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No evidence for deficient set-shifting in obsessive-compulsive disorder

Published online by Cambridge University Press:  16 April 2020

E. Fadda ,
S. Sottocorno ,
R. Martoni ,
E. Galimberti  and
L. Bellodi
E. Fadda
Affiliation:
Faculty of Psychology, Milan, Italy
S. Sottocorno
Affiliation:
Faculty of Psychology, Milan, Italy
R. Martoni
Affiliation:
Faculty of Psychology, Milan, Italy
E. Galimberti
Affiliation:
Faculty of Psychology, Milan, Italy European Institute of Experimental Neurology, Milan, Italy
L. Bellodi
Affiliation:
Faculty of Psychology, Milan, Italy Department of Clinical Neuroscience, Vita-Salute San Raffaele University, Milan, Italy

Abstract

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Introduction

Various neurocognitive deficits have been identified across several domains in Obsessive-Compulsive Disorder (OCD), including memory, response inhibition attentional processing and cognitive flexibility.

Objective

The aim of this study was to evaluate Set Shifting in patients with Obsessive-Compulsive Disorder compared with Healthy Controls (HC).

Methods

44 OCD patients, according to DSM-IV criteria (APA, 1994) and 32 healthy controls (HC) were recruited. Information Sampling Task (IST) selected from Cambridge Neuropsychological Test Automated Battery (CANTAB) was administered to all participants to assess cognitive flexibility. The two IST versions were counterbalanced in the samples. Delta index has been calculated as the difference between the number of the boxes opened in the fixed condition and the number of boxes opened in the decrease condition.

Results

Group differences in Delta IST were assessed within an analysis of covariance (ANCOVA) model including Groups (control vs. OCD) as between-subject factor and age as a covariate. Results show a no significant main effect for group on IST Delta index (p = 0.26). A significant effect of the covariates (age) on Delta IST(p = 0.027) was found.

Conclusion

Results suggests that cognitive flexibility, assessed by Information Sampling Task, was not impaired in OCD patients. Future research should evaluate this evidence, taking in account for OCD clinical subtypes.

Type
P01-153
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 153
Copyright
Copyright © European Psychiatric Association 2011
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