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A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps

  • J. Radua (a1) (a2), D. Mataix-Cols (a1), M.L. Phillips (a3) (a4), W. El-Hage (a5), D.M. Kronhaus (a6), N. Cardoner (a7) and S. Surguladze (a1) (a6)...


Meta-analyses are essential to summarize the results of the growing number of neuroimaging studies in psychiatry, neurology and allied disciplines. Image-based meta-analyses use full image information (i.e. the statistical parametric maps) and well-established statistics, but images are rarely available making them highly unfeasible. Peak-probability meta-analyses such as activation likelihood estimation (ALE) or multilevel kernel density analysis (MKDA) are more feasible as they only need reported peak coordinates. Signed-differences methods, such as signed differential mapping (SDM) build upon the positive features of existing peak-probability methods and enable meta-analyses of studies comparing patients with controls. In this paper we present a new version of SDM, named Effect Size SDM (ES-SDM), which enables the combination of statistical parametric maps and peak coordinates and uses well-established statistics. We validated the new method by comparing the results of an ES-SDM meta-analysis of studies on the brain response to fearful faces with the results of a pooled analysis of the original individual data. The results showed that ES-SDM is a valid and reliable coordinate-based method, whose performance might be additionally increased by including statistical parametric maps. We anticipate that ES-SDM will be a helpful tool for researchers in the fields of psychiatry, neurology and allied disciplines.


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*Corresponding author. Tel.: +44 20 78 48 03 63; fax: +44 78 48 03 79. E-mail (J. Radua).


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A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps

  • J. Radua (a1) (a2), D. Mataix-Cols (a1), M.L. Phillips (a3) (a4), W. El-Hage (a5), D.M. Kronhaus (a6), N. Cardoner (a7) and S. Surguladze (a1) (a6)...


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A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps

  • J. Radua (a1) (a2), D. Mataix-Cols (a1), M.L. Phillips (a3) (a4), W. El-Hage (a5), D.M. Kronhaus (a6), N. Cardoner (a7) and S. Surguladze (a1) (a6)...
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