucharest, Romania
M. Dobre
Affiliation:
Genetics Laboratory, ‘Victor Babes’ National Institute of Pathology, Bucharest, Romania
D. Barca
Affiliation:
Psychaitry Research Laboratory, Obregia Clinical Hospital of Psychiatry, Bucharest, Romania
O. Tarta-Arsene
Affiliation:
Psychaitry Research Laboratory, Obregia Clinical Hospital of Psychiatry, Bucharest, Romania
C. Motoescu
Affiliation:
Psychaitry Research Laboratory, Obregia Clinical Hospital of Psychiatry, Bucharest, Romania
A. Dica
Affiliation:
Psychaitry Research Laboratory, Obregia Clinical Hospital of Psychiatry, Bucharest, Romania
C. Sandu
Affiliation:
Psychaitry Research Laboratory, Obregia Clinical Hospital of Psychiatry, Bucharest, Romania
C. Anghelescu
Affiliation:
Psychaitry Research Laboratory, Obregia Clinical Hospital of Psychiatry, Bucharest, Romania
D. Craiu
Affiliation:
Psychaitry Research Laboratory, Obregia Clinical Hospital of Psychiatry, Bucharest, Romania
A. Arghir
Affiliation:
Genetics Laboratory, ‘Victor Babes’ National Institute of Pathology, Bucharest, Romania
*
*Corresponding author.

Abstract

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Introduction

Brain heterotopia represent a group of rare malformations with a heterogeneous phenotype, ranging from asymptomatic to severe clinical picture (resistant epilepsy, severe developmental delay). The etiology is multifactorial, including both genetic and environmental factors.

Objectives

In this paper we present our experience regarding behavior problems in patients with heterotopia.

Methods

A cohort of 16 pediatric patients with brain heterotopia, six females and ten males, with age at last follow-up ranging from 2 months to 24 years were investigated by clinical examination, electroencephalographic studies, brain imaging, and genomic tests. Specific psychological tests and psychiatric evaluation were performed in all children for behavior problems assessment.

Results

Six individuals presented behavioral problems: autism (three patients) and hyperkinesia with attention deficit (three patients). All of them had intellectual disability or learning problems; five patients had epilepsy, with drug-resistant seizures in four cases. In two cases the behavioral problems occurred before the onset of epileptic seizures.

Conclusions

Behavior problems are important features in patients with brain heterotopia, making the management of these patients more difficult, especially when they occur in association with drug-resistant epilepsy. Acknowledgements: This work was supported partially by grants of the Romanian National Authority for Scientific Research and Innovation CCCDI – UEFISCDI, Projects COFUND-ERANET E-RARE 3-HETER-OMICS-2 Number 87/2019 and 88/2019 within PNCDI III.

Disclosure

No significant relationships.

Keywords

hyperkinesia with attention deficitautismEpilepsybrain heterotopia
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S638 - S639
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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