Regular timing observations of millisecond and binary pulsars are made with the 64-m radio telescope at Kalyazin (Russia). Filterbank 160-channel receiver is used for observations at 0.6 GHz in two circular orthogonal polarization. Precise local time service (based upon a rubidium standards and hydrogen maser) is used for measurements of Times-of-Arrival (TOA) from radio pulsars. A local time scale is compared by GPS and TV-systems with the basic AT-scales (UTC(USNO) and UTC(SU)) within an accuracy about 50 ns per day. Recently the second 1.4 GHz receiver (250 kHz × 64 channels) was constructed and installed at Kalyazin radio telescope. There is a possibility to combine a part of the 1.4 GHz back-end with the 2.2 GHz front-end to produce timing observations at three frequencies simultaneously. We present a results of precise timing observations conducted by the Kalyazin pulsar system. Most of data were obtained at 0.6 GHz in 1997–1999. The data will be used for valuable applications in fundamental metrology, interstellar medium, general relativity and pulsar physics itself.