Sørensen, Lauge Igel, Christian Pai, Akshay Balas, Ioana Anker, Cecilie Lillholm, Martin and Nielsen, Mads 2017. Differential diagnosis of mild cognitive impairment and Alzheimer's disease using structural MRI cortical thickness, hippocampal shape, hippocampal texture, and volumetry. NeuroImage: Clinical, Vol. 13, p. 470.
Albrecht, Matthew A. Masters, Colin L. Ames, David and Foster, Jonathan K. 2016. Impact of Mild Head Injury on Neuropsychological Performance in Healthy Older Adults: Longitudinal Assessment in the AIBL Cohort. Frontiers in Aging Neuroscience, Vol. 8,
Anderson, Eric D. Wahoske, Michelle Huber, Mary Norton, Derek Li, Zhanhai Koscik, Rebecca L. Umucu, Emre Johnson, Sterling C. Jones, Jana Asthana, Sanjay and Gleason, Carey E. 2016. Cognitive variability—A marker for incident MCI and AD: An analysis for the Alzheimer's Disease Neuroimaging Initiative. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol. 4, p. 47.
Andrews, K. Abigail Frost, Chris Modat, Marc Cardoso, M. Jorge Rowe, Chris C. Villemagne, Victor Fox, Nick C. Ourselin, Sebastien and Schott, Jonathan M. 2016. Acceleration of hippocampal atrophy rates in asymptomatic amyloidosis. Neurobiology of Aging, Vol. 39, p. 99.
Ashish, Naveen Bhatt, Priya and Toga, Arthur W. 2016. Global Data Sharing in Alzheimer Disease Research. Alzheimer Disease & Associated Disorders, Vol. 30, Issue. 2, p. 160.
Buckley, Rachel F. Maruff, Paul Ames, David Bourgeat, Pierrick Martins, Ralph N. Masters, Colin L. Rainey-Smith, Stephanie Lautenschlager, Nicola Rowe, Christopher C. Savage, Greg Villemagne, Victor L. and Ellis, Kathryn A. 2016. Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease. Alzheimer's & Dementia, Vol. 12, Issue. 7, p. 796.
Buckley, Rachel F. Laming, Gemma Chen, Li Peng Evelyn Crole, Alice Hester, Robert and Motes, Michael A 2016. Assessing Error Awareness as a Mediator of the Relationship between Subjective Concerns and Cognitive Performance in Older Adults. PLOS ONE, Vol. 11, Issue. 11, p. e0166315.
Burnham, Samantha C Bourgeat, Pierrick Doré, Vincent Savage, Greg Brown, Belinda Laws, Simon Maruff, Paul Salvado, Olivier Ames, David Martins, Ralph N Masters, Colin L Rowe, Christopher C and Villemagne, Victor L 2016. Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study. The Lancet Neurology, Vol. 15, Issue. 10, p. 1044.
Cerin, Ester Rainey-Smith, Stephanie R. Ames, David Lautenschlager, Nicola T. Macaulay, S. Lance Fowler, Christopher Robertson, Joanne S. Rowe, Christopher C. Maruff, Paul Martins, Ralph N. Masters, Colin L. and Ellis, Kathryn A. 2016. Associations of neighborhood environment with brain imaging outcomes in the AIBL cohort. Alzheimer's & Dementia,
Crawford, Karen L. Neu, Scott C. and Toga, Arthur W. 2016. The Image and Data Archive at the Laboratory of Neuro Imaging. NeuroImage, Vol. 124, p. 1080.
Donohue, Michael C. Sun, Chung-Kai Raman, Rema Insel, Philip S. and Aisen, Paul S. 2016. Cross-validation of optimized composites for preclinical Alzheimer. Alzheimer's & Dementia: Translational Research & Clinical Interventions,
Evered, Lisbeth A. Silbert, Brendan S. Scott, David A. Maruff, Paul and Ames, David 2016. Prevalence of Dementia 7.5 Years after Coronary Artery Bypass Graft Surgery. Anesthesiology, Vol. 125, Issue. 1, p. 62.
Gu, Ben J. Huang, Xin Ou, Amber Rembach, Alan Fowler, Christopher Avula, Pavan K. Horton, Adam Doecke, James D. Villemagne, Victor L. Macaulay, S. Lance Maruff, Paul Fletcher, Erica L. Guymer, Robyn Wiley, James S. and Masters, Colin L. 2016. Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer’s disease. Acta Neuropathologica, Vol. 132, Issue. 3, p. 377.
Gupta, Veer Bala Doecke, James D. Hone, Eugene Pedrini, Steve Laws, Simon M. Thambisetty, Madhav Bush, Ashley I. Rowe, Christopher C. Villemagne, Victor L. Ames, David Masters, Colin L. Macaulay, Stuart Lance Rembach, Alan Rainey-Smith, Stephanie R. and Martins, Ralph N. 2016. Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol. 3, p. 18.
Hare, Dominic J. Faux, Noel G. Roberts, Blaine R. Volitakis, Irene Martins, Ralph N. and Bush, Ashley I. 2016. Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. Metallomics, Vol. 8, Issue. 6, p. 628.
Harrington, Karra D. Gould, Emma Lim, Yen Ying Ames, David Pietrzak, Robert H. Rembach, Alan Rainey-Smith, Stephanie Martins, Ralph N. Salvado, Olivier Villemagne, Victor L. Rowe, Christopher C. Masters, Colin L. and Maruff, Paul 2016. Amyloid burden and incident depressive symptoms in cognitively normal older adults. International Journal of Geriatric Psychiatry,
Heffernan, Amy L. Chidgey, Cameron Peng, Po Masters, Colin L. and Roberts, Blaine R. 2016. The Neurobiology and Age-Related Prevalence of the ε4 Allele of Apolipoprotein E in Alzheimer’s Disease Cohorts. Journal of Molecular Neuroscience, Vol. 60, Issue. 3, p. 316.
Insel, Philip S. Donohue, Michael C. Mackin, R. Scott Aisen, Paul S. Hansson, Oskar Weiner, Michael W. and Mattsson, Niklas 2016. Cognitive and functional changes associated with Aβ pathology and the progression to mild cognitive impairment. Neurobiology of Aging, Vol. 48, p. 172.
Lim, Yen Ying Laws, Simon M. Villemagne, Victor L. Pietrzak, Robert H. Porter, Tenielle Ames, David Fowler, Christopher Rainey-Smith, Stephanie Snyder, Peter J. Martins, Ralph N. Salvado, Olivier Bourgeat, Pierrick Rowe, Christopher C. Masters, Colin L. and Maruff, Paul 2016. Aβ-related memory decline inAPOEε4 noncarriers. Neurology, Vol. 86, Issue. 17, p. 1635.
Lim, Yen Ying Villemagne, Victor L. Laws, Simon M. Pietrzak, Robert H. Ames, David Fowler, Christopher Rainey-Smith, Stephanie Snyder, Peter J. Bourgeat, Pierrick Martins, Ralph N. Salvado, Olivier Rowe, Christopher C. Masters, Colin L. and Maruff, Paul 2016. Performance on the Cogstate Brief Battery Is Related to Amyloid Levels and Hippocampal Volume in Very Mild Dementia. Journal of Molecular Neuroscience, Vol. 60, Issue. 3, p. 362.
Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of aging aimed to recruit 1000 individuals aged over 60 to assist with prospective research into Alzheimer's disease (AD). This paper describes the recruitment of the cohort and gives information about the study methodology, baseline demography, diagnoses, medical comorbidities, medication use, and cognitive function of the participants.
Methods: Volunteers underwent a screening interview, had comprehensive cognitive testing, gave 80 ml of blood, and completed health and lifestyle questionnaires. One quarter of the sample also underwent amyloid PET brain imaging with Pittsburgh compound B (PiB PET) and MRI brain imaging, and a subgroup of 10% had ActiGraph activity monitoring and body composition scanning.
Results: A total of 1166 volunteers were recruited, 54 of whom were excluded from further study due to comorbid disorders which could affect cognition or because of withdrawal of consent. Participants with AD (211) had neuropsychological profiles which were consistent with AD, and were more impaired than participants with mild cognitive impairment (133) or healthy controls (768), who performed within expected norms for age on neuropsychological testing. PiB PET scans were performed on 287 participants, 100 had DEXA scans and 91 participated in ActiGraph monitoring.
Conclusion: The participants comprising the AIBL cohort represent a group of highly motivated and well-characterized individuals who represent a unique resource for the study of AD. They will be reassessed at 18-month intervals in order to determine the predictive utility of various biomarkers, cognitive parameters and lifestyle factors as indicators of AD, and as predictors of future cognitive decline.
This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.
Email your librarian or administrator to recommend adding this journal to your organisation's collection.
Full text views reflects the number of PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views.
Abstract views reflect the number of visits to the article landing page.
* Views captured on Cambridge Core between September 2016 - 19th August 2017. This data will be updated every 24 hours.