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Designing porous silicon-based microparticles as carriers for controlled delivery of mitoxantrone dihydrochloride

  • Adi Tzur-Balter (a1), Anna Rubinski (a2) and Ester Segal (a3)
Abstract
Abstract

Porous silicon (PSi) microparticles are designed as tunable delivery carriers for the model anticancer drug, mitoxantrone dihydrochloride (MTX). The surface of the native nanostructured PSi particles was chemically modified by grafting dodecyl and undecanoic acid via thermal hydrosilylation with 1-dodecene and undecylenic acid, respectively. Attenuated total reflectance Fourier transform infrared spectroscopy and nitrogen adsorption–desorption measurements were used to characterize the physiochemical properties of the native and chemically modified PSi microparticles. MTX was loaded by physical adsorption to the native and dodecyl-terminated PSi or by covalent attachment to the undecanoic acid-terminated microparticles. Both drug release profile and the Si erosion of the carriers were significantly affected by the surface chemistry of the PSi microparticles and the drug loading method. The MTX release spans over a period of several hours to weeks, as dictated by these parameters. In vitro cytotoxicity studies on human breast carcinoma (MDA-MB-231) cells revealed that the released MTX maintains its cytotoxic functionality, in comparison to the very low toxicity of all PSi microparticles.

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b)Address all correspondence to this author. e-mail: esegal@tx.technion.ac.il
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L.M. Bonanno and E. Segal : Nanostructured porous silicon-polymer-based hybrids: From biosensing to drug delivery. Nanomedicine 6(10), 1755 (2011).

L.M. Bimbo , M. Sarparanta , H.A. Santos , A.J. Airaksinen , E. Makila , T. Laaksonen , L. Peltonen , V.P. Lehto , J. Hirvonen , and J. Salonen : Biocompatibility of thermally hydrocarbonized porous silicon nanoparticles and their biodistribution in rats. ACS Nano 4(6), 3023 (2010).

J. Salonen , A.M. Kaukonen , J. Hirvonen , and V.P. Lehto : Mesoporous silicon in drug delivery applications. J. Pharm. Sci. 97(2), 632 (2008).

P. Kinnari , E. Makila , T. Heikkila , J. Salonen , J. Hirvonen , and H.A. Santos : Comparison of mesoporous silicon and non-ordered mesoporous silica materials as drug carriers for itraconazole. Int. J. Pharm. 414(1–2), 148 (2011).

X. Li , J.S. John , J.L. Coffer , Y. Chen , R.F. Pinizzotto , J. Newey , C. Reeves , and L.T. Canham : Porosified silicon wafer structures impregnated with platinum anti-tumor compounds: Fabrication, characterization, and diffusion studies. Biomed. Microdevices 2, 265 (2000).

J.H. Park , L. Gu , G. von Maltzahn , E. Ruoslahti , S.N. Bhatia , and M.J. Sailor : Biodegradable luminescent porous silicon nanoparticles for in vivo applications. Nat. Mater. 8(4), 331 (2009).

L.A. Perelman , C. Pacholski , Y.Y. Li , M.S. VanNieuwenhze , and M.J. Sailor : pH-triggered release of vancomycin from protein-capped porous silicon films. Nanomedicine (Lond) 3(1), 31 (2008).

J. Salonen , L. Laitinen , A.M. Kaukonen , J. Tuura , M. Bjorkqvist , T. Heikkila , K. Vaha-Heikkila , J. Hirvonen and V.P. Lehto : Mesoporous silicon microparticles for oral drug delivery: Loading and release of five model drugs. J. Controlled Release 108(2–3), 362 (2005).

H.A. Santos , J. Salonen , L.M. Bimbo , V.P. Lehto , L. Peltonen , and J. Hirvonen : Mesoporous materials as controlled drug delivery formulations. J. Drug Delivery Sci. Technol. 21(2), 139 (2011).

L.T. Canham : Bioactive silicon structure fabrication through nanoetching techniques. Adv. Mater. 7(12), 1033 (1995).

J.P.S. McInnes and N.H. Voelcker : Silicon-polymer hybrid materials for drug delivery. Future Med. Chem. 1, 1051 (2009).

N. Artzi , N. Oliva , C. Puron , S. Shitreet , S. Artzi , A. Bon Ramos , A. Groothuis , G. Sahagian , and E.R. Edelman : In vivo and in vitro tracking of erosion in biodegradable materials using non-invasive fluorescence imaging. Nat. Mater. 10, 704 (2011).

L.T. Canham , M.P. Stewart , J.M. Buriak , C.L. Reeves , M. Anderson , E.K. Squire , P. Allcock , and P.A. Snow : Derivatized porous silicon mirrors: Implantable optical components with slow resorbability. Phys. Status Solidi A 182(1), 521 (2000).

E.J. Anglin , L.Y. Cheng , W.R. Freeman , and M.J. Sailor : Porous silicon in drug delivery devices and materials. Adv. Drug Delivery Rev. 60(11), 1266 (2008).

J.C. Doughty , E. Kane , T.G. Cooke , and C.S. McArdle : Mitoxantrone and methotrexate chemotherapy with and without mitomycin C in the regional treatment of locally advanced breast cancer. Breast 11(1), 97 (2002).

F. Hagemeister , F. Cabanillas , M. Coleman , S.A. Gregory , and P.L. Zinzani : The role of mitoxantrone in the treatment of indolent lymphomas. The Oncologist 10(2), 150 (2005).

S. Brunauer , P.H. Emmett , and E. Teller : Adsorption of gases in multimolecular layers. J. Am. Chem. Soc. 60(309), (1938).

E. Segal , L.A. Perelman , F. Cunin , F. Di Renzo , J.M. Devoisselle , Y.Y. Li , and M.J. Sailor : Confinement of thermoresponsive hydrogels in nanostructured porous silicon dioxide templates. Adv. Funct. Mater. 17(7), 1153 (2007).

H.A. Santos , J. Riikonen , J. Salonen , E. Makila , T. Heikkila , T. Laaksonen , L. Peltonen , V.P. Lehto , and J. Hirvonen : In vitro cytotoxicity of porous silicon microparticles: Effect of the particle concentration, surface chemistry and size. Acta Biomater. 6(7), 2721 (2010).

J. Salonen and V.P. Lehto : Fabrication and chemical surface modification of mesoporous silicon for biomedical applications. Chem. Eng. J. 137, 162 (2008).

L.M. Bimbo , E. Mäkiläb , T. Laaksonen , V-P. Lehto , J. Salonen , J. Hirvonen , and H.A. Santos : Drug permeation across intestinal epithelial cells using porous silicon nanoparticles. Biomaterials 32(10), 2625 (2011).

C. Chiappini , E. Tasciotti , J.R. Fakhoury , D. Fine , L. Pullan , Y-C. Wang , L. Fu , X. Liu , and M. Ferrari : Tailored porous silicon microparticles: Fabrication and properties. ChemPhysChem 11(5), 1029 (2010).

S.D. Alvarez , A.M. Derfus , M.P. Schwartz , S.N. Bhatia , and M.J. Sailor : The compatibility of hepatocytes with chemically modified porous silicon with reference to in vitro biosensors. Biomaterials 30(1), 26 (2009).

M.P. Schwartz , F. Cunin , R.W. Cheung , and M.J. Sailor : Chemical modification of silicon surfaces for biological applications. Phys. Status Solidi A 202(8), 1380 (2005).

K.L. Jarvis , T.J. Barnes , A. Badalyan , P. Pendleton , and C.A. Prestidge : Impact of thermal oxidation on the adsorptive properties and structure of porous silicon particles. J. Phys. Chem. C, 112, 9717 (2008).

E.J. Anglin , M.P. Schwartz , V.P. Ng , L.A. Perelman , and M.J. Sailor : Engineering the chemistry and nanostructure of porous silicon Fabry-Pérot films for loading and release of a steroid. Langmuir 20(25), 11264 (2004).

E.C. Wu , J.H. Park , J. Park , E. Segal , F. Cunin , and M.J. Sailor : Oxidation-triggered release of fluorescent molecules or drugs from mesoporous Si microparticles. ACS Nano 2(11), 2401 (2008).

M. Kovalainen , J. Mönkäre , E. Mäkilä , J. Salonen , V.P. Lehto , K.H. Herzig , and H. Järvinen : Mesoporous silicon (PSi) for sustained peptide delivery: Effect of PSi microparticle surface chemistry on peptide YY3-36 release. Pharm. Res. 29, 837 (2012).

E.C. Wu , J.S. Andrew , L.Y. Cheng , W.R. Freeman , L. Pearson , and M.J. Sailor : Real-time monitoring of sustained drug release using the optical properties of porous silicon photonic crystal particles. Biomaterials 32(7), 1957 (2011).

K.A. Kilian , T. Booking , K. Gaus , M. Gal , and J.J. Gooding : Si-C linked oligo(ethylene glycol) layers in silicon-based photonic crystals: Optimization for implantable optical materials. Biomaterials 28(20), 3055 (2007).

L. Cheng , E. Anglin , F. Cunin , D. Kim , M.J. Sailor , I. Falkenstein , A. Tammewar , and W.R. Freeman : Intravitreal properties of porous silicon photonic crystals: A potential self-reporting intraocular drug-delivery vehicle. Br. J. Ophthalmol. 92(5), 705 (2008).

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Journal of Materials Research
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