Hostname: page-component-76fb5796d-25wd4 Total loading time: 0 Render date: 2024-04-25T08:21:09.189Z Has data issue: false hasContentIssue false
  • English
  • Français

Synthesis and characterization of thermosensitive hydrogel with improved mechanical properties

Published online by Cambridge University Press:  13 August 2015

Hengjun Gai ,
Jie Wu ,
Chenyu Wu ,
Xuejiao Sun ,
Fengjun Jia  and
Yueqin Yu
Hengjun Gai
Affiliation:
State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China
Jie Wu
Affiliation:
State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China
Chenyu Wu
Affiliation:
College of Materials Science and Engineering, Chongqing University, Chongqing 400044, People's Republic of China
Xuejiao Sun
Affiliation:
State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China
Fengjun Jia
Affiliation:
State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China
Yueqin Yu*
Affiliation:
State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China
*
a)Address all correspondence to this author. e-mail: qustyu@163.com
Get access

Abstract

Semi-interpenetrating polymer network (semi-IPN) and fully interpenetrating polymer network (full-IPN) hydrogels composed of sodium alginate (SA) and N-isopropylacrylamide (NIPAAm) were prepared with Ca2+ and N,N′-methylenebisacrylamide (BIS) as the cross-linkers, respectively. The influence of the SA content and crosslinking degree of alginate on thermosensitive, swelling, mechanical, morphological, and thermal properties was investigated in detail. The hydrogels obtained exhibited obvious thermosensitivity and rapid swelling rate. The presence of Ca2+ contributed to the improvement of mechanical properties obviously, without altering the thermosensitivity and network porosity of the hydrogels significantly. The compressive strength of full-IPN hydrogel was improved considerably, while the tensile strength was increased by 308.5% than semi-IPN hydrogel. The Tg of full-IPN dried hydrogel ran up to 142.9 °C with respect to 97.3 °C of pure PNIPAAm, and the improvement indicated that hydrogel with more compact structure was prepared.

Keywords

interpenetrating polymer network (IPN)thermoresponsive hydrogelN-isopropylacrylamidesodium alginatemechanical property
Type
Articles
Information
Journal of Materials Research , Volume 30 , Issue 16 , 28 August 2015 , pp. 2400 - 2407
Copyright
Copyright © Materials Research Society 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Dumitriu, R.P., Mitchell, G.R., and Vasile, C.: Multi-responsive hydrogels based on N-isopropylacrylamide and sodium alginate. Polym. Int. 60(2), 222–233 (2011).Google Scholar
Kabiri, K., Zohuriaan-Mehr, M.J., Mirzadeh, H., and Kheirabadi, M.: Solvent-, ion- and pH- specific swelling of poly(2-acrylamido-2-methylpropane sulfonic acid) superabsorbing gels. J. Polym. Res. 17, 203–212 (2010).Google Scholar
Ju, H.K., Kim, S.Y., Kim, S.J., and Lee, Y.M.: pH/temperature-responsive semi-IPN hydrogels composed of alginate and poly(N-isopropylacrylamide). J. Appl. Polym. Sci. 83(5), 1128–1139 (2002).CrossRefGoogle Scholar
Li, D.X., Cui, Y., Wang, K.W., He, Q., Yan, X.H., and Li, J.B.: Thermosensitive nanostructures comprising gold nanoparticles grafted with block copolymers. Adv. Funct. Mater. 17, 3134–3140 (2007).Google Scholar
Li, D.X., He, Q., Cui, Y., Wang, K.W., Zhang, X.M., and Li, J.B.: Thermosensitive copolymer networks modify gold nanoparticles for nanocomposite entrapment. Chem. Eur. J. 13, 2224–2229 (2007).Google Scholar
Zhao, S.P., Zhou, F., and Li, L.Y.: pH-and temperature-responsive behaviors of hydrogels resulting from the photopolymerization of allylated chitosan and N-isopropylacrylamide, and their drug release profiles. J. Polym. Res. 19(9), 9944 (2012).Google Scholar
Shi, J., Alves, N.M., and Mano, J.F.: Drug release of pH/temperature-responsive calcium alginate/poly(N-isopropylacrylamide) semi-IPN beads. Macromol. Biosci. 6, 358–363 (2006).Google Scholar
Asmarandei, I., Fundueanu, G., Cristea, M., Harabagiu, V., and Constantin, M.: Thermo- and pH-sensitive interpenetrating poly(N-isopropylacrylamide)/carboxy-methyl pullulan network for drug delivery. J. Polym. Res. 20, 293–306 (2013).Google Scholar
Cho, E.C., Lee, J., and Cho, K.: Role of bound water and hydrophobic interaction in phase transition of poly(N-isopropylacrylamide) aqueous solution. Macromolecules 36, 9929–9934 (2003).Google Scholar
Yu, Y.Q., Li, Z.Z., Tian, H.J., Zhang, S.S., and Ouyang, P.K.: Synthesis and characterization of thermoresponsive hydrogels cross-linked with acryloyloxyethylaminopolysuccinimide. Colloid Polym. Sci. 285, 1553–1560 (2007).Google Scholar
Yu, Y.Q., Xu, Y., Ning, H.S., and Zhang, S.S.: Swelling behaviors of thermoresponsive hydrogels cross-linked with acryloyloxyethylaminopolysuccinimide. Colloid Polym. Sci. 286, 1165–1171 (2008).Google Scholar
Yu, Y.Q., Li, Y.S., Liu, L.X., Zhu, C.J., and Xu, Y.: Synthesis and characterization of pH-and thermoresponsive poly(N-isopropylacrylamide-co-itaconic acid) hydrogels crosslinked with N-maleyl chitosan. J. Polym. Res. 18, 283–291 (2011).Google Scholar
Saha, S., Pal, A., Kundu, S., Basu, S., and Pal, T.: Photochemical green synthesis of calcium-alginate-stabilized Ag and Au nanoparticles and their catalytic application to 4-nitrophenol reduction. Langmuir 26(4), 2885–2893 (2010).Google Scholar
Nunamaker, E.A., Purcell, E.K., and Kipke, D.R.: In vivo stability and biocompatibility of implanted calcium alginate disks. J. Biomed. Mater. Res., Part A 83A(4), 1128–1137 (2007).Google Scholar
Hernandez, R. and Mijangos, C.: In situ synthesis of magnetic iron oxide nanoparticles in thermally responsive alginate-poly(N-isopropylacrylamide) semi-interpenetrating polymer networks. Macromol. Rapid Commun. 30(3), 176–181 (2009).Google Scholar
Zhang, G.Q., Zha, L.S., Zhou, M.H., Ma, J.H., and Liang, B.R.: Rapid deswelling of sodium alginate/poly(N-isopropylacrylamide) semi-interpenetrating polymer network hydrogels in response to temperature and pH changes. Colloid Polym. Sci. 283(4), 431–438 (2005).CrossRefGoogle Scholar
Lee, S.B., Park, E.K., Lim, Y.M., Cho, S.K., Kim, S.Y., Lee, Y.M., and Nho, Y.C.: Preparation of alginate/poly(N-isopropylacrylamide) semi-interpenetrating and fully interpenetrating polymer network hydrogels with γ-ray irradiation and their swelling behaviors. J. Appl. Polym. Sci. 100(6), 4439–4446 (2006).CrossRefGoogle Scholar
De Moura, M.R., Aouada, F.A., Favaro, S.L., Radovanovic, E., Rubira, A.F., and Muniz, E.C.: Release of BSA from porous matrices constituted of alginate- Ca2+ and PNIPAAm-interpenetrated networks. Mater. Sci. Eng., C 29(8), 2319–2325 (2009).Google Scholar
Piai, J.F., de Moura, M.R., Rubira, A.F., and Muniz, E.C.: Kinetic study of bovine serum albumin (BSA) released from alginate-Ca2+/PNIPAAm hydrogels. Macromol. Symp. 266(1), 108–113 (2008).Google Scholar