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Development of a 70 MHz unit for hyperthermia treatment of deep-seated breast tumors

  • Johannes Crezee (a1), Geertjan Van Tienhoven (a1), Merel W. Kolff (a1), Jan Sijbrands (a1), Gerard Van Stam (a1), Sabine Oldenborg (a1), Elisabeth D. Geijsen (a1), Maarten C.C.M. Hulshof (a1) and Henny P. Kok (a1)...

A dedicated hyperthermia (HT) system was designed for tumors in intact breast extending beyond the heating depth of our superficial 434 MHz antennas, consisting of a treatment bed fitted with a 50 cm × 40 cm × 16 cm temperature controlled open water bolus. The patient lies in prone position with the breast immersed in the water positioned in front of a 34 cm × 20 cm 70 MHz waveguide operating in the TE10 mode. E-field patterns were measured in a tissue-mimicking phantom. HT was applied once a week with the 70 MHz applicator for six patients treated with thermoradiotherapy for deep lesions of recurrent breast cancer or melanoma. Two 14-sensor thermocouple thermometry probes were placed in catheters to monitor the invasive temperature. Results: Phantom measurements showed sufficient penetration depth up to 10 cm depth. The combination of 300–900 W antenna power and a water temperature of 42°C was well tolerated for the entire session of 1 h and resulted in good tumor temperatures with T90 = 39.8°C, T50 = 41.1°C, and T10 = 42.2°C. No toxicity or complaints were associated with the heating. A water mattress and other measures were needed to assure a comfortable position throughout the treatment. Conclusion: the 70 MHz breast applicator system performed well and tumor temperatures were good.

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Corresponding author: J. Crezee Email:
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International Journal of Microwave and Wireless Technologies
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