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Biocompatibility and anticancer activity of L-phenyl alanine-coated iron oxide magnetic nanoparticles as potential chrysin delivery system

  • Hamed Nosrati (a1), Elham Javani (a2), Marziyeh Salehiabar (a2), Hamidreza Kheiri Manjili (a3), Soodabeh Davaran (a4) and Hossein Danafar (a5)...

In this project, we described the production of chrysin-loaded L-phenyl alanine (Phe)-coated iron oxide magnetic nanoparticles (chrysin@Phe@IOMNs). chrysin@Phe@IOMNs were characterized by X-ray diffraction, thermogravimetric analysis, fourier transform infrared spectroscopy, vibrating sample magnetometer, and transmission electron microscopy techniques. Next, hemocompatibility and biocompatibility of Phe-coated IOMNs were determined by hemolysis and MTT assays on HFF-2 and HEK-293 cell lines, respectively. Finally, the anticancer activity of chrysin@Phe@IOMNs was examined on MCF-7 cell line. The outcomes direct that as-prepared nanocarriers are nontoxic and biocompatible and also chrysin@Phe@IOMNs are appropriate for chrysin delivery and other hydrophobic therapeutic agents.

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Journal of Materials Research
  • ISSN: 0884-2914
  • EISSN: 2044-5326
  • URL: /core/journals/journal-of-materials-research
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