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Autobiographical Memory Fluency Reductions in Cognitively Unimpaired Middle-Aged and Older Adults at Increased Risk for Alzheimer’s Disease Dementia

Published online by Cambridge University Press:  29 January 2021

Matthew D. Grilli Open the ORCID record for Matthew D. Grilli [Opens in a new window] ,
Aubrey A. Wank ,
Matthew J. Huentelman  and
Lee Ryan
Matthew D. Grilli*
Affiliation:
Psychology Department, University of Arizona, Tucson, AZ, USA Neurology Department, University of Arizona, Tucson, AZ, USA Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA
Aubrey A. Wank
Affiliation:
Psychology Department, University of Arizona, Tucson, AZ, USA
Matthew J. Huentelman
Affiliation:
The Translational Genomics Research Institute, Phoenix, AZ, USA Arizona Alzheimer’s Consortium, Phoenix, AZ, USA
Lee Ryan
Affiliation:
Psychology Department, University of Arizona, Tucson, AZ, USA Neurology Department, University of Arizona, Tucson, AZ, USA Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA
*
*Correspondence and reprint requests to: Matthew D. Grilli, Psychology Department, University of Arizona, 1503 E. University Blvd, PO Box 210068, Tucson, AZ85721, USA. E-mail: mdgrilli@arizona.edu
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Abstract

Objective:

Recent research has revealed that cognitively unimpaired older adults who are at higher risk for developing Alzheimer’s disease (AD) dementia often exhibit subtle cognitive alterations in their neuropsychological profiles. Emerging evidence suggests that autobiographical memory, which is memory for personal events and knowledge, may be sensitive to early AD-related cognitive alterations. In the present study, we investigated whether the rapid generation of autobiographical memory category exemplars, a retrieval process that taxes the neural network that is vulnerable to early AD, is compromised in cognitively unimpaired middle-aged and older carriers of the e4 allele of the apolipoprotein E gene (APOE4), which increases risk for AD dementia.

Methods:

In addition to standard neuropsychological tests, we administered a fluency task that requires generating exemplars for two types of autobiographical memory, namely episodic memories and personal semantics, to a group of cognitively unimpaired middle-aged and older adults (n = 45) enriched with APOE4 carriers (n = 20).

Results:

While no APOE4 deficits were found on standard neuropsychological tests, episodic and personal semantic exemplar generation was reduced in the APOE4 group.

Discussion:

Autobiographical memory aberrations associated with a higher risk for AD are evident in fluency and affect both episodic memory and personal semantics.

Keywords

Autobiographical memoryApolipoprotein EAlzheimer’s diseaseCognitive agingMedial temporal lobeEpisodic memorySemantic memory
Type
Regular Research
Information
Journal of the International Neuropsychological Society , Volume 27 , Issue 9 , October 2021 , pp. 905 - 915
Copyright
Copyright © INS. Published by Cambridge University Press, 2021

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