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Increased risk of psychosis to ivermectin treatment

Published online by Cambridge University Press:  01 September 2022

A. Romero Calderon ,
M. Marín Valdovino ,
A.M. González Meléndez ,
J. Leiva Soto  and
A. Garcia Baltazar
A. Romero Calderon*
Affiliation:
HOSPITAL SAN JUAN DE DIOS, EnseÑanza, ZAPOPAN, Mexico
M. Marín Valdovino
Affiliation:
HOSPITAL SAN JUAN DE DIOS, EnseÑanza, ZAPOPAN, Mexico
A.M. González Meléndez
Affiliation:
Hospital San Juan De Dios, Psiquiatria, Zapopan, Mexico
J. Leiva Soto
Affiliation:
HOSPITAL SAN JUAN DE DIOS, EnseÑanza, ZAPOPAN, Mexico
A. Garcia Baltazar
Affiliation:
HOSPITAL SAN JUAN DE DIOS, EnseÑanza, ZAPOPAN, Mexico
*
*Corresponding author.

Abstract

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Introduction

Adolescence: a state of mental fragility, where psychiatric disorders may debut, where have been reported several cases of toxidermy, encephalopathy and neuropsychiatric disorder related to ivermectin treatment (excluding organicity, substance abuse or medication) (1). It has effect on the dopaminergic system with an alteration on glycoprotein P leading to high levels of ivermectin causing neurotoxicity (2). In this poster, we discuss the case of a 14 y/o´s psychosis to ivermectin

Objectives

Presentation of a clinical report

Methods

14 years old woman. Background: father with schizophrenia. Comorbility: None. Initially, presented to ER with 2 week of treatment to ivermectin 6mg for pediculosis; presenting first psychotic episode. She presented first clinical outbreak of psychosis characterized by mystical-religious, erotomaniac, harm and reference delusions, auditory and visual hallucinations adding isolation, abulia, apathy, dialogued soliloquies, and spontaneous crying. No prior psychiatric treatment.

Results

In hospitalization: elevated indirect and direct bilirubins and hiponatremia; neuroimaging studies are reported normal. Haloperidol 7.5 mg/day is indicated and parkinsonism is presented. Treatment is changed to olanzapine 15mg/day with notorious improvement. Diagnostic impression: Acute polymorphic psychotic disorder with symptoms of schizophrenia

Conclusions

Possible causes were analyzed, finding a relationship with ivermectin treatment. This case makes evident the importance of conducting in-depht evaluations and finding risks factors for psychosis.

Disclosure

No significant relationships.

Keywords

IvermectinPsychosis
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S800
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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