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Fluid dynamics in intracranial aneurysms treated with flow-diverting stents: effect of multiple geometrical parameters

Published online by Cambridge University Press:  23 October 2023

Fanette Chassagne Open the ORCID record for Fanette Chassagne [Opens in a new window] ,
Michael C. Barbour Open the ORCID record for Michael C. Barbour [Opens in a new window] ,
Michael R. Levitt Open the ORCID record for Michael R. Levitt [Opens in a new window]  and
Alberto Aliseda Open the ORCID record for Alberto Aliseda [Opens in a new window]
Fanette Chassagne*
Affiliation:
SAINBIOSE INSERM U1059, Mines Saint-Étienne, F-42023 Saint-Étienne, France
Michael C. Barbour
Affiliation:
Department of Mechanical Engineering, University of Washington, Seattle, WA 98105, USA
Michael R. Levitt
Affiliation:
Department of Mechanical Engineering, University of Washington, Seattle, WA 98105, USA Department of Neurological Surgery, University of Washington, Seattle, WA 98107, USA Department of Radiology, University of Washington, Seattle, WA 98107, USA
Alberto Aliseda
Affiliation:
Department of Mechanical Engineering, University of Washington, Seattle, WA 98105, USA Department of Neurological Surgery, University of Washington, Seattle, WA 98107, USA
*
†Email address for correspondence: fanette.chassagne@emse.fr
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Abstract

Characterizing the haemodynamics in intracranial aneurysms is of high interest as it impacts aneurysm growth, rupture and treatment, especially with flow-diverting stents (FDS). Flow in these geometries is known to depend on the Dean, Reynolds and Womersley numbers, $De$, $Re$, $Wo$, but is also influenced by geometrical parameters such as the sac shape or the size of the opening. Via particle image velocimetry, this parametric study aimed at evaluating the combined effects of $Re$, $De$, $Wo$ and the geometry of the aneurysmal sac on the haemodynamics before and after treatment with FDS. Eight ellipsoidal idealized aneurysm models were created with two curvatures of the parent vessel, two aspect ratios of the sac and two neck sizes. Before treatment, a single counter-rotating vortex, whose strength increases with $Re$ and $De$, as well as with the neck size and the aspect ratio, was observed in the sac for all but one geometry. After treatment with FDS, four different flow topologies were observed, depending on the geometry: no separation, separation for part of the cycle, two opposing vortices or a single counter-rotating vortex. A linear model with interaction revealed the predominant effect of $De$ and the curvature of the parent vessel on the haemodynamics before and after treatment. This work once more demonstrated the primary role of haemodynamics in the treatment of intracranial aneurysms with FDS. Future work will consider the complexity of patient-specific geometries, and their effects on both the haemodynamics in the sac and the porosity of the FDS.

JFM classification

Biological Fluid Dynamics: Blood flow Biological Fluid Dynamics: Biomedical flows
Type
JFM Papers
Information
Journal of Fluid Mechanics , Volume 973 , 25 October 2023 , A45
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© The Author(s), 2023. Published by Cambridge University Press

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Chassagne et al. Supplementary Movie

Illustration of the vortex breakdown for the extreme geometry K+/AR+/N+

Download Chassagne et al. Supplementary Movie(Video)
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