Skip to main content
    • Aa
    • Aa

A case in which mirtazapine reduced auditory hallucinations in a patient with Parkinson disease

  • Tomoyuki Nagata (a1), Shunichiro Shinagawa (a1), Kenji Tagai (a1) and Kazuhiko Nakayama (a1)

A 48-year-old woman with Parkinson disease (PD) suffered from auditory hallucinations (AH). We had treated her with a reduction in antiparkinsonian agents and the use of atypical antipsychotic agents. However, her symptoms did not improve, and her extrapyramidal symptoms (EPS) worsened. To lessen her depressive symptoms, treatment with a new-generation antidepressant, mirtazapine (MRZ), was commenced. The patient's AH gradually decreased with no worsening of EPS, and the AH disappeared 4 weeks after the commencement of treatment with MRZ. The present case suggests the effectiveness of MRZ for the treatment of refractory AHs in patients with PD.

Corresponding author
Correspondence should be addressed to: Tomoyuki Nagata, Department of Psychiatry, Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan. Phone: +81 334 331 111; Fax: +81 334 370 228. Email:
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

G. Fénelon (2008). Psychosis in Parkinson's disease: phenomenology, frequency, risk factors, and current understanding of pathophysiologic mechanisms. CNS Spectrums, 13, 1825.

R. Inzelberg , S. Kipervasser and A. D. Korczyn (1998). Auditory hallucinations in Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 64, 533535.

G. Meco and S. Bernardi (2007). Antidepressant use in treatment of psychosis with comorbid depression in Parkinson's disease. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 31, 311313.

C. Normann et al. (1997). Psychosis during chronic levodopa therapy triggered by the new antidepressive drug mirtazapine. Pharmacopsychiatry, 30, 263265.

B. Ravina et al. (2007). Diagnostic criteria for psychosis in Parkinson's disease: report of an NINDS, NIMH work group. Movement Disorders, 22, 10611068.

L. B. Zahodne and Fernandez , H. H. (2008). Pathophysiology and treatment of psychosis in Parkinson's disease: a review. Drugs and Aging, 25, 665682.

J. Zoldan , G. Friedberg , M. Livneh and E. Melamed (1995). Psychosis in advanced Parkinson's disease: treatment with ondansetron, a 5-HT3 receptor antagonist. Neurology, 45, 13051308.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

International Psychogeriatrics
  • ISSN: 1041-6102
  • EISSN: 1741-203X
  • URL: /core/journals/international-psychogeriatrics
Please enter your name
Please enter a valid email address
Who would you like to send this to? *



Altmetric attention score

Full text views

Total number of HTML views: 3
Total number of PDF views: 16 *
Loading metrics...

Abstract views

Total abstract views: 129 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 26th May 2017. This data will be updated every 24 hours.