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Platelet serotonin decrease in panic disorder with obsessive compulsive symptoms

Published online by Cambridge University Press:  16 April 2020

D Servant ,
D Bailly ,
C Perret ,
J Vignau  and
PJ Parquet
D Servant
Affiliation:
Consultation Spécialisée sur l’Anxiété, Unité de Psychopathologie et Alcoologie, CHU de Lille, Hôpital de la Charité, 196 boulevard Montebello, 59037 Lille Cedex, France
D Bailly
Affiliation:
Consultation Spécialisée sur l’Anxiété, Unité de Psychopathologie et Alcoologie, CHU de Lille, Hôpital de la Charité, 196 boulevard Montebello, 59037 Lille Cedex, France
C Perret
Affiliation:
Consultation Spécialisée sur l’Anxiété, Unité de Psychopathologie et Alcoologie, CHU de Lille, Hôpital de la Charité, 196 boulevard Montebello, 59037 Lille Cedex, France
J Vignau
Affiliation:
Consultation Spécialisée sur l’Anxiété, Unité de Psychopathologie et Alcoologie, CHU de Lille, Hôpital de la Charité, 196 boulevard Montebello, 59037 Lille Cedex, France
PJ Parquet
Affiliation:
Consultation Spécialisée sur l’Anxiété, Unité de Psychopathologie et Alcoologie, CHU de Lille, Hôpital de la Charité, 196 boulevard Montebello, 59037 Lille Cedex, France
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Summary

Platelet 5-HT levels were determined by fluorescent orthophthaldehyde assay in 33 panic disorder patients with and without obsessive compulsive symptoms (PD + OCS: n = 16; PD-OCS: n = 17) according to DSM III-R criteria, and compared With those of 38 healthy controls. Mean platelet levels were significantly lower in PD + OCS than in PD-OCS patients. The results are discussed in relation to serotonergic dysfunction linked to PD and OCS comorbidity.

Keywords

serotoninpanic disorderobsessive-compulsive disorderplatelet

Information

Type
Original article
Information
European Psychiatry , Volume 7 , Issue 1 , 1992 , pp. 27 - 31
Copyright
Copyright © Elsevier, Paris 1992

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References

Austin, LSLydiard, RBFossey, MDZealberg, JJLaraia, MTBallenger, JC (1990) Panic and phobic disorders in patients with obsessive compulsive disorder J Clin Psychiatry 51, 456–458Google ScholarPubMed
Balon, RPohl, RYeragani, VRainey, JOxenkrug, GF (1987) Platelet serotonin levels in panic disorder Acta Psychiatr Scand 75, 315–317CrossRefGoogle ScholarPubMed
Bailly, DVignau, JLauth, BRacadot, NBeuscart, RServant, DParquet, PJ (1990) Platelet serotonin decrease in alcoholic patients Acta Psychiatr Scand 81, 68–72CrossRefGoogle ScholarPubMed
Black, DWNoyes, R (1990) Comorbidity and obsessivecompulsive disorderIn: Comorbidity of Mood and Anxiety Disorders (Maser, JDCloniger, CR eds) American Psychiatric Press Inc, Washington DC, 305–316Google Scholar
Boyd, JMBurke, JDGruenberg, EHolzer, CERae, DSGeorqe, LKKarno, MStoltman, RMc Evoy, LNestadt, (1984) Exclusion criteria of DSM III. A study of co-occurence of hierarchy free syndromes Arch Gen Psychiatry 41, 983–989CrossRefGoogle Scholar
Breier, ACharney, DSHeninger, GR (1986) Agoraphobia and panic disorder development, diagnostic stability and course of illness Arch Gen Psychiatry 43, 1029–1036CrossRefGoogle ScholarPubMed
Cloninger, CRMartin, RLClayton, P (1981) A blind follow-up and family study of anxiety neurosis: preliminary analysis of the Saint Louis 500In: Anxiety. New Research and Changing Concept (Klein, DFRabkins, J eds) Raven Press, New YorkGoogle Scholar
Cottraux, JFlachaire, ERenaud, B (1987) Dosage de la sérolonine plaquettaire dans les obsessions compulsions Presse Med 16, 590Google Scholar
Dreux, CLaunay, JMGiret, M (1979) The platelet model applied to the study of depressive illness Ann Biol Clin 37, 41–47Google Scholar
Endicott, JSpitzer, RL (1978) A diagnostic interview: the schedule for affective disorders and schizophrenia Arch Gen Psychiatry 35, 837–844CrossRefGoogle Scholar
Fernstrom, JDWurtman, RJ (1972) Brain serotonin content: increase following ingestion of carbohydrate diet Science 174, 1023–1025CrossRefGoogle Scholar
Flament, MFRapoport, JLMurphy, DCBerg, CLLake, CR (1987) Biochemical changes during clomipramine treatment of childhood OCD Arch Gen Psychiatry 44, 219–225CrossRefGoogle Scholar
Hesselbrock, VMHesselbrock, MNWorkman-Daniels, KL (1987) Effects of major depression and anti-social personality on alcoholism: course and motivational patterns J Stud Alcohol 47, 207–212CrossRefGoogle Scholar
Innis, RBCharney, DSHeninger, GR (1987) Differential 3H-imipramine platelet binding in patients with panic disorder and depression Psychiatry Res 21, 33–41CrossRefGoogle ScholarPubMed
Insel, TRMueller, EAAlterman, ILinnoila, MMurphy, DL (1985) Obsessive-compulsive disorder and serotonin: is there a connection? Biol Psychiatry 20, 1174–1188CrossRefGoogle Scholar
Kahn, RSVan Praag, HMWetzler, SAsnis, GMBarr, G (1988) Serotonin and anxiety revisited Biol Psychiatry 23, 189–208CrossRefGoogle Scholar
Mellman, TAUhde, TW (1987) Obsessive-compulsive symptoms in panic disorder Am J Psychiatry 12, 1573–1576Google Scholar
Murphy, DLPigott, TA (1990) A comparative examination of the role for serotonin in obsessive-compulsive disorder, panic disorder, and anxiety J Clin Psychiatry 4 (suppl) 53–58Google Scholar
Norman, TRJudd, FKGregory, MJames, RMKimber, NMMc Intyre, IMBurrow, GD (1986) Platelet serotonin uptake in panic disorder, J Affect Disord 11, 69–72CrossRefGoogle Scholar
Ortiz, JAstigas, FGelpi, E (1988) Serotoninergic status in human blood Life Set 43, 983–990CrossRefGoogle Scholar
Rasmussen, SATsuang, MT (1986) Epidemiology and clinical features of OCDIn: OCD: Theory and Management (Jenike, MABaer, LMinichiellowe, eds) Littleton, PSG Publishing Inc 23–43Google Scholar
Servant, DBailly, DParquet, PJ (1988) Fluvoxamine in the treatment of panic disorder with obsessivecompulsive symptoms Am J Psychiatry 9, 1174–1175Google Scholar
Servant, DBailly, DLeseac’h, HParquet, PJ (1990) Sym ptomes obsessionnels compulsifs assoeiés au trouble panique. Facteur prédictif d’une bonne réponse à la Fluvoxamine L’Encéphule 16, 359–362Google Scholar
Sheehan, DVZak, JPMiller, JABalsam, SLFanous, MD (1988) Panic disorder: The potential role of serotonin reuptake inhibitors J Clin Psychiatry 49, 30–36Google ScholarPubMed
Uhde, TWBerrettini, WHRoy-Byrne, PPBoulenger, JPPost, RM (1987) Platelet (3H) imipramine binding in patients with panic disorder Biol Psychiatry 22, 52–58CrossRefGoogle ScholarPubMed
van Hahn, HPHonegger, GGPletscher, A (1980) Similar kinetic characteristics of 5-HT binding in blood platelets and brain membranes of rats Neurosci 20, 319–322Google Scholar
Weizman, ACarmi, MHermesh, HShahar, AApter, ATyano, SRehavi, M (1986) High affinity imipramine binding and serotonin uptake in platelets of eight adolescents and ten adult obsessive-compulsive patients Am J Psychiatry 143, 335–339Google ScholarPubMed
Zak, JPMiller, JASheehan, DVFanous, BS (1988) The potential role of serotonin reuptake inhibitors in the treatment of obsessive compulsive disorder J Clin Psychiatry 8 (stippl) 23–29Google Scholar
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