Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 14
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Esfahani-Bayerl, Nazli Finke, Carsten Braun, Mischa Düzel, Emrah Heekeren, Hauke R. Holtkamp, Martin Hasper, Dietrich Storm, Christian and Ploner, Christoph J. 2016. Visuo-spatial memory deficits following medial temporal lobe damage: A comparison of three patient groups. Neuropsychologia, Vol. 81, p. 168.

    Li, Liya Deng, Bin Wang, Shiquan Zhong, Haixing Liu, Zhaoyu Jin, Weilin Jiang, Tao Xiao, Zhaoyang and Wang, Qiang 2016. Asynchronous therapy targeting Nogo-A enhances neurobehavioral recovery by reducing neuronal loss and promoting neurite outgrowth after cerebral ischemia in mice. Journal of Drug Targeting, Vol. 24, Issue. 1, p. 13.

    Ørbo, Marte Aslaksen, Per M. Larsby, Kristina Schäfer, Christoph Tande, Pål M. and Anke, Audny 2016. Alterations in cognitive outcome between 3 and 12 months in survivors of out-of-hospital cardiac arrest. Resuscitation, Vol. 105, p. 92.

    Perez, Claudia A. Samudra, Niyatee and Aiyagari, Venkatesh 2016. Cognitive and Functional Consequence of Cardiac Arrest. Current Neurology and Neuroscience Reports, Vol. 16, Issue. 8,

    Lilja, G. Nilsson, G. Nielsen, N. Friberg, H. Hassager, C. Koopmans, M. Kuiper, M. Martini, A. Mellinghoff, J. Pelosi, P. Wanscher, M. Wise, M.P. Östman, I. and Cronberg, T. 2015. Anxiety and depression among out-of-hospital cardiac arrest survivors. Resuscitation, Vol. 97, p. 68.

    Fugate, Jennifer E. and Rabinstein, Alejandro A. 2014. Life after cardiac arrest: Better with time. Resuscitation, Vol. 85, Issue. 2, p. 157.

    Greer, David M. Rosenthal, Eric S. and Wu, Ona 2014. Neuroprognostication of hypoxic–ischaemic coma in the therapeutic hypothermia era. Nature Reviews Neurology, Vol. 10, Issue. 4, p. 190.

    Iannacone, Stephen Leary, Marion Esposito, Emily C. Ruparel, Kosha Savitt, Adam Mott, Allison Richard, Jan A. Gur, Ruben C. and Abella, Benjamin S. 2014. Feasibility of Cognitive Functional Assessment in Cardiac Arrest Survivors Using an Abbreviated Laptop-Based Neurocognitive Battery. Therapeutic Hypothermia and Temperature Management, Vol. 4, Issue. 3, p. 131.

    Lin, Hung Wen Gresia, Victoria L Stradecki, Holly M Alekseyenko, Aleksey Dezfulian, Cameron Neumann, Jake T Dave, Kunjan R and Perez-Pinzon, Miguel A 2014. Protein kinase C delta modulates endothelial nitric oxide synthase after cardiac arrest. Journal of Cerebral Blood Flow & Metabolism, Vol. 34, Issue. 4, p. 613.

    Ørbo, Marte Aslaksen, Per M. Larsby, Kristina Norli, Lena Schäfer, Christoph Tande, Pål M. Vangberg, Torgil R. and Anke, Audny 2014. Determinants of cognitive outcome in survivors of out-of-hospital cardiac arrest. Resuscitation, Vol. 85, Issue. 11, p. 1462.

    Herzog, Eyal Tamis, Jacqueline Aziz, Emad F. and Shapiro, Janet M. 2013. A Novel Program Focused on Women Survivors Who Were Enrolled in a Cardiac Arrest Pathway. Critical Pathways in Cardiology, Vol. 12, Issue. 1, p. 28.

    Lilja, Gisela Nielsen, Niklas Friberg, Hans Horn, Janneke Kjaergaard, Jesper Pellis, Tommaso Rundgren, Malin Wetterslev, Jørn Wise, Matt P Nilsson, Fredrik and Cronberg, Tobias 2013. Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial. BMC Cardiovascular Disorders, Vol. 13, Issue. 1,

    Plesnila, Nikolaus 2013. Pathophysiological Role of Global Cerebral Ischemia following Subarachnoid Hemorrhage: The Current Experimental Evidence. Stroke Research and Treatment, Vol. 2013, p. 1.

    Wilder Schaaf, Kathryn P. Artman, Laura K. Peberdy, Mary Ann Walker, William C. Ornato, Joseph P. Gossip, Michelle R. and Kreutzer, Jeffrey S. 2013. Anxiety, depression, and PTSD following cardiac arrest: A systematic review of the literature. Resuscitation, Vol. 84, Issue. 7, p. 873.

  • Journal of the International Neuropsychological Society, Volume 17, Issue 2
  • January 2011, pp. 364-368

Cognitive and Functional Outcome After Out of Hospital Cardiac Arrest

  • Michael P. Alexander (a1) (a2), Ginette Lafleche (a3), David Schnyer (a4), Chun Lim (a1) and Mieke Verfaellie (a3)
  • DOI:
  • Published online: 04 January 2011

The nature of residual cognitive deficits after out of hospital cardiac arrest (OHCA) is incompletely described and has never been defined against a cardiac control (CC) group. The objective of this study is to examine neuropsychological outcomes 3 months after OHCA in patients in a “middle range” of acute severity. Thirty prospective OHCA admissions with coma >1 day and responsive but confused at 1 week, and 30 non-OHCA coronary care admissions were administered standard tests in five cognitive domains. OHCA subjects fell into two deficit profiles. One group (N = 20) had mild memory deficits and borderline psychomotor deficits compared to the CC group; 40% had returned to work. The other group (N = 10) had severe impairments in all domains. Coma duration was associated with group. Neither group had a high prevalence of depression. For most patients within the “middle range” of acute severity of OHCA, cognitive and functional outcomes at 3 months were encouraging. (JINS, 2011, 17, 364–368)

Corresponding author
Correspondence and reprint requests to: Michael P. Alexander, MD, Cognitive Neurology Unit, KS 253, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215. E-mail:
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

C.M. Booth , R.H. Boone , G. Tomlinson , A.S. Detsky (2004). Is this patient dead, vegetative, or severely neurologically impaired? Assessing outcome for comatose survivors of cardiac arrest. Journal of the American Medical Association, 291, 870879.

D.J. Callans (2004). Out-of-hospital cardiac arrest – the solution is shocking. New England Journal of Medicine, 351, 632634.

M.P. Earnest , P.Y. Yarnell , S.L. Merrill , G.L. Knapp (1980). Long-term survival and neurologic status after resuscitation from out-of-hospital cardiac arrest. Neurology, 30, 12981302.

J.R. Graves , J. Herlitz , A. Bang , A. Axelsson , L. Ekstrom , M. Holmberg , S. Holmberg (1997). Survivors of out of hospital cardiac arrest: The prognosis, longevity and functional status. Resuscitation, 35, 117121.

D.E. Levy , J.J. Caronna , B.H. Singer , R.H. Lapinski , H. Frydman , F. Plum (1985). Predicting outcome from hypoxic-ischemic coma. Journal of the American Medical Association, 253, 14201426.

C. Lim , M.P. Alexander , G. LaFleche , D.M. Schnyer , M. Verfaellie (2004). The neurologic and cognitive sequelae of cardiac arrest. Neurology, 63, 17741778.

W.T. Longstreth , T.S. Inui , L.A. Cobb , M.K. Copass (1983). Neurologic recovery after out-of-hospital cardiac arrest. Annals of Internal Medicine, 98, 588592.

V.R. Moulaert , J.A. Verbunt , C.M. van Heugten , D.T. Wade (2009). Cognitive impairments in survivors of out-of-hospital cardiac arrest: A systematic review. Resuscitation, 80, 297305.

R.W. Neumar , J.P. Nolan , C. Adrie , M. Aibiki , R.A. Berg , B.W. Böttiger , T. Vanden Hoek (2008). Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication: A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation, 118, 24522483.

M. Pleskota , R. Hazukovaa , H. Striteckab , E. Cermakovac , R. Pudila (2009). Long-term prognosis after out-of-hospital cardiac arrest with/without ST elevation myocardial infarction. Resuscitation, 80, 795804.

M. Rewers , R.E. Tilgreen , M.E. Crawford , N.-C. Hjortsø (2000). One-year survival after out-of-hospital cardiac arrest in Copenhagen according to the ‘Utstein style’. Resuscitation, 47, 137146.

R.O. Roine , S. Kajaste , M. Kaste (1993). Neuropsychological sequelae of cardiac arrest. Journal of the American Medical Association, 269, 237242.

M. Tiainen , E. Poutiainen , T. Kovala , O. Takkunen , O. Häppölä , R.O. Roine (2007). Cognitive and neurophysiological outcome of cardiac arrest survivors treated with therapeutic hypothermia. Stroke, 38, 23032308.

A.P. van Alem , R. de Vos , B. Schmand , R.W. Koster (2004). Cognitive impairment in survivors of out-of-hospital cardiac arrest. American Heart Journal, 148, 416421.

E.F. Wijdicks , A. Hijdra , G.B. Young , C.L. Bassetti , S. Wiebe , Quality Standards Subcommittee of the American Academy of Neurology (2006). Practice parameter: Prediction of out-come in comatose survivors after cardio-pulmonary resuscitation (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 67, 203210.

A.P. Yonelinas , N.E. Kroll , J.R. Quamme , M.M. Lazzara , M.-J. Sauve , K.F. Widaman , R.T. Knight (2002). Effects of extensive temporal lobe damage or mild hypoxia on recollection and familiarity. Nature Neuroscience, 5, 12361241.

G.B. Young (2009). Neurologic prognosis after cardiac arrest. New England Journal of Medicine, 361, 605611.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of the International Neuropsychological Society
  • ISSN: 1355-6177
  • EISSN: 1469-7661
  • URL: /core/journals/journal-of-the-international-neuropsychological-society
Please enter your name
Please enter a valid email address
Who would you like to send this to? *