Skip to main content
×
×
Home

Dementia clinical trial implications of mild behavioral impairment

  • Moyra E. Mortby (a1) (a2), Sandra E. Black (a3), Serge Gauthier (a4), David Miller (a5), Anton Porsteinsson (a6), Eric E. Smith (a7) (a8) and Zahinoor Ismail (a7) (a8) (a9)...
Extract

The World Alzheimer Report 2016 estimated that 47 million people are living with dementia worldwide (Alzheimer's Disease International, 2016). In the inaugural World Health Organization Ministerial Conference on Global Action against Dementia, six of the top ten research priorities were focused on prevention, identification, and reduction of dementia risk, and on delivery and quality of care for people with dementia and their carers (Shah et al., 2016). While the Lancet Neurology Commission has suggested that even minor advances to delay progression or ameliorate symptoms might have substantial financial and societal benefits (Winblad et al., 2016), advances have been slow.

Copyright
Corresponding author
Email: zahinoor@gmail.com
References
Hide All
Almeida, O., Hankey, G., Yeap, B., Golledge, J. and Flicker, L. (2017). Depression as a modifiable factor to decrease the risk of dementia. Translational Psychiatry, 7, e1117.
Babulal, G. M. et al. (2016). Mood changes in cognitively normal older adults are linked to Alzheimer disease biomarker levels. The American Journal of Geriatric Psychiatry, 24, 10951104.
Banzi, R., Camaioni, P., Tettamanti, M. and Lucca, U. (2016). Older patients are still under-represented in clinical trials of Alzheimer's disease. Alzheimer's Research & Therapy, 8, 32.
Del Campo, N. et al. (2016). Relationship of regional brain β-amyloid to gait speed. Neurology, 86, 3643.
Desmarais, P., Lanctôt, K. L., Masellis, M., Black, S. E. and Herrmann, N. (2017). Social inappropriateness in neurodegenerative disorders. International Psychogeriatrics, 111. doi:10.1017/S1041610217001260
Donovan, N. J. et al. (2014). Regional cortical thinning predicts worsening apathy and hallucinations across the Alzheimer disease spectrum. The American Journal of Geriatric Psychiatry, 22, 11681179.
Fargo, K. N., Carrillo, M. C., Weiner, M. W., Potter, W. Z. and Khachaturian, Z. (2016). The crisis in recruitment for clinical trials in Alzheimer's and dementia: an action plan for solutions. Alzheimer's & Dementia, 12, 11131115.
Fernández-Matarrubia, M., Matias-Guiu, J., Moreno-Ramos, T. and Matias-Guiu, J. (2015). Biomarkers: a new approach to behavioural variant frontotemporal dementia. Neurología (English Edition), 30, 5061.
Fischer, C. E. and Agüera-Ortiz, L. (2017). Psychosis and dementia: risk factor, prodrome, or cause? International Psychogeriatrics, 111. doi:10.1017/S1041610217000874
Gauthier, S. et al. (2016). Why has therapy development for dementia failed in the last two decades? Alzheimer's & Dementia, 12, 6064.
Graham, W. V., Bonito-Oliva, A. and Sakmar, T. P. (2017). Update on Alzheimer's disease therapy and prevention strategies. Annual Review of Medicine, 68, 413430.
Hellmuth, J. et al. (2012). Multicenter validation of a bedside antisaccade task as a measure of executive function. Neurology, 78, 18241831.
Alzheimer's Disease International (2016). World Alzheimer's report.
Ismail, Z. and Mortby, M. E. (2017). Cognitive and neuropsychiatric screening tests in older adults. In Chiu, H. and Shulman, K. (eds.), Mental Health and Illness of the Elderly. New Delhi: Springer.
Ismail, Z. et al. (2016). Neuropsychiatric symptoms as early manifestations of emergent dementia: provisional diagnostic criteria for mild behavioral impairment. Alzheimer's & Dementia, 12, 195202.
Ismail, Z. et al. (2017a). The mild behavioral impairment checklist (MBI-C): a rating scale for neuropsychiatric symptoms in pre-dementia populations. Journal of Alzheimer's Disease, 56, 929938.
Ismail, Z. et al. (2017b). Affective and emotional dysregulation as pre-dementia risk markers: exploring the mild behavioral impairment symptoms of depression, anxiety, irritability, and euphoria. International Psychogeriatrics, 112. doi:10.1017/S1041610217001880
Jalal, H., Ganesh, A., Lau, R., Lysack, J. and Ismail, Z. (2014). Cholinesterase-inhibitor associated mania: a case report and literature review. The Canadian Journal of Neurological Sciences, 41, 278280.
Kwan-Chun Ting, W., Fischer, C. E., Millikin, C. P., Ismail, Z., Chow, T. W. and Schweizer, T. A. (2015). Grey matter atrophy in mild cognitive impairment/early Alzheimer disease associated with delusions: a voxel-based morphometry study. Current Alzheimer Research, 12, 165172.
Ladas, A., Frantzidis, C., Bamidis, P. and Vivas, A. B. (2014). Eye blink rate as a biological marker of mild cognitive impairment. International Journal of Psychophysiology, 93, 1216.
Lanctôt, K. L. et al. (2016). Apathy associated with neurocognitive disorders: recent progress and future directions. Alzheimer's & Dementia.
Lin, F. R., Metter, E. J., O'Brien, R. J., Resnick, S. M., Zonderman, A. B. and Ferrucci, L. (2011). Hearing loss and incident dementia. Archives of Neurology, 68, 214220.
Mortby, M. E. and Anstey, K. J. (2015). Mental health and aging. In Pachana, A. N. (ed.), Encyclopedia of Geropsychology (pp. 16). Singapore: Springer Singapore.
Nagata, T., Kobayashi, N., Shinagawa, S., Yamada, H., Kondo, K. and Nakayama, K. (2014). Plasma BDNF levels are correlated with aggressiveness in patients with amnestic mild cognitive impairment or Alzheimer disease. Journal of Neural Transmission, 121, 433441.
Ng, K. et al. (2017). Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer's disease. Neurology, 88, 18141821.
Peters, K. et al. (2006). Characterizing neuropsychiatric symptoms in subjects referred to dementia clinics. Neurology, 66, 523528.
Shah, H. et al. (2016). Research priorities to reduce the global burden of dementia by 2025. The Lancet Neurology, 15, 12851294.
Sheikh, F. et al. (2017). Prevalence of mild behavioral impairment in mild cognitive impairment and subjective cognitive decline, and its association with caregiver burden. International Psychogeriatrics. doi:10.1017/S104161021700151X
Sherman, C., Liu, C. S., Herrmann, N. and Lanctôt, K. L. (2017). Prevalence, neurobiology, and treatments for apathy in prodromal dementia. International Psychogeriatrics, 18. doi:10.1017/S1041610217000527
Singh-Manoux, A. et al. (2017). Trajectories of depressive symptoms before diagnosis of dementia: a 28-year follow-up study. JAMA Psychiatry, 74, 712718. doi:10.1001/jamapsychiatry.2017.0660
Stanciu, I., Larsson, M., Nordin, S., Adolfsson, R., Nilsson, L.-G. and Olofsson, J. K. (2014). Olfactory impairment and subjective olfactory complaints independently predict conversion to dementia: a longitudinal, population-based study. Journal of the International Neuropsychological Society, 20, 209217.
Tapiainen, V., Hartikainen, S., Taipale, H., Tiihonen, J. and Tolppanen, A.-M. (2017). Hospital-treated mental and behavioral disorders and risk of Alzheimer's disease: a nationwide nested case-control study. European Psychiatry, 43, 9298.
Ting, C. et al. (2010). Differentiating the cognitive profile of schizophrenia from that of Alzheimer disease and depression in late life. PLoS One, 5, e10151.
Winblad, B. et al. (2016). Defeating Alzheimer's disease and other dementias: a priority for European science and society. The Lancet Neurology, 15, 455.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

International Psychogeriatrics
  • ISSN: 1041-6102
  • EISSN: 1741-203X
  • URL: /core/journals/international-psychogeriatrics
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed