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Estimation of the risk of conversion of mild cognitive impairment of Alzheimer type to Alzheimer's disease in a south Brazilian population-based elderly cohort: the PALA study

Published online by Cambridge University Press:  17 November 2011

Cláudia Godinho ,
Ana Luiza Camozzato ,
Diego Onyszko  and
Márcia Lorena Chaves
Cláudia Godinho
Affiliation:
Dementia Clinic, Neurology Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil UFRGS School of Medicine, Porto Alegre, Brazil
Ana Luiza Camozzato
Affiliation:
Dementia Clinic, Neurology Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil
Diego Onyszko
Affiliation:
Dementia Clinic, Neurology Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
Márcia Lorena Chaves*
Affiliation:
Dementia Clinic, Neurology Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil UFRGS School of Medicine, Porto Alegre, Brazil Internal Medicine Department, UFRGS School of Medicine, Porto Alegre, Brazil
*
Correspondence should be addressed to: Márcia L. F. Chaves, Rua Ramiro Barcelos, 2350/ sala 2040, 90035-091, Porto Alegre, RS, Brasil. Phone: +55 51 2101.8520; Fax: +55 51 2101.8001. Email: mchaves@hcpa.ufrgs.br.
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Abstract

Background: Higher mild cognitive impairment (MCI) prognostic variability has been related to sample characteristics (community-based or specialized clinic) and to diverse operationalization criteria. The aim of the study was to evaluate the trajectory of MCI of Alzheimer type in a population-based elderly cohort in Southern Brazil. We also estimated the risk for the development of probable Alzheimer's disease (AD) in comparison with healthy subjects.

Methods: Data were derived from a population-based cohort (the PALA study). MCI outcomes were sub-classified into three categories: conversion, stabilization, and reconversion. The risk of progression to dementia was compared between MCI and normal participants. The analysis was based on 21 MCI subjects and 220 cognitively intact participants (N = 241).

Results: Of the 21 MCI subjects, 38% developed dementia, 24% remained stable and 38% improved. The MCI annual conversion rate to AD was 8.5%. MCI was associated with significantly higher risk of conversion to AD (HR = 49.83, p = 0.004), after adjustment for age, education, sex and Mini-Mental State Examination score.

Conclusions: Independent of the heterogeneity of the outcomes, MCI of the Alzheimer type participants showed significantly higher risk of developing probable AD, demonstrating the impact of the use of these MCI criteria that emphasize long-term episodic memory impairment.

Keywords

mild cognitive impairmentmild cognitive impairment of Alzheimer typeconversion rateprodromal ADAlzheimer's disease

Information

Type
Research Article
Information
International Psychogeriatrics , Volume 24 , Issue 4 , April 2012 , pp. 674 - 681
Copyright
Copyright © International Psychogeriatric Association 2011

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