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Subjective cognitive impairment and quality of life: a systematic review

  • Nikki L. Hill (a1), Caroline McDermott (a1), Jacqueline Mogle (a1), Elizabeth Munoz (a2), Nicole DePasquale (a3), Rachel Wion (a1) and Emily Whitaker (a1)...



Older adults with subjective cognitive impairment (SCI) experience increased affective symptoms, reduced engagement in a range of activities, as well as more functional problems when compared to those without SCI. These associations suggest that SCI may be detrimental to older adults’ quality of life (QoL). The purpose of this paper is to advance understanding of the SCI–QoL relationship through a comprehensive review of the empirical literature relating SCI and QoL.


A systematic literature review was conducted in CINAHL, PsycINFO, and PubMed per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. Eligible articles were appraised using the weight of evidence (WoE) framework to evaluate methodological quality, methodological relevance, and topic relevance. A narrative synthesis of results was conducted, based on conceptual definitions of QoL.


Eleven articles were identified that met eligibility criteria. WoE ratings ranged from low to high scores. Studies reviewed reported that the presence, greater frequency, or greater severity of SCI is associated with lower QoL regardless of methodological quality rating, sample characteristics (e.g. geographic location, clinical vs. community settings), study design (e.g. cross-sectional vs. longitudinal), and operationalization of SCI or QoL.


Across studies, QoL was negatively associated with SCI. However, a frequent limitation of the reviewed literature was the mismatch between the conceptual and operational definitions of SCI and QoL. Similarly, SCI measures varied in quality across the reviewed literature. This suggests future empirical work should focus on the appropriate strategies for conceptually and operationally defining these constructs.


Corresponding author

Correspondence should be addressed to: Nikki L. Hill, College of Nursing, The Pennsylvania State University, 201 Nursing Sciences Building, University Park, PA 16802, USA. Phone: +(814) 867-3265; Fax: +814-863-1027. Email:


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Baernholdt, M., Hinton, I., Yan, G., Rose, K. and Mattos, M. (2012). Factors associated with quality of life in older adults in the United States. Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, 21, 527534. doi:10.1007/s11136-011-9954-z
Bilotta, C. et al. (2011). Older People's Quality of Life (OPQOL) scores and adverse health outcomes at a one-year follow-up. A prospective cohort study on older outpatients living in the community in Italy. Health and Quality of Life Outcomes, 9, 72. doi:10.1186/1477-7525-9-72
Bowling, A., Seetai, S., Morris, R. and Ebrahim, S. (2007). Quality of life among older people with poor functioning. The influence of perceived control over life. Age and Ageing, 36, 310315.
Castro-Lionard, K. et al. (2011). Can maintaining cognitive function at 65 years old predict successful ageing 6 years later? The PROOF study. Age and Ageing, 40, 259265. doi:10.1093/ageing/afq174
Centers for Disease Control and Prevention. (2016). Well-being concepts. Centers for Disease Control and Prevention, [website]. Available at:; last accessed 22 May 2017.
Comijs, H. C., Deeg, D. J., Dik, M. G., Twisk, J. W., and Jonker, C. (2002). Memory complaints; the association with psycho-affective and health problems and the role of personality characteristics. A 6-year follow-up study. Journal of Affective Disorders, 72, 157165. doi: 10.1016/S0165-0327(01)00453-0
Corner, L. and Bond, J. (2004). Being at risk of dementia: fears and anxieties of older adults. Journal of Aging Studies, 18, 143155. doi:10.1016/j.jaging.2004.01.007
Derouesné, C. et al. (1989). Memory complaints in the elderly: a study of 367 community-dwelling individuals from 50 to 80 years old. Archives of Gerontology and Geriatrics. Supplement, 1, 151163.
Derouesné, C., Lacomblez, L., Thibault, S. and Leponcin, M. (1999). Memory complaints in young and elderly subjects. International Journal of Geriatric Psychiatry, 14, 291301. doi: 10.1002/(SICI)1099-1166(199904)14:4<291::AID-GPS902>3.0.CO; 27.
Diener, E., Emmons, R. A., Larsen, R. J. and Griffin, S. (1985). The Satisfaction with life scale. Journal of Personality Assessment, 49, 7175. doi:10.1207/s15327752jpa4901_13
Diener, E. and Suh, E. M. (1998). Subjective well-being and age: An international analysis. In Schaie, K. W. and Lawton, M. P. (eds.), Annual Review of Gerontology and Geriatrics (Focus on emotion and adult development, Vol. 17, pp. 304324). New York: Springer.
dos Santos, A. T., Leyendecker, D. D., Costa, A. L. and de Souza-Talarico, J. N. (2012). Subjective memory complain in healthy elderly: Influence of depressive symptoms, perceived stress and self-esteem. Revista da Escola de Enfermagem da U S P, 46 Spec No, 24–29.
Fastame, M. C., Penna, M. P. and Rossetti, E. S. (2014). Perceived cognitive efficiency and subjective well-being in late adulthood: the impact of developmental factors. Journal of Adult Development, 21, 173180. doi:10.1007/s10804-014-9189-7
Fayers, P. M. and Machin, D. (2013). Quality of Life: The Assessment, Analysis and Interpretation of Patient-reported Outcomes. West Sussex, England: John Wiley & Sons.
Gobbens, R. J. J. and van Assen, M. A. L. M. (2014). The prediction of quality of life by physical, psychological and social components of frailty in community-dwelling older people. Quality of Life Research, 23, 22892300.
Gough, D. (2007). Weight of evidence: a framework for the appraisal of the quality and relevance of evidence. Research Papers in Education, 22, 213228. doi:10.1080/02671520701296189
Grabowski, A. and Broemer, P. (2015). Temporal self-extension: implications for temporal comparison and autobiographical memory. Polish Psychological Bulletin, 46, 246261. doi:10.1515/ppb-2015-0033
Hill, N. L. et al. (2016). Subjective cognitive impairment and affective symptoms: a systematic review. Gerontologist, 56, e109e127. doi:10.1093/geront/gnw091
Jessen, F. et al. (2014). A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimers Dement, 10, 844852. doi:10.1016/j.jalz.2014.01.001
Jonker, C., Geerlings, M. I. and Schmand, B. (2000). Are memory complaints predictive for dementia? A review of clinical and population-based studies. International Journal of Geriatric Psychiatry, 15, 983991. doi:10.1002/1099-1166(200011)15:11%3C983::AID-GPS238%3E3.0.CO, 25
Kessler, E.-M., Bowen, C. E., Baer, M., Froelich, L. and Wahl, H.-W. (2012). Dementia worry: a psychological examination of an unexplored phenomenon. European Journal of Ageing, 9, 275284. doi:10.1007/s10433-012-0242-8
Kim, J., Im, J. S. and Choi, Y. H. (2016). Objectively measured sedentary behavior and moderate-to-vigorous physical activity on the health-related quality of life in US adults: the national health and nutrition examination survey 2003–2006. Quality of Life Research, 112. doi: 10.1007/s11136-016-1451-y
Maki, Y. et al. (2014). The impact of subjective memory complaints on quality of life in community-dwelling older adults. Psychogeriatrics, 14(, 175181. doi:10.1111/psyg.12056
Mitchell, A. J., Kemp, S., Benito-León, J. and Reuber, M. (2014). The influence of cognitive impairment on health-related quality of life in neurological disease. Acta Neuropsychiatrica, 22, 213. doi:10.1111/j.1601-5215.2009.00439.x.
Mograbi, D. C., Brown, R. G. and Morris, R. G. (2009). Anosognosia in Alzheimer's disease–the petrified self. Consciousness and Cognition, 18, 9891003. doi:10.1016/j.concog.2009.07.005.
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., and The PRISMA Group. (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Medicine, 6, e1000097. doi:10.1371/journal.pmed.1000097.
Mol, M. E., van Boxtel, M. P., Willems, D. and Jolles, J. (2006). Do subjective memory complaints predict cognitive dysfunction over time? A six-year follow-up of the Maastricht Aging Study. International Journal of Geriatric Psychiatry, 21, 432441. doi: 10.1002/gps.1487.
Mol, M. E., van Boxtel, M. P., Willems, D., Verhey, F. R. and Jolles, J. (2009). Subjective forgetfulness is associated with lower quality of life in middle-aged and young-old individuals: a 9-year follow-up in older participants from the Maastricht Aging Study. Aging & Mental Health, 13, 699705. doi:10.1080/13607860902845541.
Mol, M., Carpay, M., Ramakers, I., Rozendaal, N., Verhey, F. and Jolles, J. (2007). The effect of perceived forgetfulness on quality of life in older adults; a qualitative review. International Journal of Geriatric Psychiatry, 22, 393400. doi:10.1002/gps.1686.
Montejo, P., Montenegro, M., Fernandez, M. A. and Maestu, F. (2011). Subjective memory complaints in the elderly: prevalence and influence of temporal orientation, depression and quality of life in a population-based study in the city of Madrid. Aging & Mental Health, 15, 8596. doi:10.1080/13607863.2010.501062.
Montejo, P., Montenegro, M., Fernández, M. A. and Maestú, F. (2012). Memory complaints in the elderly: quality of life and daily living activities. A population based study. Archives of Gerontology and Geriatrics, 54, 298304. doi:10.1016/j.archger.2011.05.021.
Mount, B. and Cohen, S. (1995). Quality of life in the face of life-threatening illness: what should we be measuring?. Current Oncology, 2, 121125.
National Research Council. (2001). Preparing for an Aging World: The Case for Cross-National Research. Washington, DC: National Academies Press. doi:10.17226/10120.
Neugarten, B. L., Havighurst, R. J. and Tobin, S. S. (1961). The measurement of life satisfaction. Journal of Gerontology, 16, 134143.
Office of Disease Prevention and Health Promotion. (2010). Health-related quality of life and well-being. Healthy People, 2020, 16.
Ogata, S., Hayashi, C., Sugiura, K. and Hayakawa, K. (2015). Association between subjective memory complaints and impaired higher-level functional capacity in people aged 60 years or older. Archives of Gerontology and Geriatrics, 60, 201205. doi:
Pusswald, G. et al. (2015). Health-related quality of life in patients with subjective cognitive decline and mild cognitive impairment and its relation to activities of daily living. Journal of Alzheimer's Disease, 47, 479486. doi:10.3233/JAD-150284.
Rabin, L. A. et al. Subjective cognitive decline in older adults: an overview of self-report measures used across 19 international research studies. Journal of Alzheimer's Disease, 48 (Suppl. 1), S63–86 doi:10.3233/JAD-150154.
Requena, C., Lopez, V. and Ortiz, T. (2009). Satisfaction with life related to functionality in active elderly people. Actas Espanolas de Psiquiatria, 37, 6167.
Schmidt, S., Mühlan, H. and Power, M. (2006). The EUROHIS-QOL 8-item index: psychometric results of a cross-cultural field study. The European Journal of Public Health, 16, 420428. doi:10.1093/eurpub/cki155.
Scholtissen-In de Braek, D. M., Hurks, P. P., van Boxtel, M. P., Dijkstra, J. B. and Jolles, J. (2011). The identification of attention complaints in the general population and their effect on quality of life. Journal of Attention Disorders, 15, 4655. doi:10.1177/1087054709347260.
Schulz, R. and Heckhausen, J. (1996). A life span model of successful aging. American Psychologist, 51, 702714.
Seidel, J. A., Andrews, W. P., Owen, J., Miller, S. D. and Buccino, D. L. (2017). Preliminary validation of the rating of outcome scale and equivalence of ultra-brief measures of well-being. Psychological Assessment, 29, 65. doi: 10.1037/pas0000311.
Sims, R. C., Whitfield, K. E., Ayotte, B. J., Gamaldo, A. A., Edwards, C. L. and Allaire, J. C. (2011). Subjective memory in older African Americans. Experimental Aging Research, 37, 220240. doi:10.1080/0361073X.2011.555640.
Sohrabi, H. R. et al. (2009). The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein Eepsilon4 carriers and non-carriers. Journal of Alzheimer's Disease, 17, 6979. doi:10.3233/JAD-2009-1018.
Steinberg, S. I. et al. (2013). Subjective memory complaints, cognitive performance, and psychological factors in healthy older adults. American Journal of Alzheimer's Disease And Other Dementias, 28, 776783. doi:10.1177/1533317513504817.
Steptoe, A., Deaton, A. and Stone, A. (2015). Subjective wellbeing, health, and ageing. The Lancet, 385, 640648. doi: 10.1016/S0140-6736(13)61489-0.
Trouton, A., Stewart, R. and Prince, M. (2006). Does social activity influence the accuracy of subjective memory deficit? Findings from a British community survey. Journal of the American Geriatrics Society, 54, 11081113. doi:10.1111/j.1532-5415.2006.00800.x.
van Boxtel, M. P. J., Ponds, R. W. H. M. and Jolles, J. (2000). Age-related changes in subjective cognitive functioning. Educational Gerontology, 26, 2626.
Verhaeghen, P., Geraerts, N. and Marcoen, A. (2000). Memory complaints, coping, and well-being in old age: a systemic approach. The Gerontologist, 40, 540548. doi:10.1093/geront/40.5.540.
Wahl, H.-W., Iwarsson, S. and Oswald, F. (2012). Aging well and the environment: toward an integrative model and a research agenda for the future. The Gerontologist, 52, 306313. doi: 10.1093/geront/gnr154.
Ware, J. E. and Sherbourne, C. D. (1992). The MOS 36-item shortform health survey (SF-36). I. Conceptual framework and item selection. Medical Care, 30, 473483.
Wilson, I. B. and Cleary, P. D. (1995). Linking clinical variables with health-related quality of life: a conceptual model of patient outcomes. JAMA, 273, 5965. doi:10.1001/jama.1995.03520250075037.
Woods, S. P., Weinborn, M., Li, Y. R., Hodgson, E., Ng, A. R. and Bucks, R. S. (2015). Does prospective memory influence quality of life in community-dwelling older adults?. Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition, 22, 679692. doi:10.1080/13825585.2015.1027651.
The WHOQOL Group. (1998). The World Health Organization Quality of Life Assessment (WHOQOL): development and general psychometric properties. Social Science and Medicine, 46, 15691585.
Zajacova, A. and Burgard, S. A. (2013). Healthier, wealthier, and wiser: a demonstration of compositional changes in aging cohorts due to selective mortality. Population Research and Policy Review, 32, 311324. doi:10.1007/s11113-013-9273-x.
Zhan, L. (1992). Quality of life: conceptual and measurement issues. Journal of Advanced Nursing, 17, 795800.


Subjective cognitive impairment and quality of life: a systematic review

  • Nikki L. Hill (a1), Caroline McDermott (a1), Jacqueline Mogle (a1), Elizabeth Munoz (a2), Nicole DePasquale (a3), Rachel Wion (a1) and Emily Whitaker (a1)...


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