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Haemodynamic stresses and the onset and progression of vasculardiseases

Published online by Cambridge University Press:  29 November 2010

JUAN C. LASHERAS
JUAN C. LASHERAS*
Affiliation:
Departments of Mechanical and Aerospace Engineering and Bioengineering, University of California San Diego, La Jolla, CA 92093-0411, USA
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Abstract

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Abdominal aortic aneurysm (AAA), a common vascular disease among the adultpopulation, forms in the portion of the aorta below the renal arteries andupstream of its bifurcation into the two iliac arteries. While the precise causeof this vascular disease is still unknown, it is believed to be multi-factorialand predominantly degenerative, arising through a complex interplay amongseveral biological factors as well as from specific local changes in thehaemodynamic stresses on the vessel's wall. Using a simple mechanical model tosimulate the difference in the stiffness of the aorta and iliac arteries,Duclaux, Gallaire & Clanet (J. Fluid Mech., 2010, thisissue, vol. 664, pp. 5–32) propose a scaling argument for thetransition between homogeneous and inhomogeneous deformation of an elastictubular membrane that offers a plausible explanation for the observedlocalization of the AAAs. While neglecting long-term tissue remodelling andother important biological processes, the fluid mechanics model of Duclauxet al. (2010) appears to be consistent with some knownassociated risk factors.

JFM classification

Biological Fluid Dynamics: Biomedical flows Biological Fluid Dynamics: Blood flow

Information

Type
Focus on Fluids
Information
Journal of Fluid Mechanics , Volume 664 , 10 December 2010 , pp. 1 - 4
Copyright
Copyright © Cambridge University Press 2010

References

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