Large-scale circulation (LSC) dynamics have been studied in thermal convection driven by heat-releasing particles via the four-way coupled Euler–Lagrange approach. We consider a wide range of Rayleigh–Robert number (${\textit{Rr}}=4.97\times 10^{5} - 4.97 \times 10^{8}$) and density ratio ($\hat {\rho }_r=1- 1000$) that characterize the thermal buoyancy and the particle inertia, respectively. An intriguing flow transition has been found as $\hat {\rho }_r$ continuously increases, involving in sequence three typical LSC regimes, i.e. the bulk-flow-up regime, the marginal regime and the bulk-flow-down (BFD) regime. The comprehensive influence of the LSC regime transition is demonstrated by examining the key flow statistics. As integral flow responses, the heat transfer efficiency and flow intensity change substantially when the LSC regime transition happens, and the thermal boundary layer thicknesses at the top and bottom walls exhibit similar alterations. Significant local accumulation of particles occurs as $\hat {\rho }_r$ increases to a sufficiently high value, resulting in a great modification in the flow dynamics. Specifically, particles aggregate near the sidewalls and heat the local surrounding fluid to generate rising warmer plumes that drive the LSC regime transition. Of interest, well-patterned cellular structures of particles take place near the top wall and obtain notable deviation from the thermal convection cells for the BFD regimes. A mechanical interpretation is proposed and substantiated based on a conceptual vortex–particle model, namely, the centrifugal motion of heat-releasing particles that is confirmed to play a driving role for the LSC regime transition.