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Language impairment in euthymic, elderly patients with bipolar disorder but no dementia

  • Marcia Radanovic (a1), Paula Villela Nunes (a1), Wagner Farid Gattaz (a1) and Orestes Vicente Forlenza (a1)
  • DOI:
  • Published online: 01 August 2008

Background: Neurocognitive impairment is known to occur in euthymic bipolar patients, but language alterations have not been thoroughly investigated. The aim of this study is to examine the performance in language tests of a sample of elderly patients with bipolar disorder.

Methods: We studied 33 euthymic elderly patients with bipolar disorder but no dementia and 33 healthy individuals, matched for age and education, who were compared in terms of their CAMCOG global score and its subitems.

Results: The scores obtained in language-related abilities for patients and controls, respectively, were: language (total): 27.3 (1) and 28.5 (1), p < 0.0001; comprehension: 8.6 (0.5) and 8.9 (0.3), p = 0.006; production: 18.7 (1) and 19.6 (0.9), p = <0.0001; abstraction: 6.8 (1.1) and 7.3 (0.7), p = 0.016; verbal fluency: 16.3 (4.3) and 19.6 (4.1), p = 0.003.

Conclusion: A mild but significant impairment in language-related ability scores was detected when comparing patients and controls.

Corresponding author
Correspondence should be addressed to: Marcia Radanovic, Rua Cristiano Viana, 163 ap. 92, São Paulo – SP –Brazil05411-000. Phone: +55 11 30889708; Fax: +55 11 30889708. Email:;
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

C. E. Bearden , K. M. Hoffman and T. D. Cannon (2001). The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review. Bipolar Disorders, 3, 106150.

J. T. O. Cavanagh , M. Van Beck , W. Muir and D. H. R. Blackwood (2002). Case-control study of neurocognitive function in euthymic patients with bipolar disorder: an association with mania. British Journal of Psychiatry, 180, 320326.

H. H. Chen (2004). Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder: a magnetic resonance imaging study. Neuroscience Letters, 363, 6568.

T. Deckersbach (2006). Impaired recruitment of the dorsolateral prefrontal cortex and hippocampus during encoding in bipolar disorder. Biological Psychiatry, 59, 138146.

C. A. Depp and D. V. Jeste (2004). Bipolar disorder in older adults: a critical review. Bipolar Disorders, 6, 343367.

D. E. Fleck (2003). Verbal memory in mania: effects of clinical state and task requirements. Bipolar Disorders, 5, 375380.

A. G. Gildengers (2004). Cognitive functioning in late-life bipolar disorder. American Journal of Psychiatry, 161, 736738.

M. Hamilton (1960). A rating scale for depression. Journal of Neurology, Neurosurgery, and Psychiatry, 23, 5662.

J. M. Harkavy-Friedman (2006). Are BPI and BPII suicide attempters distinct neuropsychologically? Journal of Affective Disorders, 94, 255259.

P. D. Harvey , P. Powchik , M. Parrella , L. White and M. Davidson (1997). Symptom severity and cognitive impairment in chronically hospitalised geriatric patients with affective disorders. British Journal of Psychiatry, 170, 369374.

L. V. Kessing and F. M. Nilsson (2003). Increased risk of developing dementia in patients with major affective disorders compared to patients with other medical illnesses. Journal of Affective Disorders, 73, 261269.

L. V. Kessing and P. K. Andersen (2004). Does the risk of developing dementia increase with the number of episodes in patients with depressive disorder and in patients with bipolar disorder? Journal of Neurology, Neurosurgery, and Psychiatry, 75, 16621666.

A. Martinez-Aran (2004)a. Cognitive impairment in euthymic bipolar patients: implications for clinical and functional outcome. Bipolar Disorders, 6, 224232.

A. Martinez-Aran (2004)b. Cognitive function across manic or hypomanic, depressed, and euthymic states in bipolar disorder. American Journal of Psychiatry, 161, 262270.

A. L. Olley , G. S. Malhi , J. Bachelor , C. M. Cahill , P. B. Mitchell and M. Berk (2005). Executive functioning and theory of mind in euthymic bipolar disorder. Bipolar Disorders, 7 (Suppl 5), 4352.

L. J. Robinson (2006). A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. Journal of Affective Disorders, 93, 105115.

M. Roth (1986). CAMDEX: a standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. British Journal of Psychiatry, 149, 698709.

S. M. Strakowski , M. P. Delbello and C. M. Adler (2005). The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings. Molecular Psychiatry, 10, 105116.

J. M. Thompson (2005). Neurocognitive impairment in euthymic patients with bipolar affective disorder. British Journal of Psychiatry, 186, 3240.

W. G. van Gorp , L. Altshuler , D. C. Theberge , J. Wilkins and W. Dixon (1998). Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence: a preliminary study. Archives of General Psychiatry, 55, 4146.

W. G. van Gorp , L. Altshuler , D. C. Theberge and J. Mintz (1999). Declarative and procedural memory in bipolar disorder. Biological Psychiatry, 46, 525531.

R. C. Young , J. T. Biggs , V. E. Ziegler and D. A. Meyer (1978). A rating scale for mania: reliability, validity and sensitivity. British Journal of Psychiatry, 133, 429435.

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International Psychogeriatrics
  • ISSN: 1041-6102
  • EISSN: 1741-203X
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