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The AD8 (Dementia Screening Interview) is a valid and reliable screening scale not only for dementia but also for mild cognitive impairment in the Turkish geriatric outpatients

Published online by Cambridge University Press:  20 June 2018

Cansu Usarel ,
Ozge Dokuzlar ,
Ali Ekrem Aydin ,
Pinar Soysal  and
Ahmet Turan Isik
Cansu Usarel
Affiliation:
Unit for Aging Brain and Dementia, Department of Geriatric Medicine, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey
Ozge Dokuzlar
Affiliation:
Department of Geriatric Medicine, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey
Ali Ekrem Aydin
Affiliation:
Department of Geriatric Medicine, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey
Pinar Soysal
Affiliation:
Kayseri Education and Research Hospital, Geriatric Center, Kayseri, Turkey
Ahmet Turan Isik*
Affiliation:
Unit for Aging Brain and Dementia, Department of Geriatric Medicine, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey
*
Correspondence should be addressed to: Ahmet Turan ISIK, M.D., Unit for Aging Brain and Dementia, Department of Geriatric Medicine, Dokuz Eylul University, Faculty of Medicine, 35340, Balcova, Izmir, Turkey. Phone: +90 232 412 43 41; Fax: +90 232 412 43 39. Email: atisik@yahoo.com.
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Abstract

Introduction:

There is still a need for short, practical, and daily-appropriate scales to distinguish between normal cognitive aging, mild cognitive impairment (MCI), or dementia for patients with memory complaints. This study aimed to determine validity and reliability of AD8 (Dementia Screening Interview) to detect both MCI and dementia in Turkish geriatric outpatients.

Methods:

Comprehensive geriatric assessment was performed in 334 patients, who attended with their informants to the geriatric outpatient clinic for memory complaints. In addition to the AD8, they were screened using Clinical Dementia Rating scale (CDR) and Mini-Mental State Examination. The diagnosis of dementia and MCI was made according to the Diagnostic and Statistical Manual of Mental Disorders - fifth edition (DSM-5) criteria.

Results:

The mean age of the patients was 74.5±8.5. Of them, 156 were considered as non-cognitive impairment, 60 as MCI, and 118 as dementia. Cronbach's α value of the AD8 was 0.928. The total AD8 scores were found to be negatively correlated with the MMSE scores (r = −0.801), and positively correlated with CDR score (r = 0.879) (p < 0.001, for each). The area under the receiver-operating characteristics curve was 0.979 for cognitive impairment, and 0.999 for dementia. We found that AD8 can show dementia and MCI when the cut-off values are ≥5 and 3–4, respectively, with a sensitivity of 100% and 81.67% and specificity of 96.3% and 93.59%.

Conclusion:

AD8 is one of the fast, simple, and sensitive screening methods for detecting both minor and major cognitive impairments. With regard to these features, it can be used in older adults attending the primary care settings with memory complaints.

Keywords

cognitive assessmentcognitive impairmentdementiascalesscreening
Type
Original Research Article
Information
International Psychogeriatrics , Volume 31 , Issue 2: Issue Theme: Positive Psychiatry II , February 2019 , pp. 223 - 229
Copyright
Copyright © International Psychogeriatric Association 2018 

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References

American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th edn. Arlington, DC: American Psychiatric Association.Google Scholar
Annoni, J., Chouiter, L. and Demonet, J. (2016). Age-related cognitive impairment: conceptual changes and diagnostic strategies. Revue Médicale Suisse, 12, 774–779.Google Scholar
Babacan-Yıldız, G. et al. (2013). COST: cognitive state test, a brief screening battery for Alzheimer disease in illiterate and literate patients. International Psychogeriatrics, 25, 403–412.10.1017/S1041610212001780Google Scholar
Carnero Pardo, C. et al. (2013). Assessing the diagnostic accuracy (DA) of the Spanish version of the informant-based AD8 questionnaire. Neurologia (Barcelona, Spain), 28, 88–94.10.1016/j.nrl.2012.03.012Google Scholar
Carpenter, C., DesPain, B., Keeling, T., Shah, M. and Rothenberger, M. (2011). The six-item screener and AD8 for the detection of cognitive impairment in geriatric emergency department patients. Annals of Emergency Medicine, 57, 653–661.10.1016/j.annemergmed.2010.06.560Google Scholar
Chin, R., Ng, A., Narasimhalu, K. and Kandiah, N. (2013). Utility of the AD8 as a self-rating tool for cognitive impairment in an Asian population. American Journal of Alzheimer's Disease and Other Dementias, 28, 284–288.10.1177/1533317513481090Google Scholar
Cordell, C. B. et al. (2013). Alzheimer's association recommendations for operationalizing the detection of cognitive impairment during the medicare annual wellness visit in a primary care setting. Alzheimer's and Dementia, 9, 141–150.10.1016/j.jalz.2012.09.011Google Scholar
Dokuzlar, O., Soysal, P., Usarel, C. and Isik, A. T. (2018 In press). The evaluation and design of a short depression screening tool in Turkish older adults. International Psychogeriatrics, 1–8 doi: 10.1017/S1041610218000236 (Epub ahead of print).Google Scholar
Dong, Y., Cheng, T., Tsou, K., Chan, Q. and Chen, C. (2014). Feasibility and acceptability of the informant AD8 for cognitive screening in primary healthcare: a pilot study. Scientific World Journal, 2014, 302834.10.1155/2014/302834Google Scholar
Durmaz, B., Soysal, P., Ellidokuz, H. and Isik, A. T. (2018). Validity and reliability of geriatric depression scale-15 (short form) in Turkish older adults. Northern Clinics of Istanbul. doi: 10.14744/nci.2017.85047.Google Scholar
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.10.1016/0022-3956(75)90026-6Google Scholar
Fritsch, T., McClendon, M. J., Wallendal, M. S., Hyde, T. F. and Larsen, J. D. (2014). Prevalence and cognitive bases of subjective memory complaints in older adults: evidence from a community sample. Journal of Neurodegenerative Diseases, 2014, 17684310.1155/2014/176843Google Scholar
Galvin, J. E. et al. (2005). The AD8: a brief informant interview to detect dementia. Neurology, 65, 559–564.10.1212/01.wnl.0000172958.95282.2aGoogle Scholar
Galvin, J. E., Roe, C. M., Coats, M. A. and Morris, J. C. (2007a). Patient's rating of cognitive ability: using the AD8, a brief informant interview, as a self-rating tool to detect dementia. Archives of Neurology, 64, 725–730.10.1001/archneur.64.5.725Google Scholar
Galvin, J. E., Roe, C. M. and Morris, J. C. (2007b). Evaluation of cognitive impairment in older adults: combining brief informant and performance measures. Archives of Neurology, 64, 718–724.10.1001/archneur.64.5.718Google Scholar
Galvin, J. E., Roe, C. M., Xiong, C. and Morris, J. C. (2006). Validity and reliability of the AD8 informant interview in dementia. Neurology, 67, 1942–1948.10.1212/01.wnl.0000247042.15547.ebGoogle Scholar
Heinik, J. (2010). V. A. Kral and the origins of benign senescent forgetfulness and mild cognitive impairment. International Psychogeriatrics, 22, 395–402.10.1017/S1041610209991682Google Scholar
Inouye, S. K., van Dyck, C. H., Alessi, C. A., Balkin, S., Siegal, A. P. and Horwitz, R. I. (1990). Clarifying confusion: the confusion assessment method. A new method for detection. Annals of Internal Medicine, 113, 941–948.10.7326/0003-4819-113-12-941Google Scholar
Isik, A. T. (2010). Late onset Alzheimer's disease in older people. Clinical Interventions in Aging, 5, 307–311.10.2147/CIA.S11718Google Scholar
Isik, A. T., Soysal, P., Kaya, D. and Usarel, C. (2018). Triple test, a diagnostic observation, can detect the cognitive impairment in older adults. Psychogeriatrics, 18, 98–105.10.1111/psyg.12289Google Scholar
Jonker, C., Geerlings, M. and Schmand, B. (2000). Are memory complaints predictive for dementia? a review of clinical and population-based studies. International Journal of Geriatric Psychiatry, 15, 983–991.10.1002/1099-1166(200011)15:11<983::AID-GPS238>3.0.CO;2-53.0.CO;2-5>Google Scholar
Lawton, M. and Brody, E. (1969). Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist, 9, 179–186.10.1093/geront/9.3_Part_1.179Google Scholar
Li, T., Wang, H., Yang, Y., Galvin, J., Morris, J. and Yu, X. (2012). The reliability and validity of Chinese version of AD8. Zhonghua Nei Ke Za Zhi, 51, 777–780.Google Scholar
Logiudice, D. and Watson, R. (2014). Dementia in older people: an update. Internal Medicine Journal, 44, 1066–1073.10.1111/imj.12572Google Scholar
Mahoney, F. I. and Barthel, D. W. (1965). Functional evaluation: the Barthel index. Maryland State Medical Journal, 14, 61–65.Google Scholar
Malmstrom, T. K., Miller, D. K., Coats, M. A., Jackson, P., Miller, J. P. and Morris, J. C. (2009). Informant-based dementia screening in a population-based sample of African Americans. Alzheimer Disease and Associated Disorders, 23, 117–123.10.1097/WAD.0b013e318190a709Google Scholar
Meguro, K., Kasai, M. and Nakamura, K. (2015). Reliability and validity of the Japanese version of the AD8. Japanese Journal of Geriatrics, 52, 61–70.10.3143/geriatrics.52.61Google Scholar
Morris, J. (1993). The clinical dementia rating (CDR): current version and scoring rules. Neurology, 43, 2412–2414.10.1212/WNL.43.11.2412-aGoogle Scholar
Nasreddine, Z. S. et al. (2005). The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. Journal of the American Geriatrics Society, 53, 695–699.10.1111/j.1532-5415.2005.53221.xGoogle Scholar
Petersen, R. C., Caracciolo, B., Brayne, C., Gauthier, S., Jelic, V. and Fratiglioni, L. (2014). Mild cognitive impairment: a concept in evolution. Journal of Internal Medicine, 275, 214–228.10.1111/joim.12190Google Scholar
Ponds, R., Commissaris, K. and Jolles, J. (1997). Prevalence and covariates of subjective forgetfulness in a normal population in the Netherlands. International Journal of Aging & Human Development, 45, 207–221.10.2190/MVQ1-WB58-875H-Y4X0Google Scholar
Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W. and Ferri, C. (2013). The global prevalence of dementia: a systematic review and metaanalysis. Alzheimer's and Dementia, 9, 63–75.10.1016/j.jalz.2012.11.007Google Scholar
Ryu, H. J., Kim, H. J. and Han, S. H. (2009). Validity and reliability of the Korean version of the AD8 informant interview (K-AD8) in dementia. Alzheimer Disease and Associated Disorders, 23, 371–376.10.1097/WAD.0b013e31819e6881Google Scholar
Shaik, M. A. et al. (2016). The reliability and validity of the informant AD8 by comparison with a series of cognitive assessment tools in primary healthcare. International Psychogeriatrics, 28, 443–452.10.1017/S1041610215001702Google Scholar
Shulman, K. I. (2000). Clock drawing: is it the ideal cognitive screening test? International Journal of Geriatric Psychiatry, 15, 548–561.10.1002/1099-1166(200006)15:6<548::AID-GPS242>3.0.CO;2-U3.0.CO;2-U>Google Scholar
Singh-Manoux, A. et al. (2014). Subjective cognitive complaints and mortality: does the type of complaint matter? Journal of Psychiatric Research, 48, 73–78.10.1016/j.jpsychires.2013.10.005Google Scholar
Soysal, P. et al. (2016). Acetylcholinesterase inhibitors are associated with weight loss in older people with dementia: a systematic review and meta-analysis. Journal of Neurology, Neurosurgery and Psychiatry, 87, 1368–1374.10.1136/jnnp-2016-313660Google Scholar
Soysal, P. and Isik, A. T. (2016). Effects of acetylcholinesterase inhibitors on nutritional status in elderly patients with dementia: a 6-month follow-up study. The Journal of Nutrition, Health & Aging, 20, 398–403.10.1007/s12603-015-0603-zGoogle Scholar
Soysal, P., Usarel, C., Ispirli, G. and Isik, A. T. (2017). Attended with and head-turning sign can be clinical markers of cognitive impairment in older adults. International Psychogeriatrics, 29, 1763–1769.10.1017/S1041610217001181Google Scholar
Tariq, S. H., Tumosa, N., Chibnall, J. T., Perry, M. H. and Morley, J. E. (2006). Comparison of the Saint Louis University mental status examination and the mini-mental state examination for detecting dementia and mild neurocognitive disorder–a pilot study. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 14, 900–910.10.1097/01.JGP.0000221510.33817.86Google Scholar
Xie, Y., Gao, Y., Jia, J., Wang, X., Wang, Z. and Xie, H. (2014). Utility of AD8 for cognitive impairment in a Chinese physical examination population: a preliminary study. Scientific World Journal, 2014, 804871.10.1155/2014/804871Google Scholar
Yang, Y. H., Galvin, J. E., Morris, J. C., Lai, C. L., Chou, M. C. and Liu, C. K. (2011). Application of AD8 questionnaire to screen very mild dementia in Taiwanese. American Journal of Alzheimer's Disease and Other Dementias, 26, 134–138.10.1177/1533317510397330Google Scholar