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Nicotinic Acetylcholine Receptor α4 Subunit Gene Variation Associated with Chinese Han Patients with Attention Deficit Hyperactivity Disorder

Published online by Cambridge University Press:  16 April 2020

J. Weidong ,
H. Xuezhu ,
G. Tianyou ,
Y. Chuang ,
L. Qianqian ,
X. Yong  and
G. Lanting
J. Weidong
Affiliation:
Shanghai Changning Mental Health Center/Bio-X Center Hospital of Shanghai Jiaotong University, Shanghai, China
H. Xuezhu
Affiliation:
Psychiatry, School of Medicine, Tsinghua University, Beijing, China
G. Tianyou
Affiliation:
Department of Psychology, Normal College, Shenzhen University, Shenzhen, China
Y. Chuang
Affiliation:
Psychiatry, Medical College of Wenzhou, Wenzhou, China
L. Qianqian
Affiliation:
Psychiatry, West China Hospital of Sichuan University, Chengdu, China
X. Yong
Affiliation:
School of Medicine of Tsinghua University, Beijing, China
G. Lanting
Affiliation:
West China Hospital of Sichuan University, Chengdu, China

Abstract

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Previous pharmacological, human genetical, and animal models have implicated the nicotinic acetylcholine receptor α4 subunit (CHRNA4) gene in the pathogenesis of ADHD. The objective of this study is to examine genetic association between single nucleotide polymorphisms (SNPs) in the CHRNA4 gene (rs2273502, rs1044396, rs1044397 and rs3827020 loci) and ADHD. Both case-control and family-based design were used in this study. Children aged 6 to 16 years were interviewed and assessed with the CBCL and CPRS-R to identify probands. No significant differences in frequency distribution of genotypes or alleles between the case and control groups were found. However, further haplotype analyses showed CCGG haplotype on risk for ADHD in 164 case-control sample and TDT analysis suggested that the allele C of rs2273502 over-transferred in 98 ADHD parent-offspring trios. Our findings suggest that CHRNA4 gene may play a role in the pathogenesis of ADHD, and further work is necessary to replicate and confirm what role the CHRNA4 gene may play in the etiology and pathogenesis of ADHD in large independent samples.

Type
P01-14
Information
European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E402
Copyright
Copyright © European Psychiatric Association 2009
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