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Cognitive Phenotypes of Older Adults with Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment: The Czech Brain Aging Study

Published online by Cambridge University Press:  03 November 2020

Dylan J. Jester Open the ORCID record for Dylan J. Jester [Opens in a new window] ,
Ross Andel Open the ORCID record for Ross Andel [Opens in a new window] ,
Katerina Cechová Open the ORCID record for Katerina Cechová [Opens in a new window] ,
Jan Laczó ,
Ondrej Lerch ,
Hana Marková ,
Tomás Nikolai Open the ORCID record for Tomás Nikolai [Opens in a new window] ,
Martin Vyhnálek  and
Jakub Hort
Dylan J. Jester*
Affiliation:
School of Aging Studies, University of South Florida, Tampa, FL 33612, USA
Ross Andel
Affiliation:
School of Aging Studies, University of South Florida, Tampa, FL 33612, USA Department of Neurology, Memory Clinic, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, 150 06, Czech Republic International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, 656 91, Czech Republic
Katerina Cechová
Affiliation:
Department of Neurology, Memory Clinic, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, 150 06, Czech Republic International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, 656 91, Czech Republic
Jan Laczó
Affiliation:
Department of Neurology, Memory Clinic, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, 150 06, Czech Republic International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, 656 91, Czech Republic
Ondrej Lerch
Affiliation:
Department of Neurology, Memory Clinic, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, 150 06, Czech Republic International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, 656 91, Czech Republic
Hana Marková
Affiliation:
Department of Neurology, Memory Clinic, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, 150 06, Czech Republic International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, 656 91, Czech Republic
Tomás Nikolai
Affiliation:
Department of Neurology, Memory Clinic, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, 150 06, Czech Republic International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, 656 91, Czech Republic
Martin Vyhnálek
Affiliation:
Department of Neurology, Memory Clinic, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, 150 06, Czech Republic International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, 656 91, Czech Republic
Jakub Hort
Affiliation:
Department of Neurology, Memory Clinic, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, 150 06, Czech Republic International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, 656 91, Czech Republic
*
*Correspondence and reprint requests to: Dylan Jester, School of Aging Studies, University of South Florida, 13301 Bruce B. Downs Blvd., MHC 1318, Tampa, FL 33612, USA. E-mail: djjester@usf.edu
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Abstract

Objective:

To compare cognitive phenotypes of participants with subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI), estimate progression to MCI/dementia by phenotype and assess classification error with machine learning.

Method:

Dataset consisted of 163 participants with SCD and 282 participants with aMCI from the Czech Brain Aging Study. Cognitive assessment included the Uniform Data Set battery and additional tests to ascertain executive function, language, immediate and delayed memory, visuospatial skills, and processing speed. Latent profile analyses were used to develop cognitive profiles, and Cox proportional hazards models were used to estimate risk of progression. Random forest machine learning algorithms reported cognitive phenotype classification error.

Results:

Latent profile analysis identified three phenotypes for SCD, with one phenotype performing worse across all domains but not progressing more quickly to MCI/dementia after controlling for age, sex, and education. Three aMCI phenotypes were characterized by mild deficits, memory and language impairment (dysnomic aMCI), and severe multi-domain aMCI (i.e., deficits across all domains). A dose–response relationship between baseline level of impairment and subsequent risk of progression to dementia was evident for aMCI profiles after controlling for age, sex, and education. Machine learning more easily classified participants with aMCI in comparison to SCD (8% vs. 21% misclassified).

Conclusions:

Cognitive performance follows distinct patterns, especially within aMCI. The patterns map onto risk of progression to dementia.

Keywords

Subjective cognitive complaintsMild cognitive impairmentTransition to dementiaMachine learningNeuropsychological performanceProspective cohort study

Information

Type
Regular Research
Information
Journal of the International Neuropsychological Society , Volume 27 , Issue 4 , April 2021 , pp. 329 - 342
Copyright
Copyright © INS. Published by Cambridge University Press, 2020

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