Hostname: page-component-76fb5796d-vfjqv Total loading time: 0 Render date: 2024-04-25T20:06:54.024Z Has data issue: false hasContentIssue false
  • English
  • Français

Attenuated effect of the apolipoprotein E ɛ4 allele on neuropsychiatric symptoms among African older adults

Published online by Cambridge University Press:  30 March 2021

Claudia K. Suemoto  and
Cleusa P. Ferri Open the ORCID record for Cleusa P. Ferri [Opens in a new window]
Claudia K. Suemoto
Affiliation:
Universidade de Sao Paulo, Division of Geriatrics, Sao Paulo, Brazil
Cleusa P. Ferri*
Affiliation:
Hospital Alemao Oswaldo Cruz, International Research Centre, São Paulo, Brazil Universidade Federal de Sao Paulo, Department of Psychiatry, Sao Paulo, Brazil
*
E-mail: ferricleusa@gmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Commentary
Information
International Psychogeriatrics , Volume 33 , Special Issue 3: Issue Theme: Neuropsychiatric Symptoms in Older Adults with Cognitive Disorders , March 2021 , pp. 213 - 215
Copyright
© International Psychogeriatric Association 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Acosta, I., Borges, G., Aguirre-Hernandez, R., Sosa, A. L. and Prince, M. for the 10/66 Dementia Research Group. (2018). Neuropsychiatric symptoms as risk factors of dementia in a Mexican population: A 10/66 Dementia Research Group study. Alzheimers & Dementia, 14, 271–279.CrossRefGoogle Scholar
Barnes, L. L. and Bennett, D. A. (2014). Alzheimer’s disease in African Americans: risk factors and challenges for the future. Health Affairs (Millwood), 33, 580–586.CrossRefGoogle ScholarPubMed
Brodaty, H. et al. (2012). Neuropsychiatric symptoms in older people with and without cognitive impairment. Journal of Alzheimers Disease, 31, 411–420.CrossRefGoogle ScholarPubMed
Camozzato, A. L., Godinho, C., Kochhann, R., Massochini, G. and Chaves, M. L. (2015). Validity of the Brazilian version of the Neuropsychiatric Inventory Questionnaire (NPI-Q). Arquivos de Neuropsiquiatria 73, 41–45.CrossRefGoogle Scholar
Evans, D. A. et al. (2003). Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status. Archives of Neurology, 60, 185–189.CrossRefGoogle Scholar
Fiske, A., Wetherell, J. L. and Gatz, M. (2009). Depression in older adults. Annual Review of Clinical Psychology, 5, 363–389.CrossRefGoogle ScholarPubMed
Hendrie, H.C. et al. (2014). APOE ɛ4 and the risk for Alzheimer disease and cognitive decline in African Americans and Yoruba. International Psychogeriatrics, 26, 977–985. doi: 10.1017/S1041610214000167.CrossRefGoogle Scholar
Kim, J., Basak, J. M. and Holtzman, D. M. (2009). The role of apolipoprotein E in Alzheimer’s disease. Neuron, 63, 287–303. doi: 10.1016/j.neuron.2009.06.026.CrossRefGoogle ScholarPubMed
Kunkle, B. W. et al. (2020). Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. JAMA Neurology. doi: 10.1001/jamaneurol.2020.3536.Google Scholar
Li, Z., Shue, F., Zhao, N., Shinohara, M. and Bu, G. (2020). APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease. Molecular Neurodegeneration, 15, 63.CrossRefGoogle ScholarPubMed
Lotrich, F. E. (2011). Gene-environment interactions in geriatric depression. The Psychiatric Clinics of North America, 34, 357–376, viii.CrossRefGoogle ScholarPubMed
Mayeda, E. R., Glymour, M. M., Quesenberry, C. P., Johnson, J. K., Perez-Stable, E. J. and Whitmer, R. A. (2017). Survival after dementia diagnosis in five racial/ethnic groups. Alzheimers & Dementia, 13, 761–769.CrossRefGoogle ScholarPubMed
Morris, J. C. et al. (2019). Assessment of Racial Disparities in Biomarkers for Alzheimer Disease. JAMA Neurology, 76, 264–273.CrossRefGoogle ScholarPubMed
Panza, F. et al. (2012). Apolipoprotein E genotypes and neuropsychiatric symptoms and syndromes in late-onset Alzheimer’s disease. Ageing Research Reviews, 11, 87–103.CrossRefGoogle ScholarPubMed
Petkus, A. J., Gatz, M., Reynolds, C. A., Kremen, W. S. and Wetherell, J. L. (2016). Stability of genetic and environmental contributions to anxiety symptoms in older adulthood. Behavior Genetics, 46, 492–505.CrossRefGoogle ScholarPubMed
Pink, A. et al. (2015). Neuropsychiatric symptoms, APOE ɛ4, and the risk of incident dementia: a population-based study. Neurology, 84, 935–943.CrossRefGoogle Scholar
Schlesinger, D. et al. (2013). African ancestry protects against Alzheimer’s disease-related neuropathology. Molecular Psychiatry, 18, 79–85.CrossRefGoogle ScholarPubMed
Sink, K. M., Holden, K. F. and Yaffe, K. (2005). Pharmacological treatment of neuropsychiatric symptoms of dementia - A review of the evidence. JAMA-Journal of the American Medical Association, 293, 596–608.CrossRefGoogle Scholar
Weuve, J. et al. (2018). Cognitive Aging in Black and White Americans: Cognition, Cognitive Decline, and Incidence of Alzheimer Disease Dementia. Epidemiology, 29, 151–159.CrossRefGoogle ScholarPubMed
Yoro-Zohoun, I. et al. (2021). Apolipoprotein E ɛ4 allele and neuropsychiatric symptoms among older adults in Central Africa (EPIDEMCA study). International Psychogeriatrics, 33, 295–306.CrossRefGoogle Scholar